6K05
Crystal structure of BRD2(BD1)with ligand BY27 bound
Summary for 6K05
Entry DOI | 10.2210/pdb6k05/pdb |
Descriptor | Bromodomain-containing protein 2, (6~{R})-~{N}-(4-chlorophenyl)-1-methyl-8-(1-methylpyrazol-4-yl)-5,6-dihydro-4~{H}-[1,2,4]triazolo[4,3-a][1]benzazepin-6-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | antitumor; bet proteins; bromodomain inhibitor; epigenetic readers, antitumor protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 44420.63 |
Authors | |
Primary citation | Chen, D.,Lu, T.,Yan, Z.,Lu, W.,Zhou, F.,Lyu, X.,Xu, B.,Jiang, H.,Chen, K.,Luo, C.,Zhao, Y. Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins. Eur.J.Med.Chem., 182:111633-111633, 2019 Cited by PubMed: 31461688DOI: 10.1016/j.ejmech.2019.111633 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.935 Å) |
Structure validation
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