4NAH
Inhibitors of 4-Phosphopanthetheine Adenylyltransferase (PPAT)
Summary for 4NAH
Entry DOI | 10.2210/pdb4nah/pdb |
Related | 4NAT 4NAU |
Descriptor | Phosphopantetheine adenylyltransferase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, 2-[(2-{(1S,2S)-2-[(3,4-dichlorobenzyl)carbamoyl]cyclohexyl}-6-ethylpyrimidin-4-yl)sulfanyl]-1H-imidazole-5-carboxylic acid, ... (4 entities in total) |
Functional Keywords | phosphopanthetheine adenylyltransferase, phosphopanthetheine, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm (By similarity): P63820 |
Total number of polymer chains | 6 |
Total formula weight | 116729.17 |
Authors | Lahiri, S.D. (deposition date: 2013-10-22, release date: 2014-03-12, Last modification date: 2024-02-28) |
Primary citation | de Jonge, B.L.,Walkup, G.K.,Lahiri, S.D.,Huynh, H.,Neckermann, G.,Utley, L.,Nash, T.J.,Brock, J.,San Martin, M.,Kutschke, A.,Johnstone, M.,Laganas, V.,Hajec, L.,Gu, R.F.,Ni, H.,Chen, B.,Hutchings, K.,Holt, E.,McKinney, D.,Gao, N.,Livchak, S.,Thresher, J. Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy. Antimicrob.Agents Chemother., 57:6005-6015, 2013 Cited by PubMed: 24041904DOI: 10.1128/AAC.01661-13 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.38 Å) |
Structure validation
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