7WPS

Cryo-EM structure of VWF D'D3 dimer complexed with D1D2 at 4.3 angstron resolution (7 units)

This is a non-PDB format compatible entry.

Summary for 7WPS

• Entry DOI: 10.2210/pdb7wps/pdb
• EMDB information: 32690
• Descriptor: von Willebrand antigen 2, von Willebrand factor, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: blood, vwf, von willebrand factor, von willebrand disease, blood coagulation, blood clotting, multimer assembly, vwf assembly, d'd3 domain, d1d2 domain, d'd3 dimer, d1d2 dimer, vwf tube, repeating unit
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 28
• Total formula weight: 1910782.27

Authors

Zeng, J.W.,Shu, Z.M.,Zhou, A.W. (deposition date: 2022-01-24, release date: 2022-05-25, Last modification date: 2022-06-15)

• Primary citation: Zeng, J.,Shu, Z.,Liang, Q.,Zhang, J.,Wu, W.,Wang, X.,Zhou, A.; Structural basis of von Willebrand factor multimerization and tubular storage.; Blood, 139:3314-3324, 2022; PubMed: 35148377; DOI: 10.1182/blood.2021014729

Experimental method

ELECTRON MICROSCOPY (4.32 Å)