8UUG
| SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12303 | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-01 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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8UUH
| SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12199 | 分子名称: | 5-[2-(dimethylamino)ethoxy]-2-methyl-N-[(1R)-1-{(3M,5P)-3-(1-methyl-1H-pyrazol-4-yl)-5-[1-(propan-2-yl)-1H-pyrazol-4-yl]phenyl}ethyl]benzamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-01 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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7BST
| EcoR124I-Ocr in the Intermediate State | 分子名称: | Overcome classical restriction gp0.3, Type I restriction enzyme EcoR124II M protein, Type I restriction enzyme R Protein, ... | 著者 | Gao, Y, Gao, P. | 登録日 | 2020-03-31 | 公開日 | 2020-05-27 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.37 Å) | 主引用文献 | Structural insights into assembly, operation and inhibition of a type I restriction-modification system. Nat Microbiol, 5, 2020
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7BTR
| EcoR124I-ArdA in the Restriction-Alleviation State | 分子名称: | Antirestriction protein ArdA, Type I restriction enzyme EcoR124II M protein, Type I restriction enzyme R Protein, ... | 著者 | Gao, Y, Gao, P. | 登録日 | 2020-04-02 | 公開日 | 2020-05-27 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.54 Å) | 主引用文献 | Structural insights into assembly, operation and inhibition of a type I restriction-modification system. Nat Microbiol, 5, 2020
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8UUW
| SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12145 | 分子名称: | 5-[2-(dimethylamino)ethoxy]-2-methyl-N-{(1R)-1-[(3P,5M)-3-(1-methyl-1H-pyrazol-4-yl)-5-(1,3-thiazol-5-yl)phenyl]ethyl}benzamide, ACETATE ION, CHLORIDE ION, ... | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-02 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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7BX7
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8UUF
| SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun11941 | 分子名称: | ACETATE ION, CHLORIDE ION, N-{(1R)-1-[(3M,5P)-3,5-bis(1-methyl-1H-pyrazol-4-yl)phenyl]ethyl}-5-[2-(dimethylamino)ethoxy]-2-methylbenzamide, ... | 著者 | Ansari, A, Tan, B, Riuz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-01 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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8UUY
| SARS-CoV-2 papain-like protease (PLpro) complex with inhibitor Jun12129 | 分子名称: | ACETATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ansari, A, Tan, B, Ruiz, F.X, Arnold, E, Wang, J. | 登録日 | 2023-11-02 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science, 383, 2024
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8X5D
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8XOI
| Cryo-EM structure of GPR30-Gq complex structure in the presence of fulvestrant | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, H, Xu, P, Xu, H.E. | 登録日 | 2024-01-01 | 公開日 | 2024-04-10 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Res., 34, 2024
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8XOG
| Cryo-EM structure of apo-GPR30-Gq complex structure | 分子名称: | G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, H, Xu, P, Xu, H.E. | 登録日 | 2024-01-01 | 公開日 | 2024-04-10 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Res., 34, 2024
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7BR8
| Epstein-Barr virus, C5 penton vertex, CATC absent. | 分子名称: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | 著者 | Li, Z, Yu, X. | 登録日 | 2020-03-26 | 公開日 | 2020-09-30 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | CryoEM structure of the tegumented capsid of Epstein-Barr virus. Cell Res., 30, 2020
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8XOF
| Cryo-EM structure of Lys05 bound GPR30-Gq complex structure | 分子名称: | G protein subunit q, G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, H, Xu, P, Xu, H.E. | 登録日 | 2024-01-01 | 公開日 | 2024-04-10 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell Res., 34, 2024
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7BSI
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6A73
| Complex structure of CSN2 with IP6 | 分子名称: | COP9 signalosome complex subunit 2,Endolysin, INOSITOL HEXAKISPHOSPHATE, SULFATE ION | 著者 | Liu, L, Li, D, Rao, F, Wang, T. | 登録日 | 2018-07-02 | 公開日 | 2019-07-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.447 Å) | 主引用文献 | Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome. Proc.Natl.Acad.Sci.USA, 117, 2020
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7BTQ
| EcoR124I-DNA in the Restriction-Alleviation State | 分子名称: | DNA (64-MER), Type I restriction enzyme EcoR124II M protein, Type I restriction enzyme R Protein, ... | 著者 | Gao, Y, Gao, P. | 登録日 | 2020-04-02 | 公開日 | 2020-05-27 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.54 Å) | 主引用文献 | Structural insights into assembly, operation and inhibition of a type I restriction-modification system. Nat Microbiol, 5, 2020
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7BQT
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7BTO
| EcoR124I-ArdA in the Translocation State | 分子名称: | Antirestriction protein ArdA, Type I restriction enzyme EcoR124II M protein, Type I restriction enzyme R Protein, ... | 著者 | Gao, Y, Gao, P. | 登録日 | 2020-04-02 | 公開日 | 2020-05-27 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | 主引用文献 | Structural insights into assembly, operation and inhibition of a type I restriction-modification system. Nat Microbiol, 5, 2020
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7BQX
| Epstein-Barr virus, C5 portal vertex | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | 著者 | Li, Z, Yu, X. | 登録日 | 2020-03-25 | 公開日 | 2020-09-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | CryoEM structure of the tegumented capsid of Epstein-Barr virus. Cell Res., 30, 2020
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3QE7
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6M7I
| Crystal structure of KPC-2 with compound 3 | 分子名称: | 1-(2,4-dichlorophenyl)-4-(1H-tetrazol-5-yl)-1H-pyrazol-5-amine, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL | 著者 | Akhtar, A, Chen, Y. | 登録日 | 2018-08-20 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | 主引用文献 | Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. Acs Infect Dis., 5, 2019
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4HJE
| Crystal structure of p53 core domain in complex with DNA | 分子名称: | Cellular tumor antigen p53, DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), ... | 著者 | Chen, Y, Chen, L. | 登録日 | 2012-10-12 | 公開日 | 2013-07-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.907 Å) | 主引用文献 | Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion. Nucleic Acids Res., 41, 2013
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6KIK
| Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor tolrestat | 分子名称: | Oxidoreductase, aldo/keto reductase family, TOLRESTAT | 著者 | Zhang, C.Y, Liu, X.M, Wang, C, Tang, W.R. | 登録日 | 2019-07-18 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima. Febs Lett., 594, 2020
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6KIY
| Crystal structure of a thermostable aldo-keto reductase Tm1743 in complex with inhibitor Epalrestat | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, aldo/keto reductase family, ... | 著者 | Zhang, C.Y, Liu, X.M, Wang, C, Min, Z.Z, Xu, X.L. | 登録日 | 2019-07-20 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Tolrestat acts atypically as a competitive inhibitor of the thermostable aldo-keto reductase Tm1743 from Thermotoga maritima. Febs Lett., 594, 2020
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6MIA
| Crystal structure of CTX-M-14 with compound 6 | 分子名称: | 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one, Beta-lactamase | 著者 | Akhtar, A, Chen, Y. | 登録日 | 2018-09-19 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | 主引用文献 | Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. Acs Infect Dis., 5, 2019
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