2F5J
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8Q91
| Structure of the human 20S U5 snRNP core | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Schneider, S, Galej, W.P. | 登録日 | 2023-08-19 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the human 20S U5 snRNP. Nat.Struct.Mol.Biol., 31, 2024
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8RC0
| Structure of the human 20S U5 snRNP | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Schneider, S, Galej, W.P. | 登録日 | 2023-12-05 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of the human 20S U5 snRNP. Nat.Struct.Mol.Biol., 31, 2024
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8H0Z
| Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Locked-122 Conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | 著者 | Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X. | 登録日 | 2022-09-30 | 公開日 | 2022-11-09 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Life Sci Alliance, 6, 2023
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3H59
| Hepatitis C virus polymerase NS5B with thiazine inhibitor 2 | 分子名称: | N-{3-[(5S)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | 著者 | Harris, S.F, Ghate, M. | 登録日 | 2009-04-21 | 公開日 | 2009-09-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids Bioorg.Med.Chem.Lett., 19, 2009
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6KXW
| Crystal structure of human aquaporin AQP7 in bound to glycerol | 分子名称: | Aquaporin-7, GLYCEROL | 著者 | Zhang, L, Yao, D, Zhou, F, Zhang, Q, Zhou, L, Cao, Y. | 登録日 | 2019-09-13 | 公開日 | 2019-11-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | The structural basis for glycerol permeation by human AQP7 Sci Bull (Beijing), 66, 2020
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6M03
| The crystal structure of COVID-19 main protease in apo form | 分子名称: | 3C-like proteinase | 著者 | Zhang, B, Zhao, Y, Jin, Z, Liu, X, Yang, H, Rao, Z. | 登録日 | 2020-02-19 | 公開日 | 2020-03-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 119, 2022
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8IYX
| Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365 | 分子名称: | 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365 | 著者 | Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M. | 登録日 | 2023-04-06 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
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5YS1
| Crystal structure of Multicopper Oxidase CueO G304K mutant | 分子名称: | Blue copper oxidase CueO, COPPER (II) ION | 著者 | Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y. | 登録日 | 2017-11-12 | 公開日 | 2018-10-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity Sci Rep, 8, 2018
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5YS5
| Crystal structure of Multicopper Oxidase CueO G304K mutant with seven copper ions | 分子名称: | Blue copper oxidase CueO, COPPER (II) ION | 著者 | Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y. | 登録日 | 2017-11-13 | 公開日 | 2018-10-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity Sci Rep, 8, 2018
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6K13
| Crystal Structure Basis for BmLDH Complex | 分子名称: | L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID | 著者 | Long, Y, Shen, Z. | 登録日 | 2019-05-09 | 公開日 | 2019-10-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal structures ofBabesia microtilactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis. Faseb J., 33, 2019
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7V42
| Crystal structure of Class I P450 monooxygenase (P450tol) from Rhodococcus coprophilus TC-2 in complex with benzyl-alcohol. | 分子名称: | PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, p450tol monooxygenase, ... | 著者 | Zhang, L.L, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2021-08-12 | 公開日 | 2022-06-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Molecular Basis for a Toluene Monooxygenase to Govern Substrate Selectivity Acs Catalysis, 12, 2022
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7V40
| Crystal structure of Class I P450 monooxygenase (P450tol) from Rhodococcus coprophilus TC-2 | 分子名称: | PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, p450tol monooxygenase | 著者 | Zhang, L.L, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2021-08-12 | 公開日 | 2022-06-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Molecular Basis for a Toluene Monooxygenase to Govern Substrate Selectivity Acs Catalysis, 12, 2022
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6K12
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6J9D
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3H2L
| Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor | 分子名称: | N-{3-[(4aR,7aS)-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, NS5B polymerase | 著者 | Han, Q, Showalter, R.E, Zhou, Q, Kissinger, C.R. | 登録日 | 2009-04-14 | 公開日 | 2009-12-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
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6WC5
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6WC2
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8T5K
| Crystal structure of STING CTD in complex with BDW-OH | 分子名称: | Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid | 著者 | Li, Y, Li, P, Sun, D. | 登録日 | 2023-06-13 | 公開日 | 2023-07-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants. Biorxiv, 2023
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8T5L
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5DRP
| Structure of the AaLpxC/LPC-023 Complex | 分子名称: | CHLORIDE ION, DIMETHYL SULFOXIDE, N~2~-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-isoleucinamide, ... | 著者 | Najeeb, J, Lee, C.-J, Zhou, P. | 登録日 | 2015-09-16 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.889 Å) | 主引用文献 | Drug design from the cryptic inhibitor envelope. Nat Commun, 7, 2016
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5DRR
| Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-058 complex | 分子名称: | 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide, NITRATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Lee, C.-J, Najeeb, J, Zhou, P. | 登録日 | 2015-09-16 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Drug design from the cryptic inhibitor envelope. Nat Commun, 7, 2016
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6C13
| CryoEM structure of mouse PCDH15-4EC-LHFPL5 complex | 分子名称: | Protocadherin-15, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Gouaux, E, Ge, J, Elferich, J. | 登録日 | 2018-01-03 | 公開日 | 2018-08-15 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (11.33 Å) | 主引用文献 | Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5. Elife, 7, 2018
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5DRO
| Structure of the Aquifex aeolicus LpxC/LPC-011 Complex | 分子名称: | 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]benzamide, ACETATE ION, DIMETHYL SULFOXIDE, ... | 著者 | Lee, C.-J, Najeeb, J, Zhou, P. | 登録日 | 2015-09-16 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Drug design from the cryptic inhibitor envelope. Nat Commun, 7, 2016
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6C10
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