6T7V
 
 | | KEAP1 IN COMPLEX WITH PEPTIDE 8 | | 分子名称: | ACETATE ION, Kelch-like ECH-associated protein 1, LEU-ASP-PRO-GLU-THR-GLY-GLU-PHE-LEU | | 著者 | Colarusso, S. | | 登録日 | 2019-10-23 | | 公開日 | 2020-09-09 | | 最終更新日 | 2020-10-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Bioorg.Med.Chem., 28, 2020
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8PI1
 | | Bicyclic INCYPRO Pseudomonas fluorescens esterase | | 分子名称: | Arylesterase, GLYCEROL, N-[2-[3,5-bis[2-(2-iodanylethanoylamino)ethanoyl]-1,3,5-triazinan-1-yl]-2-oxidanylidene-ethyl]-2-iodanyl-ethanamide | | 著者 | Kiehstaller, S, Pearce, N.M, Grossmann, T.N, Hennig, S. | | 登録日 | 2023-06-20 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Covalent bicyclization of protein complexes yields durable quaternary structures.
Chem, 10, 2024
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3HWN
 | | CATHEPSIN L with AZ13010160 | | 分子名称: | Cathepsin L1, Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2E)-2-iminoethyl]-3-{5-[(Z)-iminomethyl]-1,3,4-oxadiazol-2-yl}-L-phenylalaninamide | | 著者 | Kenny, P, Morley, A. | | 登録日 | 2009-06-18 | | 公開日 | 2009-09-15 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Design of selective Cathepsin inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
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5HAX
 | | Crystal structure of Chaetomium thermophilum Nup170 NTD-Nup53 complex | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Nucleoporin NUP170, ... | | 著者 | Lin, D.H, Mobbs, G, Hoelz, A. | | 登録日 | 2015-12-31 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Architecture of the symmetric core of the nuclear pore.
Science, 352, 2016
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5HB6
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5HAY
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5HB1
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5HB7
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5HB0
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5HB3
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5HB4
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5HAZ
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5HB8
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5HB5
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4BB4
 | | ephB4 kinase domain inhibitor complex | | 分子名称: | EPHRIN TYPE-B RECEPTOR 4, MAGNESIUM ION, N-(2-methoxyethyl)-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide | | 著者 | Read, J, Brassington, C.A, Green, I, McCall, E.J, Valentine, A.L. | | 登録日 | 2012-09-19 | | 公開日 | 2013-02-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Discovery and Optimization of a Novel Series of Potent Mutant B-Raf V600E Selective Kinase Inhibitors.
J.Med.Chem., 56, 2013
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8SWH
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5E1E
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6EWX
 | | Structure of Pragmin pseudo-kinase reveals a dimerization mechanism to regulate protein tyrosine phosphorylation and nuclear transcription | | 分子名称: | PEAK1-related kinase-activating pseudokinase 1, SULFATE ION | | 著者 | Gelin, M, Allemand, F, Fournet, A, Labesse, G. | | 登録日 | 2017-11-06 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.771 Å) | | 主引用文献 | Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.
Structure, 26, 2018
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8CHW
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8CHT
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8CHV
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8CHU
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4GV1
 | | PKB alpha in complex with AZD5363 | | 分子名称: | 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, GLYCEROL, RAC-alpha serine/threonine-protein kinase | | 著者 | Addie, M, Ballard, P, Bird, G, Buttar, D, Currie, G, Davies, B, Debreczeni, J, Dry, H, Dudley, P, Greenwood, R, Hatter, G, Jestel, A, Johnson, P.D, Kettle, J.G, Lane, C, Lamont, G, Leach, A, Luke, R.W.A, Ogilvie, D, Page, K, Pass, M, Steinbacher, S, Steuber, H, Pearson, S, Ruston, L. | | 登録日 | 2012-08-30 | | 公開日 | 2013-02-27 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases.
J.Med.Chem., 56, 2013
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8TL0
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2N8D
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