7VD4
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![BU of 7vd4 by Molmil](/molmil-images/mine/7vd4) | Crystal structure of BPTF-BRD with ligand TP248 bound | 分子名称: | 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | 著者 | Lu, T, Lu, H.B. | 登録日 | 2021-09-06 | 公開日 | 2022-09-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85659146 Å) | 主引用文献 | Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold. Bioorg.Chem., 123, 2022
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7KXT
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![BU of 7kxt by Molmil](/molmil-images/mine/7kxt) | Crystal structure of human EED | 分子名称: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Polycomb protein EED, UNKNOWN ATOM OR ION | 著者 | Zhu, L, Dong, A, Du, D, Liu, Y, Luo, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2020-12-04 | 公開日 | 2021-02-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J.Med.Chem., 64, 2021
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8JUE
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![BU of 8jue by Molmil](/molmil-images/mine/8jue) | Crystal structure of glutaminase C in complex with compound 11 | 分子名称: | 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | 著者 | Wang, X, Hanyu, S, Tingting, D. | 登録日 | 2023-06-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
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8JUB
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![BU of 8jub by Molmil](/molmil-images/mine/8jub) | Crystal structure of glutaminase C in complex with compound 27 | 分子名称: | 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial | 著者 | Wang, X, Hanyu, S, Tingting, D. | 登録日 | 2023-06-26 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
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8G2O
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![BU of 8g2o by Molmil](/molmil-images/mine/8g2o) | Fab structure - Anti-ApoE-7C11 antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, anti-ApoE-7C11 heavy chain, anti-ApoE-7C11 light chain | 著者 | Marino, C, Arboleda-Velasquez, J.F. | 登録日 | 2023-02-06 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation. Alzheimers Dement, 20, 2024
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1PC4
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![BU of 1pc4 by Molmil](/molmil-images/mine/1pc4) | Crystal Structure of the P50A mutant of ferredoxin I at 1.65 A Resolution | 分子名称: | FE3-S4 CLUSTER, Ferredoxin I, IRON/SULFUR CLUSTER | 著者 | Camba, R, Jung, Y.S, Chen, K, Hunsicker-Wang, L.M, Burgess, B.K, Stout, C.D, Hirst, J, Armstrong, F.A. | 登録日 | 2003-05-15 | 公開日 | 2003-09-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Mechanisms of redox-coupled proton transfer in proteins: role of the proximal proline in reactions of the [3Fe-4S] cluster in Azotobacter vinelandii ferredoxin I Biochemistry, 42, 2003
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1PC5
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![BU of 1pc5 by Molmil](/molmil-images/mine/1pc5) | Crystal Structure of the P50G Mutant of Ferredoxin I at 1.8 A Resolution | 分子名称: | FE3-S4 CLUSTER, Ferredoxin I, IRON/SULFUR CLUSTER | 著者 | Camba, R, Jung, Y.S, Chen, K, Hunsicker-Wang, L.M, Burgess, B.K, Stout, C.D, Hirst, J, Armstrong, F.A. | 登録日 | 2003-05-15 | 公開日 | 2003-09-30 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanisms of redox-coupled proton transfer in proteins: role of the proximal proline in reactions of the [3Fe-4S] cluster in Azotobacter vinelandii ferredoxin I Biochemistry, 42, 2003
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7F30
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![BU of 7f30 by Molmil](/molmil-images/mine/7f30) | Crystal structure of OxdB E85A in complex with Z-2- (3-bromophenyl) propanal oxime | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Phenylacetaldoxime dehydratase, Z-2-(3-bromophenyl) propanal oxime | 著者 | Muraki, N, Matsui, D, Asano, Y, Aono, S. | 登録日 | 2021-06-15 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structural analysis of aldoxime dehydratase from Bacillus sp. OxB-1: Importance of surface residues in optimization for crystallization. J.Inorg.Biochem., 230, 2022
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7F2Y
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![BU of 7f2y by Molmil](/molmil-images/mine/7f2y) | Crystal structure of OxdB E85A mutant (form I) | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Phenylacetaldoxime dehydratase | 著者 | Muraki, N, Matsui, D, Asano, Y, Aono, S. | 登録日 | 2021-06-15 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Crystal structural analysis of aldoxime dehydratase from Bacillus sp. OxB-1: Importance of surface residues in optimization for crystallization. J.Inorg.Biochem., 230, 2022
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7F2Z
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![BU of 7f2z by Molmil](/molmil-images/mine/7f2z) | Crystal structure of OxdB E85A mutant (form II) | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Phenylacetaldoxime dehydratase | 著者 | Muraki, N, Matsui, D, Asano, Y, Aono, S. | 登録日 | 2021-06-15 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structural analysis of aldoxime dehydratase from Bacillus sp. OxB-1: Importance of surface residues in optimization for crystallization. J.Inorg.Biochem., 230, 2022
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6ALC
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![BU of 6alc by Molmil](/molmil-images/mine/6alc) | CREBBP bromodomain in complex with Cpd 4 (1-(1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) | 分子名称: | 1,2-ETHANEDIOL, 1-[1-(cyclopropylmethyl)-3-(1H-indol-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]ethan-1-one, CREB-binding protein, ... | 著者 | Murray, J.M. | 登録日 | 2017-08-07 | 公開日 | 2018-08-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.391 Å) | 主引用文献 | Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300. Bioorg. Med. Chem. Lett., 28, 2018
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4EO7
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![BU of 4eo7 by Molmil](/molmil-images/mine/4eo7) | Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88. | 分子名称: | MAGNESIUM ION, Myeloid differentiation primary response protein MyD88 | 著者 | Snyder, G.A, Cirl, C, Jiang, J.S, Chen, P, Smith, T, Xiao, T.S. | 登録日 | 2012-04-13 | 公開日 | 2013-04-10 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.449 Å) | 主引用文献 | Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proc.Natl.Acad.Sci.USA, 110, 2013
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6KW3
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![BU of 6kw3 by Molmil](/molmil-images/mine/6kw3) | The ClassA RSC-Nucleosome Complex | 分子名称: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... | 著者 | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | 登録日 | 2019-09-05 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (7.13 Å) | 主引用文献 | Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
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6KW4
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![BU of 6kw4 by Molmil](/molmil-images/mine/6kw4) | The ClassB RSC-Nucleosome Complex | 分子名称: | Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC3, ... | 著者 | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | 登録日 | 2019-09-06 | 公開日 | 2019-11-13 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (7.55 Å) | 主引用文献 | Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
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6K15
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![BU of 6k15 by Molmil](/molmil-images/mine/6k15) | RSC substrate-recruitment module | 分子名称: | Chromatin structure-remodeling complex protein RSC3, Chromatin structure-remodeling complex protein RSC30, Chromatin structure-remodeling complex protein RSC58, ... | 著者 | Ye, Y.P, Wu, H, Chen, K.J, Verma, N, Cairns, B, Gao, N, Chen, Z.C. | 登録日 | 2019-05-09 | 公開日 | 2019-11-13 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of the RSC complex bound to the nucleosome. Science, 366, 2019
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7YP1
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![BU of 7yp1 by Molmil](/molmil-images/mine/7yp1) | Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 10E4 (localized refinement) | 分子名称: | 10E4 heavy chain, 10E4 light chain, EBV gH, ... | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | 登録日 | 2022-08-02 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023
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7YOY
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![BU of 7yoy by Molmil](/molmil-images/mine/7yoy) | Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement) | 分子名称: | 3E8 heavy chain, 3E8 light chain, 5E3 heavy chain, ... | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | 登録日 | 2022-08-02 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023
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7YP2
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![BU of 7yp2 by Molmil](/molmil-images/mine/7yp2) | Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement) | 分子名称: | 6H2 heavy chain, 6H2 light chain, Envelope glycoprotein H | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | 登録日 | 2022-08-02 | 公開日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Cell Rep Med, 4, 2023
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7X3X
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![BU of 7x3x by Molmil](/molmil-images/mine/7x3x) | Cryo-EM structure of N1 nucleosome-RA | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3T
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![BU of 7x3t by Molmil](/molmil-images/mine/7x3t) | Cryo-EM structure of ISW1a-dinucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (343-MER), ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3W
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![BU of 7x3w by Molmil](/molmil-images/mine/7x3w) | Cryo-EM structure of ISW1-N1 nucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (146-MER), ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7X3V
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![BU of 7x3v by Molmil](/molmil-images/mine/7x3v) | Cryo-EM structure of IOC3-N2 nucleosome | 分子名称: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Lifei, L, Kangjing, C, Chen, Z. | 登録日 | 2022-03-01 | 公開日 | 2023-09-20 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
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7ENN
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![BU of 7enn by Molmil](/molmil-images/mine/7enn) | The structure of ALC1 bound to the nucleosome | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromodomain-helicase-DNA-binding protein 1-like, ... | 著者 | Chen, Z.C, Chen, K.J, Wang, L. | 登録日 | 2021-04-18 | 公開日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Nat Commun, 12, 2021
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6K05
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![BU of 6k05 by Molmil](/molmil-images/mine/6k05) | Crystal structure of BRD2(BD1)with ligand BY27 bound | 分子名称: | (6~{R})-~{N}-(4-chlorophenyl)-1-methyl-8-(1-methylpyrazol-4-yl)-5,6-dihydro-4~{H}-[1,2,4]triazolo[4,3-a][1]benzazepin-6-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bromodomain-containing protein 2 | 著者 | Lu, T, Lu, W, Chen, D, Zhao, Y, Luo, C. | 登録日 | 2019-05-05 | 公開日 | 2019-09-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.935 Å) | 主引用文献 | Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins. Eur.J.Med.Chem., 182, 2019
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6K04
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![BU of 6k04 by Molmil](/molmil-images/mine/6k04) | Crystal structure of BRD2(BD2)with ligand BY27 bound | 分子名称: | (6~{R})-~{N}-(4-chlorophenyl)-1-methyl-8-(1-methylpyrazol-4-yl)-5,6-dihydro-4~{H}-[1,2,4]triazolo[4,3-a][1]benzazepin-6-amine, Bromodomain-containing protein 2 | 著者 | Lu, T, Lu, W, Chen, D, Zhao, Y, Luo, C. | 登録日 | 2019-05-05 | 公開日 | 2019-09-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.251 Å) | 主引用文献 | Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins. Eur.J.Med.Chem., 182, 2019
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