8G2O
Fab structure - Anti-ApoE-7C11 antibody
Summary for 8G2O
Entry DOI | 10.2210/pdb8g2o/pdb |
Descriptor | anti-ApoE-7C11 heavy chain, anti-ApoE-7C11 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | antibody, apoe, fab, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 48542.82 |
Authors | Marino, C.,Arboleda-Velasquez, J.F. (deposition date: 2023-02-06, release date: 2023-10-18, Last modification date: 2024-02-28) |
Primary citation | Marino, C.,Perez-Corredor, P.,O'Hare, M.,Heuer, A.,Chmielewska, N.,Gordon, H.,Chandrahas, A.S.,Gonzalez-Buendia, L.,Delgado-Tirado, S.,Doan, T.H.,Vanderleest, T.E.,Arevalo-Alquichire, S.,Obar, R.A.,Ortiz-Cordero, C.,Villegas, A.,Sepulveda-Falla, D.,Kim, L.A.,Lopera, F.,Mahley, R.,Huang, Y.,Quiroz, Y.T.,Arboleda-Velasquez, J.F. APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation. Alzheimers Dement, 20:819-836, 2024 Cited by PubMed: 37791598DOI: 10.1002/alz.13436 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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