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8JVE
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BU of 8jve by Molmil
Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer
分子名称: 1,2-ETHANEDIOL, 1-(3-methoxyphenyl)-1,2,3,4-tetrazole, Ubiquitin-conjugating enzyme E2 T
著者Anantharajan, J, Baburajendran, N.
登録日2023-06-28
公開日2023-11-29
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer.
Biochem.Biophys.Res.Commun., 689, 2023
8JVL
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BU of 8jvl by Molmil
Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer
分子名称: 1,2-ETHANEDIOL, 1-(4-methoxyphenyl)-1,2,3,4-tetrazole, Ubiquitin-conjugating enzyme E2 T
著者Anantharajan, J, Baburajendran, N.
登録日2023-06-28
公開日2023-11-29
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Identification and characterization of inhibitors covalently modifying catalytic cysteine of UBE2T and blocking ubiquitin transfer.
Biochem.Biophys.Res.Commun., 689, 2023
8JVD
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BU of 8jvd by Molmil
Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening
分子名称: 5-fluoranyl-1,3-benzoxazol-2-amine, Ubiquitin-conjugating enzyme E2 T
著者Anantharajan, J, Baburajendran, N.
登録日2023-06-28
公開日2024-02-28
実験手法X-RAY DIFFRACTION (1.696 Å)
主引用文献Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening.
Protein Sci., 33, 2024
8JUC
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BU of 8juc by Molmil
Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening
分子名称: 1,2-ETHANEDIOL, 7-methyl-2-(trifluoromethyl)-3~{H}-[1,2,4]triazolo[1,5-a]pyridin-5-one, Ubiquitin-conjugating enzyme E2 T
著者Anantharajan, J, Baburajendran, N.
登録日2023-06-26
公開日2024-02-28
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening.
Protein Sci., 33, 2024
5BOC
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BU of 5boc by Molmil
Crystal structure of topoisomerase ParE inhibitor
分子名称: 3-methyl-4-({3-[3-methyl-5-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)benzoic acid, DNA topoisomerase 4 subunit B
著者Tan, Y.W, Chen, G.Y, Hung, A.W, Hill, J.
登録日2015-05-27
公開日2015-06-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Application of Fragment-based Drug Discovery against DNA GyraseB
To be published
5BOD
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BU of 5bod by Molmil
Crystal structure of Streptococcus pneumonia ParE inhibitor
分子名称: (2R)-N-[3-(3,5-dimethylphenyl)-1H-pyrazol-5-yl]-1,4-dioxane-2-carboxamide, DNA topoisomerase 4 subunit B
著者Tan, Y.W, Chen, G, Hung, A.W, Hill, J.
登録日2015-05-27
公開日2015-06-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Application of Fragment-based Drug Discovery against DNA GyraseB
to be published
6JM9
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BU of 6jm9 by Molmil
cryo-EM structure of DOT1L bound to unmodified nucleosome
分子名称: DNA strand I, DNA strand J, Histone H2A, ...
著者Jang, S, Song, J.J.
登録日2019-03-07
公開日2019-05-15
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (7.3 Å)
主引用文献Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.
Genes Dev., 33, 2019
6JMA
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BU of 6jma by Molmil
cryo-EM structure of DOT1L bound to H2B ubiquitinated nucleosome
分子名称: DNA I&J, Histone H2A, Histone H2B 1.1, ...
著者Jang, S, Song, J.J.
登録日2019-03-07
公開日2019-05-15
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (6.8 Å)
主引用文献Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.
Genes Dev., 33, 2019
7X3X
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BU of 7x3x by Molmil
Cryo-EM structure of N1 nucleosome-RA
分子名称: DNA (146-MER), Histone H2A, Histone H2B 1.1, ...
著者Lifei, L, Kangjing, C, Chen, Z.
登録日2022-03-01
公開日2023-09-20
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024
7X3T
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BU of 7x3t by Molmil
Cryo-EM structure of ISW1a-dinucleosome
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (343-MER), ...
著者Lifei, L, Kangjing, C, Chen, Z.
登録日2022-03-01
公開日2023-09-20
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (5.4 Å)
主引用文献Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024
7X3V
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BU of 7x3v by Molmil
Cryo-EM structure of IOC3-N2 nucleosome
分子名称: DNA (146-MER), Histone H2A, Histone H2B 1.1, ...
著者Lifei, L, Kangjing, C, Chen, Z.
登録日2022-03-01
公開日2023-09-20
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024
7X3W
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BU of 7x3w by Molmil
Cryo-EM structure of ISW1-N1 nucleosome
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (146-MER), ...
著者Lifei, L, Kangjing, C, Chen, Z.
登録日2022-03-01
公開日2023-09-20
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure of the ISW1a complex bound to the dinucleosome.
Nat.Struct.Mol.Biol., 31, 2024

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件を2025-07-09に公開中

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