7WPS
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![BU of 7wps by Molmil](/molmil-images/mine/7wps) | Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (7 units) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, von Willebrand antigen 2, ... | 著者 | Zeng, J.W, Shu, Z.M, Zhou, A.W. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (4.32 Å) | 主引用文献 | Structural basis of von Willebrand factor multimerization and tubular storage. Blood, 139, 2022
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7WPR
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![BU of 7wpr by Molmil](/molmil-images/mine/7wpr) | VWF D'D3 dimer complexed with D1D2 at 4.39 angstron resolution(VWF tube) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, von Willebrand antigen 2, ... | 著者 | Zeng, J.W, Shu, Z.M, Zhou, A.W. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2022-06-15 | 実験手法 | ELECTRON MICROSCOPY (4.39 Å) | 主引用文献 | Structural basis of von Willebrand factor multimerization and tubular storage. Blood, 139, 2022
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2K1H
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![BU of 2k1h by Molmil](/molmil-images/mine/2k1h) | Solution NMR structure of SeR13 from Staphylococcus epidermidis. Northeast Structural Genomics Consortium target SeR13 | 分子名称: | Uncharacterized protein SeR13 | 著者 | Lee, H, Wylie, G, Bansal, S, Wang, X, Shastry, R, Jiang, M, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-03-05 | 公開日 | 2008-03-18 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of SeR13. To be Published
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8HNK
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![BU of 8hnk by Molmil](/molmil-images/mine/8hnk) | CXCR3-DNGi complex activated by CXCL11 | 分子名称: | C-X-C motif chemokine 11, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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8HNN
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![BU of 8hnn by Molmil](/molmil-images/mine/8hnn) | Structure of CXCR3 complexed with antagonist SCH546738 | 分子名称: | 3-azanyl-6-chloranyl-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide, CHOLESTEROL, Nb6, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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8HNL
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![BU of 8hnl by Molmil](/molmil-images/mine/8hnl) | CXCR3-DNGi complex activated by PS372424 | 分子名称: | (3S)-N-[(2S)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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8HNM
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![BU of 8hnm by Molmil](/molmil-images/mine/8hnm) | CXCR3-DNGi complex activated by VUF11222 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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8H93
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![BU of 8h93 by Molmil](/molmil-images/mine/8h93) | Structure of dimeric mouse SCMC core complex | 分子名称: | NACHT, LRR and PYD domains-containing protein 5, Oocyte-expressed protein homolog, ... | 著者 | Chi, P, Ou, G, Han, Z, Li, J, Deng, D. | 登録日 | 2022-10-24 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural basis of the subcortical maternal complex and its implications in reproductive disorders. Nat.Struct.Mol.Biol., 31, 2024
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8H94
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![BU of 8h94 by Molmil](/molmil-images/mine/8h94) | Structure of mouse SCMC bound with KH domain of FILIA | 分子名称: | NACHT, LRR and PYD domains-containing protein 5, Oocyte-expressed protein homolog, ... | 著者 | Chi, P, Ou, G, Han, Z, Li, J, Deng, D. | 登録日 | 2022-10-24 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of the subcortical maternal complex and its implications in reproductive disorders. Nat.Struct.Mol.Biol., 31, 2024
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8H96
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![BU of 8h96 by Molmil](/molmil-images/mine/8h96) | Structure of mouse SCMC core complex | 分子名称: | NACHT, LRR and PYD domains-containing protein 5, Oocyte-expressed protein homolog, ... | 著者 | Chi, P, Ou, G, Li, J, Han, Z, Deng, D. | 登録日 | 2022-10-24 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Structural basis of the subcortical maternal complex and its implications in reproductive disorders. Nat.Struct.Mol.Biol., 31, 2024
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8H95
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![BU of 8h95 by Molmil](/molmil-images/mine/8h95) | Structure of mouse SCMC bound with full-length FILIA | 分子名称: | NACHT, LRR and PYD domains-containing protein 5, Oocyte-expressed protein homolog, ... | 著者 | Chi, P, Ou, G, Han, Z, Li, L, Deng, D. | 登録日 | 2022-10-24 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Structural basis of the subcortical maternal complex and its implications in reproductive disorders. Nat.Struct.Mol.Biol., 31, 2024
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8HBB
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![BU of 8hbb by Molmil](/molmil-images/mine/8hbb) | |
8HB2
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![BU of 8hb2 by Molmil](/molmil-images/mine/8hb2) | |
8HAZ
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7UOH
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![BU of 7uoh by Molmil](/molmil-images/mine/7uoh) | PRMT5/MEP50 crystal structure with MTA and an achiral, class 1, non-atropisomeric inhibitor bound | 分子名称: | (2M)-2-[(4M)-4-{4-(aminomethyl)-1-oxo-8-[(2R)-oxolan-2-yl]-1,2-dihydrophthalazin-6-yl}-1-methyl-1H-pyrazol-5-yl]-1-benzothiophene-3-carbonitrile, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... | 著者 | Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. | 登録日 | 2022-04-12 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors. Bioorg.Med.Chem., 71, 2022
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7UYF
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![BU of 7uyf by Molmil](/molmil-images/mine/7uyf) | Human PRMT5:MEP50 structure with Fragment 4 and MTA Bound | 分子名称: | 4-methyl-1,5-naphthyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... | 著者 | Gunn, R.J, Lawson, J.D, Smith, C.R. | 登録日 | 2022-05-06 | 公開日 | 2022-10-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7UY1
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![BU of 7uy1 by Molmil](/molmil-images/mine/7uy1) | HUMAN PRMT5:MEP50 COMPLEX WITH MTA and Fragment 5 Bound | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-1,5-naphthyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... | 著者 | Gunn, R.J. | 登録日 | 2022-05-06 | 公開日 | 2022-10-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7X8J
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7X8K
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![BU of 7x8k by Molmil](/molmil-images/mine/7x8k) | Arabidopsis GDP-D-mannose pyrophosphorylase (VTC1) structure (product-bound) | 分子名称: | CITRATE ANION, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, Mannose-1-phosphate guanylyltransferase 1, ... | 著者 | Zhao, S, Zhang, C, Liu, L. | 登録日 | 2022-03-13 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal Structures of Arabidopsis thaliana GDP-D-Mannose Pyrophosphorylase VITAMIN C DEFECTIVE 1. Front Plant Sci, 13, 2022
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7UVF
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![BU of 7uvf by Molmil](/molmil-images/mine/7uvf) | Crystal structure of ZED8 Fab complex with CD8 alpha | 分子名称: | CHLORIDE ION, GLYCEROL, Immunoglobulin heavy chain, ... | 著者 | Yu, C, Davies, C, Koerber, J.T, Williams, S. | 登録日 | 2022-05-01 | 公開日 | 2022-10-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Preclinical development of ZED8, an 89 Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy. Eur J Nucl Med Mol Imaging, 50, 2023
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7UKR
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![BU of 7ukr by Molmil](/molmil-images/mine/7ukr) | Crystal Structure of SOS1 with MRTX0902, a Potent and Selective Inhibitor of the SOS1:KRAS Protein-Protein Interaction | 分子名称: | 2-methyl-3-[(1R)-1-{[4-methyl-7-(morpholin-4-yl)pyrido[3,4-d]pyridazin-1-yl]amino}ethyl]benzonitrile, Son of sevenless homolog 1 | 著者 | Gunn, R.J, Lawson, J.D, Ketcham, J.M, Marx, M.A. | 登録日 | 2022-04-01 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. J.Med.Chem., 65, 2022
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7UKS
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![BU of 7uks by Molmil](/molmil-images/mine/7uks) | Crystal structure of SOS1 with phthalazine inhibitor bound (compound 15) | 分子名称: | 4-methyl-N-{(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl}-7-(piperazin-1-yl)phthalazin-1-amine, Son of sevenless homolog 1 | 著者 | Gunn, R.J, Lawson, J.D, Ketcham, J.M, Marx, M.A. | 登録日 | 2022-04-01 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. J.Med.Chem., 65, 2022
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7V14
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![BU of 7v14 by Molmil](/molmil-images/mine/7v14) | Factor XIa in Complex with Compound 2h | 分子名称: | 5-[1-[(1~{R})-1-[5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-1-oxidanyl-pyridin-2-yl]-2-cyclopropyl-ethyl]pyrazol-4-yl]-1,3-thiazole, CITRIC ACID, Coagulation factor XIa light chain | 著者 | Shaffer, P.L, Cedervall, P, Milligan, C.M. | 登録日 | 2022-05-11 | 公開日 | 2022-08-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.697 Å) | 主引用文献 | Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions. J.Med.Chem., 65, 2022
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7V18
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![BU of 7v18 by Molmil](/molmil-images/mine/7v18) | Factor XIa in Complex with Compound 3f | 分子名称: | 2-[(1~{R})-3-[bis(fluoranyl)methoxy]-1-[4-(3-methyl-1,2,3-triazol-4-yl)pyrazol-1-yl]propyl]-5-[3-chloranyl-6-(4-chloranyl-1,2,3-triazol-1-yl)-2-fluoranyl-phenyl]-1-oxidanyl-pyridine, CITRIC ACID, Coagulation factor XIa light chain | 著者 | Shaffer, P.L, Milligan, C.M. | 登録日 | 2022-05-11 | 公開日 | 2022-08-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.732 Å) | 主引用文献 | Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions. J.Med.Chem., 65, 2022
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7V17
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![BU of 7v17 by Molmil](/molmil-images/mine/7v17) | Factor XIa in Complex with Compound 2k | 分子名称: | 5-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]-2-[(1~{R})-2-cyclopropyl-1-[4-(3-methylimidazol-4-yl)pyrazol-1-yl]ethyl]-1-oxidanyl-pyridine, CITRIC ACID, Coagulation factor XIa light chain | 著者 | Shaffer, P.L, Milligan, C.M, Cedervall, P. | 登録日 | 2022-05-11 | 公開日 | 2022-08-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.522 Å) | 主引用文献 | Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions. J.Med.Chem., 65, 2022
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