7EFR
| Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (T27W,N330Y) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | 著者 | Lu, G.W, Ye, F, Lin, X. | 登録日 | 2021-03-23 | 公開日 | 2021-11-24 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | 主引用文献 | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct Target Ther, 6, 2021
|
|
7EFP
| Structure of SARS-CoV-2 spike receptor-binding domain in complex with high affinity ACE2 mutant (S19W,N330Y) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein | 著者 | Lu, G.W, Ye, F, Lin, X. | 登録日 | 2021-03-22 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.698 Å) | 主引用文献 | S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis. Signal Transduct Target Ther, 6, 2021
|
|
4ZN2
| |
5ZKQ
| Crystal structure of the human platelet-activating factor receptor in complex with ABT-491 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, ... | 著者 | Cao, C, Zhao, Q, Zhang, X.C, Wu, B. | 登録日 | 2018-03-25 | 公開日 | 2018-06-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nat. Struct. Mol. Biol., 25, 2018
|
|
6WFU
| |
6WFT
| |
6XER
| Tubulin-RB3_SLD in complex with colchicine | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2020-06-13 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents. J.Med.Chem., 64, 2021
|
|
6XET
| Tubulin-RB3_SLD in complex with compound 60c | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2020-06-13 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents. J.Med.Chem., 64, 2021
|
|
6XES
| Tubulin-RB3_SLD in complex with compound 40a | 分子名称: | DIMETHYL SULFOXIDE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2020-06-13 | 公開日 | 2021-08-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents. J.Med.Chem., 64, 2021
|
|
8II0
| FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine | 分子名称: | 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | 著者 | Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J. | 登録日 | 2023-02-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity. Angew.Chem.Int.Ed.Engl., 63, 2024
|
|
8IHZ
| FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine | 分子名称: | 2-[[5-[1-[3-(4-chlorophenyl)propyl]-1,2,3-triazol-4-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... | 著者 | Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J. | 登録日 | 2023-02-24 | 公開日 | 2024-02-28 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity. Angew.Chem.Int.Ed.Engl., 63, 2024
|
|
5Z4Y
| |
7ECW
| The Csy-AcrIF14-dsDNA complex | 分子名称: | 54-MER DNA, AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, ... | 著者 | Zhang, L.X, Feng, Y. | 登録日 | 2021-03-13 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex. Nucleic Acids Res., 49, 2021
|
|
7ECV
| The Csy-AcrIF14 complex | 分子名称: | AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | 著者 | Zhang, L.X, Feng, Y. | 登録日 | 2021-03-13 | 公開日 | 2021-11-17 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex. Nucleic Acids Res., 49, 2021
|
|
7DU0
| |
5Z50
| Crystal structure of PaCysB regulatory domain | 分子名称: | Cys regulon transcriptional activator, GLYCEROL, SULFATE ION | 著者 | Yang, C, Liang, H, Gan, J. | 登録日 | 2018-01-15 | 公開日 | 2019-01-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Molecular insights into the master regulator CysB-mediated bacterial virulence in Pseudomonas aeruginosa. Mol.Microbiol., 111, 2019
|
|
5Z4Z
| |
8YN7
| Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo | 分子名称: | 4-(1H-imidazol-4-ylmethyl)pyridine, Antibody fragment scFv16, CHOLESTEROL, ... | 著者 | Zhang, X, Liu, G, Li, X, Gong, W. | 登録日 | 2024-03-10 | 公開日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural basis of ligand recognition and activation of the histamine receptor family Nat Commun, 15, 2024
|
|
8YN8
| Cryo-EM structure of histamine H3 receptor in complex with proxyfan and miniGo | 分子名称: | 5-(3-phenylmethoxypropyl)-1H-imidazole, Antibody fragment scFv16, CHOLESTEROL, ... | 著者 | Zhang, X, Liu, G, Li, X, Gong, W. | 登録日 | 2024-03-10 | 公開日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural basis of ligand recognition and activation of the histamine receptor family Nat Commun, 15, 2024
|
|
6OX7
| The complex of 1918 NS1-ED and the iSH2 domain of the human p85beta subunit of PI3K | 分子名称: | Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta | 著者 | Shen, Q, Zhao, B, Li, P, Cho, J.H. | 登録日 | 2019-05-13 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6P62
| HIV Env BG505 NFL TD+ in complex with antibody E70 fragment antigen binding | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env BG505 NFL TD+, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2019-05-31 | 公開日 | 2019-11-20 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability. Immunity, 51, 2019
|
|
6PEH
| |
7DPG
| Cryo-EM structure of Coxsackievirus B1 empty particle | 分子名称: | VP2, VP3, Virion protein 1 | 著者 | Li, S, Zhu, R, Xu, L, Cheng, T, Zheng, Q, Xia, N. | 登録日 | 2020-12-18 | 公開日 | 2021-05-05 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host Microbe, 29, 2021
|
|
7DQ7
| Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 5F5 | 分子名称: | 5F5 VH, 5F5 VL, Capsid protein VP4, ... | 著者 | Li, S, Zhu, R, Xu, L, Cheng, T, Zheng, Q. | 登録日 | 2020-12-22 | 公開日 | 2021-05-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host Microbe, 29, 2021
|
|
7DQ4
| Cryo-EM structure of CAR triggered Coxsackievirus B1 A-particle | 分子名称: | VP2, VP3, Virion protein 1 | 著者 | Li, S, Zhu, R, Xu, L, Cheng, T, Zheng, Q. | 登録日 | 2020-12-22 | 公開日 | 2021-05-05 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating. Cell Host Microbe, 29, 2021
|
|