4ZT7
 
 | | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-1,2,3,4-tetrahydroquinolin-4-yl]-N'-(5-fluoro-3H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1717) | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ... | | 著者 | Koh, C.-Y, Hol, W.G.J. | | 登録日 | 2015-05-14 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
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5W0I
 | | CREBBP Bromodomain in complex with Cpd8 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) | | 分子名称: | 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-[(3S)-oxolan-3-yl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein, DIMETHYL SULFOXIDE, ... | | 著者 | Murray, J.M. | | 登録日 | 2017-05-30 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
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4ZT5
 | | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine (Chem 1655) | | 分子名称: | (2S)-N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)-2-methylpropane-1,3-diamine, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Koh, C.-Y, Hol, W.G.J. | | 登録日 | 2015-05-14 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
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5W0Q
 | | CREBBP Bromodomain in complex with Cpd17 (N,2,7-trimethyl-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxamide) | | 分子名称: | (2R)-N,2,7-trimethyl-2,3-dihydro-4H-1,4-benzoxazine-4-carboxamide, CREB-binding protein, SULFATE ION | | 著者 | Murray, J.M. | | 登録日 | 2017-05-31 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
J. Med. Chem., 60, 2017
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4ZT4
 | | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitorN-(3,5-dichlorobenzyl)-2,2-difluoro-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1708) | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, METHIONINE, ... | | 著者 | Koh, C.-Y, Hol, W.G.J. | | 登録日 | 2015-05-14 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
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4ZT6
 | | Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-[(4R)-6,8-dichloro-3,4-dihydro-2H-chromen-4-yl]-N'-(5-fluoro-1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1709) | | 分子名称: | DIMETHYL SULFOXIDE, METHIONINE, Methionyl-tRNA synthetase, ... | | 著者 | Koh, C.-Y, Hol, W.G.J. | | 登録日 | 2015-05-14 | | 公開日 | 2016-05-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.
Acs Infect Dis., 2, 2016
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3STO
 | | Serpin from the trematode Schistosoma Haematobium | | 分子名称: | Serine protease inhibitor | | 著者 | Granzin, J, Weiergraeber, O.H, Lee, X, Blanton, R.E. | | 登録日 | 2011-07-11 | | 公開日 | 2012-05-30 | | 最終更新日 | 2013-01-23 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain.
Acta Crystallogr.,Sect.D, 68, 2012
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8EMT
 | | Cryo-EM analysis of the human aldehyde oxidase from liver | | 分子名称: | Aldehyde oxidase, DIOXOTHIOMOLYBDENUM(VI) ION, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Su, C, Lyu, M, Zhang, Z, Yu, E.W. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
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8EMR
 | | Cryo-EM structure of human liver glucosidase II | | 分子名称: | CALCIUM ION, Glucosidase 2 subunit beta, Neutral alpha-glucosidase AB, ... | | 著者 | Su, C, Lyu, M, Zhang, Z, Yu, E.W. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
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8EMS
 | | Cryo-EM structure of human liver glycogen phosphorylase | | 分子名称: | Glycogen phosphorylase, liver form, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Su, C, Lyu, M, Zhang, Z, Yu, E.W. | | 登録日 | 2022-09-28 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
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8SP0
 | | Symmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid | | 分子名称: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | | 著者 | Shen, Z.F, Yang, X.Y, Fu, T.M. | | 登録日 | 2023-05-01 | | 公開日 | 2023-08-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | | 主引用文献 | Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
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8SPO
 | | Tetramerized activation of MapSPARTA bound with NAD+ | | 分子名称: | MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Piwi domain-containing protein, ... | | 著者 | Shen, Z.F, Yang, X.Y, Fu, T.M. | | 登録日 | 2023-05-03 | | 公開日 | 2023-08-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
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8SQU
 | | Monomeric MapSPARTA bound with guide RNA and target DNA hybrid | | 分子名称: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | | 著者 | Shen, Z.F, Yang, X.Y, Fu, T.M. | | 登録日 | 2023-05-04 | | 公開日 | 2023-08-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
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8SP3
 | | Asymmetric dimer of MapSPARTA bound with gRNA/tDNA hybrid | | 分子名称: | MAGNESIUM ION, TIR-APAZ, guide RNA, ... | | 著者 | Shen, Z.F, Yang, X.Y, Fu, T.M. | | 登録日 | 2023-05-01 | | 公開日 | 2023-08-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Oligomerization-mediated activation of a short prokaryotic Argonaute.
Nature, 621, 2023
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8T1H
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8SNB
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6UJI
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6V3E
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6V39
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1PZV
 | | Crystal structures of two UBC (E2) enzymes of the ubiquitin-conjugating system in Caenorhabditis elegans | | 分子名称: | Probable ubiquitin-conjugating enzyme E2-19 kDa | | 著者 | Schormann, N, Lin, G, Li, S, Symersky, J, Qiu, S, Finley, J, Luo, D, Stanton, A, Carson, M, Luo, M, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2003-07-14 | | 公開日 | 2003-07-22 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Crystal structures of two UBC (E2) enzymes of the ubiquitin-conjugating system in Caenorhabditis elegans
To be Published
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6V3A
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6V3D
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6V3B
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1UEA
 | | MMP-3/TIMP-1 COMPLEX | | 分子名称: | CALCIUM ION, MATRIX METALLOPROTEINASE-3, TISSUE INHIBITOR OF METALLOPROTEINASE-1, ... | | 著者 | Bode, W, Maskos, K, Gomis-Rueth, F.-X, Nagase, H. | | 登録日 | 1997-06-06 | | 公開日 | 1998-10-14 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Nature, 389, 1997
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2H60
 | | Solution Structure of Human Brg1 Bromodomain | | 分子名称: | Probable global transcription activator SNF2L4 | | 著者 | Shen, W, Xu, C, Zhang, J, Wu, J, Shi, Y. | | 登録日 | 2006-05-30 | | 公開日 | 2007-02-13 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails
Biochemistry, 46, 2007
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