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5K19
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BU of 5k19 by Molmil
Crystal structure of WD repeat-containing protein 20
分子名称: GLYCEROL, SULFATE ION, WD repeat-containing protein 20
著者Li, H, D'Andrea, A.D, Zheng, N.
登録日2016-05-17
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.602 Å)
主引用文献Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
5K1C
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BU of 5k1c by Molmil
Crystal structure of the UAF1/WDR20/USP12 complex
分子名称: PHOSPHATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE, Ubiquitin carboxyl-terminal hydrolase 12, ...
著者Li, H, D'Andrea, A.D, Zheng, N.
登録日2016-05-18
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
3WUU
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BU of 3wuu by Molmil
Structure basis of inactivating cell abscission with chimera peptide 1
分子名称: Centrosomal protein of 55 kDa, TEX-14
著者Kim, H.J, Matsuura, A, Lee, H.H.
登録日2014-05-05
公開日2015-07-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.904 Å)
主引用文献Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells.
Proc.Natl.Acad.Sci.USA, 112, 2015
2XHS
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BU of 2xhs by Molmil
Crystal structure of the ligand binding domain of Fushi tarazu factor 1 of Drosophila melanogaster.
分子名称: NUCLEAR HORMONE RECEPTOR FTZ-F1, SEGMENTATION PROTEIN FUSHI TARAZU
著者Yoo, J.H, Cho, H.S.
登録日2010-06-21
公開日2011-07-20
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Fushi Tarazu Factor 1 Ligand Binding Domain/Fushi Tarazu Peptide Complex Identifies New Class of Nuclear Receptors.
J.Biol.Chem., 286, 2011
8VH5
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BU of 8vh5 by Molmil
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state
分子名称: GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, ...
著者Zhu, H, Sun, J.
登録日2023-12-30
公開日2024-10-09
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.
Nat Commun, 15, 2024
8VH4
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BU of 8vh4 by Molmil
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 monomer state
分子名称: GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, ...
著者Zhu, H, Sun, J.
登録日2023-12-30
公開日2024-10-09
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.
Nat Commun, 15, 2024
7CHT
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BU of 7cht by Molmil
Crystal structure of TTK kinase domain in complex with compound 30
分子名称: 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(oxan-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK, MAGNESIUM ION
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Ko, E.H, Choi, H.G, Son, J.B, Kim, N.D.
登録日2020-07-06
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CHM
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BU of 7chm by Molmil
Crystal structure of TTK kinase domain in complex with compound 8
分子名称: 4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-06
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CHN
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BU of 7chn by Molmil
Crystal structure of TTK kinase domain in complex with compound 9
分子名称: 4-(cyclohexylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-06
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CLH
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BU of 7clh by Molmil
Crystal structure of TTK kinase domain in complex with compound 19
分子名称: 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-21
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CJA
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BU of 7cja by Molmil
Crystal structure of TTK kinase domain in complex with compound 28
分子名称: 4-(cyclopentylmethylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-09
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
7CIL
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BU of 7cil by Molmil
Crystal structure of TTK kinase domain in complex with compound 7
分子名称: 4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK
著者Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D.
登録日2020-07-07
公開日2021-05-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.
J.Med.Chem., 64, 2021
3P2F
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BU of 3p2f by Molmil
Crystal structure of TofI in an apo form
分子名称: AHL synthase
著者Yu, S, Rhee, S.
登録日2010-10-02
公開日2011-07-06
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase
Proc.Natl.Acad.Sci.USA, 108, 2011
3P2H
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BU of 3p2h by Molmil
Crystal structure of TofI in a ternary complex with an inhibitor and MTA
分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, AHL synthase, N-(3-oxocyclohex-1-en-1-yl)octanamide
著者Yu, S, Rhee, S.
登録日2010-10-02
公開日2011-07-06
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase
Proc.Natl.Acad.Sci.USA, 108, 2011
6USY
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BU of 6usy by Molmil
COAGULATION FACTOR XI CATALYTIC DOMAIN (C123S) IN COMPLEX WITH NVP-XIV936
分子名称: 1-[(2S)-2-{3-[(3S)-3-amino-2,3-dihydro-1-benzofuran-5-yl]-5-(propan-2-yl)phenyl}-2-hydroxyethyl]-1H-indole-7-carboxylic acid, Coagulation factor XIa light chain
著者Weihofen, W.A, Clark, K, Nunes, S.
登録日2019-10-28
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J.Med.Chem., 63, 2020
6KBM
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BU of 6kbm by Molmil
Crystal structure of Vac8 bound to Atg13
分子名称: Autophagy-related protein 13, Vacuolar protein 8
著者Park, J, Lee, C.
登録日2019-06-25
公開日2019-11-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.902 Å)
主引用文献Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways.
Autophagy, 16, 2020
6KBN
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BU of 6kbn by Molmil
Crystal structure of Vac8 (del 19-33) bound to Atg13
分子名称: Autophagy-related protein 13, Vacuolar protein 8
著者Park, J, Lee, C.
登録日2019-06-25
公開日2019-11-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways.
Autophagy, 16, 2020
3SH4
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BU of 3sh4 by Molmil
Laminin G like domain 3 from human perlecan
分子名称: LG3 peptide
著者Van Le, B, Kim, K.K.
登録日2011-06-15
公開日2011-12-14
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor.
J.Mol.Biol., 414, 2011
3SH5
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BU of 3sh5 by Molmil
Calcium-bound Laminin G like domain 3 from human perlecan
分子名称: CALCIUM ION, LG3 peptide
著者Van Le, B, Kim, K.K.
登録日2011-06-16
公開日2011-12-14
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the LG3 Domain of Endorepellin, an Angiogenesis Inhibitor.
J.Mol.Biol., 414, 2011
6XJF
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BU of 6xjf by Molmil
X-ray crystal structure of Pyrococcus furiosus general transcription factor TFE-alpha (SeMet labeled protein)
分子名称: Transcription factor E
著者Murakami, K.S, Jun, S.H.
登録日2020-06-23
公開日2020-07-08
最終更新日2021-01-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase.
Nat Commun, 11, 2020
7EC7
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BU of 7ec7 by Molmil
Crystal structure of SdgB (complexed with phosphate ions)
分子名称: Glycosyl transferase, group 1 family protein, PHOSPHATE ION
著者Kim, D.-G, Baek, I, Lee, Y, Kim, H.S.
登録日2021-03-11
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol, 77, 2021
7EC6
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BU of 7ec6 by Molmil
Crystal structure of SdgB (complexed with peptides)
分子名称: ASP-SER-ASP, Glycosyl transferase, group 1 family protein
著者Kim, D.-G, Baek, I, Lee, Y, Kim, H.S.
登録日2021-03-11
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol, 77, 2021
7EC3
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BU of 7ec3 by Molmil
Crystal structure of SdgB (complexed with UDP, GlcNAc, and Glycosylated peptide)
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-35)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-65)]5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycosyl transferase, ...
著者Kim, D.-G, Baek, I, Lee, Y, Kim, H.S.
登録日2021-03-11
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol, 77, 2021
6XDM
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BU of 6xdm by Molmil
STRUCTURE OF HUMAN HDAC2 IN COMPLEX WITH AN ARYL KETONE INHIBITOR
分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Histone deacetylase 2, ...
著者Klein, D.J, Liu, J.
登録日2020-06-11
公開日2020-07-29
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.
Acs Med.Chem.Lett., 11, 2020
7EC1
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BU of 7ec1 by Molmil
Crystal structure of SdgB (ligand-free form)
分子名称: GLYCEROL, Glycosyl transferase, group 1 family protein, ...
著者Kim, D.-G, Baek, I, Lee, Y, Kim, H.S.
登録日2021-03-11
公開日2021-03-24
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins.
Acta Crystallogr D Struct Biol, 77, 2021

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