6SKC
Crystal Structure of Human Kallikrein 6 (I218Y) in complex with GSK3448330A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Kallikrein-6 | polymer | 223 | 24467.7 | 2 | UniProt (Q92876) Pfam (PF00089) | Homo sapiens (Human) | Neurosin,Protease M,SP59,Serine protease 18,Serine protease 9,Zyme |
| 2 | C (A) | 4-[(3~{S})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]benzenecarboximidamide | non-polymer | 266.1 | 1 | Chemie (LH8) | |||
| 3 | D (B) | BENZAMIDINE | non-polymer | 120.2 | 1 | Chemie (BEN) | |||
| 4 | E (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 245 (UniProt: Q92876)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | Arg 78 | engineered mutation |
| Gln 76 | Arg 80 | engineered mutation |
| Gln 132 | Asn 134 | engineered mutation |
| Tyr 218 | Ile 216 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48935.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 478.3 | |
| All* | Total formula weight | 49413.8 |
