6QH9

Crystal Structure of Human Kallikrein 6 in complex with GSK3239861A

Summary for 6QH9

Entry DOI	10.2210/pdb6qh9/pdb
Descriptor	Kallikrein-6, UNKNOWN ATOM OR ION, (3~{S})-~{N}-(4-carbamimidoylphenyl)-2-oxidanylidene-piperidine-3-carboxamide, ... (6 entities in total)
Functional Keywords	protease, inhibitor, complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	49968.65
Authors	Thorpe, J.H. (deposition date: 2019-01-16, release date: 2019-02-06, Last modification date: 2019-02-27)
Primary citation	White, G.V.,Edgar, E.V.,Holmes, D.S.,Lewell, X.Q.,Liddle, J.,Polyakova, O.,Smith, K.J.,Thorpe, J.H.,Walker, A.L.,Wang, Y.,Young, R.J.,Hovnanian, A. Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome. Bioorg. Med. Chem. Lett., 29:821-825, 2019 Cited by PubMed: 30691925 DOI: 10.1016/j.bmcl.2019.01.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation