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6SKC

Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK3448330A

Summary for 6SKC
Entry DOI10.2210/pdb6skc/pdb
DescriptorKallikrein-6, 4-[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]benzenecarboximidamide, BENZAMIDINE, ... (5 entities in total)
Functional Keywordsprotease, inhibitor, complex, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight49413.77
Authors
Thorpe, J.H. (deposition date: 2019-08-15, release date: 2019-09-25, Last modification date: 2024-01-24)
Primary citationWalker, A.L.,Denis, A.,Bingham, R.P.,Boulliot, A.,Edgar, E.V.,Ferrie, A.,Holmes, D.S.,Laroze, A.,Liddle, J.,Fouchet, M.H.,Moquette, A.,Nassau, P.,Pearce, A.C.,Polyakova, O.,Smith, K.J.,Thomas, P.,Thorpe, J.H.,Trottet, L.,Wang, Y.,Hovnanian, A.
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Bioorg.Med.Chem.Lett., 29:126675-126675, 2019
Cited by
PubMed: 31521475
DOI: 10.1016/j.bmcl.2019.126675
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.18 Å)
Structure validation

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