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2F5J
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BU of 2f5j by Molmil
Crystal structure of MRG domain from human MRG15
分子名称: Mortality factor 4-like protein 1
著者Zhang, P, Du, J, Ding, J.
登録日2005-11-26
公開日2006-11-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14
Protein Sci., 15, 2006
8Q91
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BU of 8q91 by Molmil
Structure of the human 20S U5 snRNP core
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Schneider, S, Galej, W.P.
登録日2023-08-19
公開日2024-03-27
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
8RC0
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BU of 8rc0 by Molmil
Structure of the human 20S U5 snRNP
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, CD2 antigen cytoplasmic tail-binding protein 2, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Schneider, S, Galej, W.P.
登録日2023-12-05
公開日2024-03-27
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the human 20S U5 snRNP.
Nat.Struct.Mol.Biol., 31, 2024
8H0Z
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BU of 8h0z by Molmil
Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Locked-122 Conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ...
著者Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X.
登録日2022-09-30
公開日2022-11-09
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
Life Sci Alliance, 6, 2023
3H59
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BU of 3h59 by Molmil
Hepatitis C virus polymerase NS5B with thiazine inhibitor 2
分子名称: N-{3-[(5S)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase
著者Harris, S.F, Ghate, M.
登録日2009-04-21
公開日2009-09-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids
Bioorg.Med.Chem.Lett., 19, 2009
6KXW
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BU of 6kxw by Molmil
Crystal structure of human aquaporin AQP7 in bound to glycerol
分子名称: Aquaporin-7, GLYCEROL
著者Zhang, L, Yao, D, Zhou, F, Zhang, Q, Zhou, L, Cao, Y.
登録日2019-09-13
公開日2019-11-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献The structural basis for glycerol permeation by human AQP7
Sci Bull (Beijing), 66, 2020
6M03
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BU of 6m03 by Molmil
The crystal structure of COVID-19 main protease in apo form
分子名称: 3C-like proteinase
著者Zhang, B, Zhao, Y, Jin, Z, Liu, X, Yang, H, Rao, Z.
登録日2020-02-19
公開日2020-03-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2.
Proc.Natl.Acad.Sci.USA, 119, 2022
8IYX
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BU of 8iyx by Molmil
Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365
分子名称: 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365
著者Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M.
登録日2023-04-06
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc.Natl.Acad.Sci.USA, 120, 2023
5YS1
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BU of 5ys1 by Molmil
Crystal structure of Multicopper Oxidase CueO G304K mutant
分子名称: Blue copper oxidase CueO, COPPER (II) ION
著者Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y.
登録日2017-11-12
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity
Sci Rep, 8, 2018
5YS5
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BU of 5ys5 by Molmil
Crystal structure of Multicopper Oxidase CueO G304K mutant with seven copper ions
分子名称: Blue copper oxidase CueO, COPPER (II) ION
著者Wang, H.Q, Liu, X.Q, Zhao, J.T, Yue, Q.X, Yan, Y.H, Dong, Y.H, Fan, Y.L, Tian, J, Wu, N.F, Gong, Y.
登録日2017-11-13
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of multicopper oxidase CueO G304K mutant: structural basis of the increased laccase activity
Sci Rep, 8, 2018
6K13
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BU of 6k13 by Molmil
Crystal Structure Basis for BmLDH Complex
分子名称: L-lactate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID
著者Long, Y, Shen, Z.
登録日2019-05-09
公開日2019-10-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal structures ofBabesia microtilactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.
Faseb J., 33, 2019
7V42
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BU of 7v42 by Molmil
Crystal structure of Class I P450 monooxygenase (P450tol) from Rhodococcus coprophilus TC-2 in complex with benzyl-alcohol.
分子名称: PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, p450tol monooxygenase, ...
著者Zhang, L.L, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T.
登録日2021-08-12
公開日2022-06-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Molecular Basis for a Toluene Monooxygenase to Govern Substrate Selectivity
Acs Catalysis, 12, 2022
7V40
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BU of 7v40 by Molmil
Crystal structure of Class I P450 monooxygenase (P450tol) from Rhodococcus coprophilus TC-2
分子名称: PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, p450tol monooxygenase
著者Zhang, L.L, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T.
登録日2021-08-12
公開日2022-06-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Molecular Basis for a Toluene Monooxygenase to Govern Substrate Selectivity
Acs Catalysis, 12, 2022
6K12
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BU of 6k12 by Molmil
Babesia microti lactate dehydrogenase apo form (BmLDH)
分子名称: L-lactate dehydrogenase
著者Long, Y.
登録日2019-05-09
公開日2019-10-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.794 Å)
主引用文献Crystal structures ofBabesia microtilactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.
Faseb J., 33, 2019
6J9D
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BU of 6j9d by Molmil
Babesia microti lactate dehydrogenase R99A (BmLDHR99A)
分子名称: L-lactate dehydrogenase
著者Yu, L.
登録日2019-01-22
公開日2019-10-16
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.904 Å)
主引用文献Crystal structures ofBabesia microtilactate dehydrogenase BmLDH reveal a critical role for Arg99 in catalysis.
Faseb J., 33, 2019
3H2L
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BU of 3h2l by Molmil
Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor
分子名称: N-{3-[(4aR,7aS)-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, NS5B polymerase
著者Han, Q, Showalter, R.E, Zhou, Q, Kissinger, C.R.
登録日2009-04-14
公開日2009-12-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Bioorg.Med.Chem.Lett., 19, 2009
6WC5
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BU of 6wc5 by Molmil
Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex
分子名称: Homeobox protein Nkx-2.5, Myocardin enhancer DNA, Myocyte-specific enhancer factor 2B
著者Chen, L, Lei, X.
登録日2020-03-29
公開日2020-07-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
J.Mol.Biol., 432, 2020
6WC2
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BU of 6wc2 by Molmil
Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex
分子名称: Homeobox protein Nkx-2.5, MEF2 Chimera,Myocyte-specific enhancer factor 2B,Myocyte-specific enhancer factor 2A, Myocardin Enhancer DNA
著者Lei, X, Chen, L.
登録日2020-03-29
公開日2020-07-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
J.Mol.Biol., 432, 2020
8T5K
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BU of 8t5k by Molmil
Crystal structure of STING CTD in complex with BDW-OH
分子名称: Stimulator of interferon genes protein, {[(4S)-8,9-dimethylthieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3-yl]sulfanyl}acetic acid
著者Li, Y, Li, P, Sun, D.
登録日2023-06-13
公開日2023-07-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
8T5L
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BU of 8t5l by Molmil
Crystal structure of STING CTD in complex with 2'3'-cGAMP
分子名称: Stimulator of interferon genes protein, cGAMP
著者Li, Y, Li, P, Sun, D.
登録日2023-06-13
公開日2023-07-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
5DRP
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BU of 5drp by Molmil
Structure of the AaLpxC/LPC-023 Complex
分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, N~2~-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-isoleucinamide, ...
著者Najeeb, J, Lee, C.-J, Zhou, P.
登録日2015-09-16
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.889 Å)
主引用文献Drug design from the cryptic inhibitor envelope.
Nat Commun, 7, 2016
5DRR
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BU of 5drr by Molmil
Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-058 complex
分子名称: 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]benzamide, NITRATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ...
著者Lee, C.-J, Najeeb, J, Zhou, P.
登録日2015-09-16
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Drug design from the cryptic inhibitor envelope.
Nat Commun, 7, 2016
6C13
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BU of 6c13 by Molmil
CryoEM structure of mouse PCDH15-4EC-LHFPL5 complex
分子名称: Protocadherin-15, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Gouaux, E, Ge, J, Elferich, J.
登録日2018-01-03
公開日2018-08-15
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (11.33 Å)
主引用文献Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
5DRO
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BU of 5dro by Molmil
Structure of the Aquifex aeolicus LpxC/LPC-011 Complex
分子名称: 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]benzamide, ACETATE ION, DIMETHYL SULFOXIDE, ...
著者Lee, C.-J, Najeeb, J, Zhou, P.
登録日2015-09-16
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Drug design from the cryptic inhibitor envelope.
Nat Commun, 7, 2016
6C10
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BU of 6c10 by Molmil
Crystal structure of mouse PCDH15 EC11-EL
分子名称: Protocadherin-15, alpha-D-mannopyranose
著者Gouaux, E, Elferich, J, Ge, J.
登録日2018-01-03
公開日2018-08-15
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.399 Å)
主引用文献Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018

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