7YHG
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7YHH
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7YHF
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7YHI
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7W1S
| Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007 | 分子名称: | Nanobody Nb-007, Spike protein S1 | 著者 | Yang, J, Lin, S, Sun, H.L, Lu, G.W. | 登録日 | 2021-11-20 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding. Front Immunol, 13, 2022
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3J4F
| Structure of HIV-1 capsid protein by cryo-EM | 分子名称: | capsid protein | 著者 | Zhao, G, Perilla, J.R, Meng, X, Schulten, K, Zhang, P. | 登録日 | 2013-07-11 | 公開日 | 2013-07-24 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | 主引用文献 | Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics. Nature, 497, 2013
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3J3Y
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3J3Q
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8HSC
| Gi bound Orphan GPR20 complex with Fab046 in ligand-free state | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Lin, X, Jiang, S, Xu, F. | 登録日 | 2022-12-19 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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8HS3
| Gi bound orphan GPR20 in ligand-free state | 分子名称: | Ggama, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Lin, X, Jiang, S, Xu, F. | 登録日 | 2022-12-16 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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8HS2
| Orphan GPR20 in complex with Fab046 | 分子名称: | Light chain of Fab046, Soluble cytochrome b562,G-protein coupled receptor 20, heavy chain of Fab046 | 著者 | Lin, X, Jiang, S, Xu, F. | 登録日 | 2022-12-16 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | The activation mechanism and antibody binding mode for orphan GPR20. Cell Discov, 9, 2023
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4FZ4
| Crystal structure of HP0197-18kd | 分子名称: | CHLORIDE ION, NITRATE ION, Uncharacterized protein conserved in bacteria | 著者 | Yuan, Z, Yan, X. | 登録日 | 2012-07-06 | 公開日 | 2012-12-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Molecular mechanism by which surface antigen HP0197 mediates host cell attachment in the pathogenic bacteria Streptococcus suis J.Biol.Chem., 288, 2013
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4FZQ
| Crystal structure of HP0197-G5 | 分子名称: | Uncharacterized protein conserved in bacteria | 著者 | Yuan, Z, Yan, X. | 登録日 | 2012-07-07 | 公開日 | 2012-12-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular mechanism by which surface antigen HP0197 mediates host cell attachment in the pathogenic bacteria Streptococcus suis J.Biol.Chem., 288, 2013
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7DK0
| Crystal structure of SARS-CoV-2 Spike RBD in complex with MW05 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MW05 heavy chain, MW05 light chain, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | 登録日 | 2020-11-22 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.199 Å) | 主引用文献 | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires Fc gamma RIIB and virus-antibody complex with bivalent interaction. Commun Biol, 5, 2022
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7DJZ
| Crystal structure of SARS-CoV-2 Spike RBD in complex with MW01 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, MW01 heavy chain, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | 登録日 | 2020-11-22 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.397 Å) | 主引用文献 | Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires Fc gamma RIIB and virus-antibody complex with bivalent interaction. Commun Biol, 5, 2022
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4H2A
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7X2K
| Crystal structure of nanobody Nb70 with antibody 1F11 fab and SARS-CoV-2 RBD | 分子名称: | 1F11-H, 1F11-L, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X. | 登録日 | 2022-02-25 | 公開日 | 2022-12-21 | 最終更新日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses. Nat Commun, 13, 2022
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7X2J
| Crystal structure of nanobody Nb70 with SARS-CoV RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nb70, Spike protein S1 | 著者 | Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X. | 登録日 | 2022-02-25 | 公開日 | 2022-12-21 | 最終更新日 | 2023-06-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses. Nat Commun, 13, 2022
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7X2M
| Crystal structure of nanobody 1-2C7 with SARS-CoV-2 RBD | 分子名称: | 1-2C7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1 | 著者 | Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X. | 登録日 | 2022-02-25 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses. Nat Commun, 13, 2022
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7X2L
| Crystal structure of nanobody 3-2A2-4 with SARS-CoV-2 RBD | 分子名称: | Nanobody 3-2A2-4, Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X. | 登録日 | 2022-02-25 | 公開日 | 2022-12-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses. Nat Commun, 13, 2022
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7Y1F
| Cryo-EM structure of human k-opioid receptor-Gi complex | 分子名称: | Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Chen, B.O, Xu, F.E. | 登録日 | 2022-06-08 | 公開日 | 2023-05-24 | 最終更新日 | 2023-06-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structure of human kappa-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A. Protein Cell, 14, 2023
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7DPM
| Crystal structure of SARS-CoV-2 Spike RBD in complex with MW06 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M. | 登録日 | 2020-12-20 | 公開日 | 2021-02-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.304 Å) | 主引用文献 | Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV. Mabs, 13, 2021
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4NAH
| Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT) | 分子名称: | 2-[(2-{(1S,2S)-2-[(3,4-dichlorobenzyl)carbamoyl]cyclohexyl}-6-ethylpyrimidin-4-yl)sulfanyl]-1H-imidazole-5-carboxylic acid, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Phosphopantetheine adenylyltransferase | 著者 | Lahiri, S.D. | 登録日 | 2013-10-22 | 公開日 | 2014-03-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy. Antimicrob.Agents Chemother., 57, 2013
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7VAA
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7VA8
| Crystal structure of MiCGT | 分子名称: | UDP-glycosyltransferase 13, URIDINE-5'-DIPHOSPHATE-GLUCOSE | 著者 | Zhong, L, Zhang, Z.M. | 登録日 | 2021-08-27 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.85003233 Å) | 主引用文献 | Directed Evolution of a Plant Glycosyltransferase for Chemo- and Regioselective Glycosylation of Pharmaceutically Significant Flavonoids Acs Catalysis, 11, 2021
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