8IY2
 
 | | Structure of Acb2 complexed with 3',3'-cGAMP and cAAA | | 分子名称: | 1,2-ETHANEDIOL, GUANOSINE-3'-MONOPHOSPHATE, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, ... | | 著者 | Cao, X.L, Xiao, Y, Feng, Y. | | 登録日 | 2023-04-03 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.
Mol.Cell, 84, 2024
|
|
8J8O
 | | Structure of Acb2 complexed with 2',3'-cGAMP | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, cGAMP, ... | | 著者 | Cao, X.L, Xiao, Y, Feng, Y. | | 登録日 | 2023-05-02 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides.
Mol.Cell, 84, 2024
|
|
5GZC
 | |
6JIV
 | | SspE crystal structure | | 分子名称: | SspE protein | | 著者 | Bing, Y.Z, Yang, H.G. | | 登録日 | 2019-02-23 | | 公開日 | 2020-03-25 | | 最終更新日 | 2020-07-08 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.
Nat Microbiol, 5, 2020
|
|
5GZD
 | |
7KEK
 | |
5GZF
 | |
8XAB
 | |
6QH9
 | | Crystal Structure of Human Kallikrein 6 in complex with GSK3239861A | | 分子名称: | (3~{R})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide, (3~{S})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide, GLYCEROL, ... | | 著者 | Thorpe, J.H. | | 登録日 | 2019-01-16 | | 公開日 | 2019-02-06 | | 最終更新日 | 2019-02-27 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
Bioorg. Med. Chem. Lett., 29, 2019
|
|
4ZMD
 | |
8GQ6
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex | | 分子名称: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | 著者 | Sun, L, Chen, Z, Hu, Y, Mao, Q. | | 登録日 | 2022-08-29 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.96 Å) | | 主引用文献 | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
|
|
6QFG
 | | Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK144 | | 分子名称: | 4-[(5-phenyl-1~{H}-imidazol-2-yl)methylamino]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide, GLYCEROL, Kallikrein-6 | | 著者 | Thorpe, J.H. | | 登録日 | 2019-01-10 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
Acta Crystallogr.,Sect.F, 75, 2019
|
|
6SKC
 | |
4ZNC
 | |
6QFS
 | | Chargeless variant of the Cellulose-binding domain from Cellulomonas fimi | | 分子名称: | 1,2-ETHANEDIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ... | | 著者 | Young, D.R, Hoejgaard, C, Messens, J, Winther, J.R. | | 登録日 | 2019-01-10 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Charge Interactions in a Highly Charge-depleted Protein
J.Am.Chem.Soc., 2021
|
|
6QHB
 | | Crystal Structure of Human Kallikrein 6 in complex with GSK578724A | | 分子名称: | GLYCEROL, Kallikrein-6, ~{N}-(4-carbamimidoylphenyl)-3-methoxy-2-oxidanyl-benzamide | | 著者 | Thorpe, J.H. | | 登録日 | 2019-01-16 | | 公開日 | 2019-02-06 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
Bioorg. Med. Chem. Lett., 29, 2019
|
|
6JUF
 | | SspB crystal structure | | 分子名称: | SspB protein | | 著者 | Liqiong, L, Yubing, Z. | | 登録日 | 2019-04-13 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.587 Å) | | 主引用文献 | SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.
Nat Microbiol, 5, 2020
|
|
8XV2
 | | Thiamine-bound human SLC19A3 | | 分子名称: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Soluble cytochrome b562,Thiamine transporter 2 | | 著者 | Dang, Y, Wang, G.P, Zhang, Z. | | 登録日 | 2024-01-14 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Substrate and drug recognition mechanisms of SLC19A3.
Cell Res., 34, 2024
|
|
8XV5
 | | Pyridoxamine-bound human SLC19A3 | | 分子名称: | 4-(AMINOMETHYL)-5-(HYDROXYMETHYL)-2-METHYLPYRIDIN-3-OL, Soluble cytochrome b562,Thiamine transporter 2 | | 著者 | Dang, Y, Wang, G.P, Zhang, Z. | | 登録日 | 2024-01-14 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Substrate and drug recognition mechanisms of SLC19A3.
Cell Res., 34, 2024
|
|
8XNG
 | |
8XV9
 | | Fedratinib-bound human SLC19A3 | | 分子名称: | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, Soluble cytochrome b562,Thiamine transporter 2 | | 著者 | Dang, Y, Wang, G.P, Zhang, Z. | | 登録日 | 2024-01-14 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Substrate and drug recognition mechanisms of SLC19A3.
Cell Res., 34, 2024
|
|
8K3S
 | | Structure of PKD2-F604P complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ... | | 著者 | Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y. | | 登録日 | 2023-07-16 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8XVZ
 | |
8XS4
 | |
8XVX
 | |
