7CFN
 
 | | Cryo-EM structure of the INT-777-bound GPBAR-Gs complex | | 分子名称: | (2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid, CHOLESTEROL, G-protein coupled bile acid receptor 1, ... | | 著者 | Yang, F, Mao, C, Guo, L, Lin, J, Ming, Q, Xiao, P, Wu, X, Shen, Q, Guo, S, Shen, D, Lu, R, Zhang, L, Huang, S, Ping, Y, Zhang, C, Ma, C, Zhang, K, Liang, X, Shen, Y, Nan, F, Yi, F, Luca, V, Zhou, J, Jiang, C, Sun, J, Xie, X, Yu, X, Zhang, Y. | | 登録日 | 2020-06-27 | | 公開日 | 2020-09-09 | | 最終更新日 | 2021-04-07 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of GPBAR activation and bile acid recognition.
Nature, 587, 2020
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6LYG
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8WWW
 | | Crystal structure of the adenylation domain of SyAstC | | 分子名称: | Carrier domain-containing protein, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Li, Z, Zhu, Z, Zhu, D, Shen, Y. | | 登録日 | 2023-10-27 | | 公開日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Functional Application of the Single-Module NRPS-like d-Alanyltransferase in Maytansinol Biosynthesis
Acs Catalysis, 14, 2024
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8W6D
 | | CryoEM structure of NaDC1 in apo state | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | 登録日 | 2023-08-28 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6N
 | | NaS1 with sulfate in IN/OUT state | | 分子名称: | SODIUM ION, SULFATE ION, Solute carrier family 13 member 1 | | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | 登録日 | 2023-08-29 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6O
 | | NaS1 in IN/IN state | | 分子名称: | CHOLESTEROL, SODIUM ION, Solute carrier family 13 member 1 | | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | 登録日 | 2023-08-29 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6G
 | | NaDC1 with inhibitor ACA | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-[[(~{E})-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | 登録日 | 2023-08-28 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6C
 | | CryoEM structure of NaDC1 with Citrate | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CHOLESTEROL HEMISUCCINATE, CITRIC ACID, ... | | 著者 | Chi, X, Chen, Y, Li, Y, Dai, L, Zhang, Y, Shen, Y, Chen, Y, Shi, T, Yang, H, Wang, Z, Yan, R. | | 登録日 | 2023-08-28 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6T
 | | NaS1 in IN/OUT state | | 分子名称: | Solute carrier family 13 member 1 | | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | 登録日 | 2023-08-29 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6H
 | | NaS1 with sulfate - IN/IN state | | 分子名称: | CHOLESTEROL, SODIUM ION, SULFATE ION, ... | | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | 登録日 | 2023-08-28 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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6KNM
 | | Apelin receptor in complex with single domain antibody | | 分子名称: | Apelin receptor,Rubredoxin,Apelin receptor, Single domain antibody JN241, ZINC ION | | 著者 | Ma, Y.B, Ding, Y, Song, X, Ma, X, Li, X, Zhang, N, Song, Y, Sun, Y, Shen, Y, Zhong, W, Hu, L.A, Ma, Y.L, Zhang, M.Y. | | 登録日 | 2019-08-06 | | 公開日 | 2020-01-29 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure-guided discovery of a single-domain antibody agonist against human apelin receptor.
Sci Adv, 6, 2020
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7VGF
 | | cryo-EM structure of AMP-PNP bound human ABCB7 | | 分子名称: | Iron-sulfur clusters transporter ABCB7, mitochondrial, MAGNESIUM ION, ... | | 著者 | Yan, Q, Yang, X, Shen, Y. | | 登録日 | 2021-09-16 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7.
J.Struct.Biol., 214, 2022
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4EJS
 | | Structure of yeast elongator subcomplex Elp456 | | 分子名称: | Elongator complex protein 4, Elongator complex protein 5, Elongator complex protein 6 | | 著者 | Lin, Z, Zhao, W, Long, J, Shen, Y. | | 登録日 | 2012-04-07 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.606 Å) | | 主引用文献 | Crystal structure of elongator subcomplex Elp4-6
J.Biol.Chem., 287, 2012
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4HRV
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4I16
 | | Crystal structure of CARMA1 CARD | | 分子名称: | Caspase recruitment domain-containing protein 11, SULFATE ION | | 著者 | Li, S, Yang, X, Shen, Y. | | 登録日 | 2012-11-20 | | 公開日 | 2012-12-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.751 Å) | | 主引用文献 | Structural insights into the assembly of CARMA1 and BCL10
Plos One, 7, 2012
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5Z6Q
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5Z6R
 | | SPASTIN AAA WITH ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Spastin | | 著者 | Lin, Z, Wang, C, Shen, Y. | | 登録日 | 2018-01-25 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The Aaa Family Protein Spastin Severs A Microtubule
To Be Published
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5YWW
 | | Archael RuvB-like Holiday junction helicase | | 分子名称: | GLYCEROL, Nucleotide binding protein PINc | | 著者 | Zhai, B, Yuan, Z, Han, X, DuPrez, K, Shen, Y, Fan, L. | | 登録日 | 2017-11-30 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction.
Nucleic Acids Res., 46, 2018
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2NZ0
 | | Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 | | 分子名称: | CALCIUM ION, Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 3, ... | | 著者 | Wang, H, Yan, Y, Shen, Y, Chen, L, Wang, K. | | 登録日 | 2006-11-22 | | 公開日 | 2006-12-26 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural basis for modulation of Kv4 K(+) channels by auxiliary KChIP subunits.
Nat.Neurosci., 10, 2007
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6AKI
 | | Calcium release-activated calcium channel protein 1, P288L mutant | | 分子名称: | CHLORIDE ION, Calcium release-activated calcium channel protein 1 | | 著者 | Liu, X, Wu, G, Yang, X, Shen, Y. | | 登録日 | 2018-09-01 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (4.496 Å) | | 主引用文献 | Calcium release-activated calcium channel protein 1, P288L mutant
To Be Published
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2L15
 | | Solution Structure of Cold Shock Protein CspA Using Combined NMR and CS-Rosetta method | | 分子名称: | Cold shock protein CspA | | 著者 | Tang, Y, Schneider, W.M, Shen, Y, Raman, S, Inouye, M, Baker, D, Roth, M.J, Montelione, G.T. | | 登録日 | 2010-07-22 | | 公開日 | 2010-09-15 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Fully automated high-quality NMR structure determination of small (2)H-enriched proteins.
J Struct Funct Genomics, 11, 2010
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7CZB
 | | The cryo-EM structure of the ERAD retrotranslocation channel formed by human Derlin-1 | | 分子名称: | Derlin-1 | | 著者 | Rao, B, Li, S, Yao, D, Wang, Q, Xia, Y, Jia, Y, Shen, Y, Cao, Y. | | 登録日 | 2020-09-07 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1.
Sci Adv, 7, 2021
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7F3X
 | | Lysophospholipid acyltransferase LPCAT3 in complex with lysophosphatidylcholine | | 分子名称: | LPCAT3, [2-((1-OXODODECANOXY-(2-HYDROXY-3-PROPANYL))-PHOSPHONATE-OXY)-ETHYL]-TRIMETHYLAMMONIUM | | 著者 | Zhang, Q, Yao, D, Rao, B, Li, S, Jian, L, Chen, Y, Hu, K, Xia, Y, Shen, Y, Cao, Y. | | 登録日 | 2021-06-17 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3.
Nat Commun, 12, 2021
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7F40
 | | Lysophospholipid acyltransferase LPCAT3 in a complex with Arachidonoyl-CoA | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, LPCAT3, S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate | | 著者 | Zhang, Q, Yao, D, Rao, B, Li, S, Jian, L, Chen, Y, Hu, K, Xia, Y, Shen, Y, Cao, Y. | | 登録日 | 2021-06-17 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3.
Nat Commun, 12, 2021
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2O52
 | | Crystal structure of human RAB4B in complex with GDP | | 分子名称: | BETA-MERCAPTOETHANOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Zhu, H, Tempel, W, Wang, J, Shen, Y, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2006-12-05 | | 公開日 | 2006-12-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of human RAB4B in complex with GDP
To be Published
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