8GUB
| Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | 登録日 | 2022-09-11 | 公開日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8GUD
| Cryo-EM structure of cancer-specific PI3Kalpha mutant E545K in complex with BYL-719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | 登録日 | 2022-09-11 | 公開日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
8GUA
| Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | 登録日 | 2022-09-11 | 公開日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7V61
| ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3E8, ... | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | 登録日 | 2021-08-18 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker. Signal Transduct Target Ther, 6, 2021
|
|
7DRT
| Human Wntless in complex with Wnt3a | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhong, Q, Zhao, Y, Ye, F, Xiao, Z, Huang, G, Zhang, Y, Lu, P, Xu, W, Zhou, Q, Ma, D. | 登録日 | 2020-12-29 | 公開日 | 2021-07-14 | 最終更新日 | 2021-09-08 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Cryo-EM structure of human Wntless in complex with Wnt3a. Nat Commun, 12, 2021
|
|
7DUQ
| Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-01-11 | 公開日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
|
|
7DUR
| Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-01-11 | 公開日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
|
|
7EVM
| Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-05-21 | 公開日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
|
|
7CGE
| The overall structure of nucleotide free MlaFEDB complex | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, ... | 著者 | Chi, X.M, Fan, Q.X, Zhang, Y.Y, Liang, K, Zhou, Q, Li, Y.Y. | 登録日 | 2020-07-01 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Res., 30, 2020
|
|
7CGN
| The overall structure of the MlaFEDB complex in ATP-bound EQtall conformation (Mutation of E170Q on MlaF) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, ... | 著者 | Chi, X.M, Fan, Q.X, Zhang, Y.Y, Liang, K, Zhou, Q, Li, Y.Y. | 登録日 | 2020-07-01 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Res., 30, 2020
|
|
7CH0
| The overall structure of the MlaFEDB complex in ATP-bound EQclose conformation (Mutation of E170Q on MlaF) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, ... | 著者 | Chi, X.M, Fan, Q.X, Zhang, Y.Y, Liang, K, Zhou, Q, Li, Y.Y. | 登録日 | 2020-07-03 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Res., 30, 2020
|
|
7D0A
| Acinetobacter MlaFEDB complex in ADP-vanadate trapped Vclose conformation | 分子名称: | ABC transporter ATP-binding protein, ADENOSINE-5'-DIPHOSPHATE, Anti-sigma factor antagonist, ... | 著者 | Zhang, Y.Y, Fan, Q.X, Chi, X.M, Zhou, Q, Li, Y.Y. | 登録日 | 2020-09-09 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discov, 6, 2020
|
|
7D08
| Acinetobacter MlaFEDB complex in ATP-bound Vtrans1 conformation | 分子名称: | ABC transporter ATP-binding protein, ADENOSINE-5'-TRIPHOSPHATE, Anti-sigma factor antagonist, ... | 著者 | Zhang, Y.Y, Fan, Q.X, Chi, X.M, Zhou, Q, Li, Y.Y. | 登録日 | 2020-09-09 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discov, 6, 2020
|
|
7D09
| Acinetobacter MlaFEDB complex in ATP-bound Vtrans2 conformation | 分子名称: | ABC transporter ATP-binding protein, ADENOSINE-5'-TRIPHOSPHATE, Anti-sigma factor antagonist, ... | 著者 | Zhang, Y.Y, Fan, Q.X, Chi, X.M, Zhou, Q, Li, Y.Y. | 登録日 | 2020-09-09 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discov, 6, 2020
|
|
7D06
| Cryo EM structure of the nucleotide free Acinetobacter MlaFEDB complex | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, ABC transporter ATP-binding protein, Anti-sigma factor antagonist, ... | 著者 | Zhang, Y.Y, Fan, Q.X, Chi, X.M, Zhou, Q, Li, Y.Y. | 登録日 | 2020-09-09 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter. Cell Discov, 6, 2020
|
|
6JTO
| Crystal structure of HLA-C05 in complex with a tumor mut10m peptide | 分子名称: | 10-mer peptide, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | 著者 | Bai, P, Zhou, Q, Wei, P, Lei, Y. | 登録日 | 2019-04-11 | 公開日 | 2020-04-15 | 最終更新日 | 2021-05-19 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation. Sci China Life Sci, 2021
|
|
6KZE
| The crystal structue of PDE10A complexed with 4d | 分子名称: | 8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline, MAGNESIUM ION, ZINC ION, ... | 著者 | Yang, Y, Zhang, S, Zhou, Q, Huang, Y.-Y, Guo, L, Luo, H.-B. | 登録日 | 2019-09-24 | 公開日 | 2020-09-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.50003481 Å) | 主引用文献 | Novel Potent and Highly Selective Benzoimidazole-based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for the Treatment of Pulmonary Arterial Hypertension To Be Published
|
|
6M17
| The 2019-nCoV RBD/ACE2-B0AT1 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Xia, L, Guo, Y.Y, Zhou, Q. | 登録日 | 2020-02-24 | 公開日 | 2020-03-11 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science, 367, 2020
|
|
6M49
| cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. | 分子名称: | 25-HYDROXYCHOLESTEROL, Insulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein | 著者 | Yan, R, Cao, P, Song, W, Qian, H, Du, X, Coates, H.W, Zhao, X, Li, Y, Gao, S, Gong, X, Liu, X, Sui, J, Lei, J, Yang, H, Brown, A.J, Zhou, Q, Yan, C, Yan, N. | 登録日 | 2020-03-06 | 公開日 | 2021-01-20 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science, 371, 2021
|
|
6M18
| ACE2-B0AT1 complex | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Xia, L, Zhou, Q. | 登録日 | 2020-02-25 | 公開日 | 2020-03-11 | 最終更新日 | 2020-11-04 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science, 367, 2020
|
|
6M1D
| ACE2-B0AT1 complex, open conformation | 分子名称: | Angiotensin-converting enzyme 2, Sodium-dependent neutral amino acid transporter B(0)AT1 | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Xia, L, Zhou, Q. | 登録日 | 2020-02-25 | 公開日 | 2020-03-11 | 最終更新日 | 2020-04-08 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science, 367, 2020
|
|
7E21
| Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state with ATP-gamma-S | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, Y.Y, Zhang, Y.Y, Yan, R.H, Huang, B.D, Ye, F.F, Wu, L.S, Chi, X.M, Zhou, Q. | 登録日 | 2021-02-04 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nat Commun, 13, 2022
|
|
7E20
| Cryo EM structure of a K+-bound Na+,K+-ATPase in the E2 state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, Y.Y, Zhang, Y.Y, Yan, R.H, Huang, B.D, Ye, F.F, Wu, L.S, Chi, X.M, Zhou, Q. | 登録日 | 2021-02-04 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nat Commun, 13, 2022
|
|
7E1Z
| Cryo EM structure of a Na+-bound Na+,K+-ATPase in the E1 state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, Y.Y, Zhang, Y.Y, Yan, R.H, Huang, B.D, Ye, F.F, Wu, L.S, Chi, X.M, Zhou, Q. | 登録日 | 2021-02-04 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states. Nat Commun, 13, 2022
|
|
7EPZ
| Overall structure of Erastin-bound xCT-4F2hc complex | 分子名称: | 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATE, 2-[(1S)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Li, Y.N, Zhang, Y.Y, Chi, X.M, Zhou, Q. | 登録日 | 2021-04-28 | 公開日 | 2022-04-06 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis. Cell Res., 32, 2022
|
|