7E4Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7e4q by Molmil](/molmil-images/mine/7e4q) | Crystal structure of tubulin in complex with L-DM1-SMe | 分子名称: | (1S,2R,3R,5R,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-(methyldisulfanyl)propanoyl]amino}propanoate (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Li, W. | 登録日 | 2021-02-14 | 公開日 | 2021-07-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids. Biochem.Biophys.Res.Commun., 566, 2021
|
|
7D0E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7d0e by Molmil](/molmil-images/mine/7d0e) | Crystal structure of FIP200 Claw/p-CCPG1 FIR2 | 分子名称: | 3-(2-hydroxyethyloxy)-2-[2-(2-hydroxyethyloxy)ethoxymethyl]-2-(2-hydroxyethyloxymethyl)propan-1-ol, Cell cycle progression protein 1 FIR2, DI(HYDROXYETHYL)ETHER, ... | 著者 | Zhou, Z.X, Pan, L.F. | 登録日 | 2020-09-09 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
|
|
7CZG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7czg by Molmil](/molmil-images/mine/7czg) | Crystal structure of FIP200 Claw domain apo form | 分子名称: | DI(HYDROXYETHYL)ETHER, RB1-inducible coiled-coil protein 1 | 著者 | Zhou, Z.X, Pan, L.F. | 登録日 | 2020-09-08 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation. Nat Commun, 12, 2021
|
|
6LRB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lrb by Molmil](/molmil-images/mine/6lrb) | |
7CZM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7czm by Molmil](/molmil-images/mine/7czm) | |
3QK5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3qk5 by Molmil](/molmil-images/mine/3qk5) | Crystal structure of fatty acid amide hydrolase with small molecule inhibitor | 分子名称: | (3-{(3R)-1-[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]piperidin-3-yl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetonitrile, 1,2-ETHANEDIOL, Fatty-acid amide hydrolase 1, ... | 著者 | Min, X, Walker, N.P.C, Wang, Z. | 登録日 | 2011-01-31 | 公開日 | 2011-04-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3H0A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3h0a by Molmil](/molmil-images/mine/3h0a) | Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist | 分子名称: | 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid, Nuclear receptor coactivator 1, Co-activator Peptide, ... | 著者 | Wang, Z, Sudom, A, Walker, N.P. | 登録日 | 2009-04-08 | 公開日 | 2009-06-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. Bioorg.Med.Chem.Lett., 19, 2009
|
|
7E4R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7e4r by Molmil](/molmil-images/mine/7e4r) | Crystal structure of tubulin in complex with D-DM1-SMe | 分子名称: | (10E,12E)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-methyl-N-(3-(methylsulfinothioyl)propanoyl)-D-alaninate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, Y, Li, W. | 登録日 | 2021-02-15 | 公開日 | 2021-07-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.597 Å) | 主引用文献 | C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids. Biochem.Biophys.Res.Commun., 566, 2021
|
|
6AN6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6an6 by Molmil](/molmil-images/mine/6an6) | Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-72 | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-{2-[{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}(phosphonomethyl)amino]ethyl}-5'-thioadenosine | 著者 | Shaw, G.X, Shi, G, Ji, X. | 登録日 | 2017-08-12 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Bisubstrate analogue inhibitors of HPPK: Transition state mimetics to be published
|
|
7NHG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nhg by Molmil](/molmil-images/mine/7nhg) | |
7NIA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nia by Molmil](/molmil-images/mine/7nia) | |
7NI9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ni9 by Molmil](/molmil-images/mine/7ni9) | |
7NHV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nhv by Molmil](/molmil-images/mine/7nhv) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ016 | 分子名称: | (R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | 登録日 | 2021-02-11 | 公開日 | 2021-10-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
|
|
7NHH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nhh by Molmil](/molmil-images/mine/7nhh) | |
7NI7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ni7 by Molmil](/molmil-images/mine/7ni7) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ031 | 分子名称: | (R)-4-((4,4-dimethylpiperidin-1-yl)methyl)-2-hydroxy-N-((3-hydroxy-1-(6-((3-(methylcarbamoyl)benzyl)amino)pyrimidin-4-yl)piperidin-3-yl)methyl)benzamide, ACETATE ION, MAGNESIUM ION, ... | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | 登録日 | 2021-02-11 | 公開日 | 2021-10-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
|
|
7NID
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nid by Molmil](/molmil-images/mine/7nid) | Crystal structure of the human METTL3-METTL14 complex with compound UOZ078 | 分子名称: | (R)-1-(6-(benzylamino)pyrimidin-4-yl)-3-(((6-((4,4-dimethylpiperidin-1-yl)methyl)naphthalen-1-yl)amino)methyl)piperidin-3-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | 著者 | Bedi, R.K, Huang, D, Caflisch, A. | 登録日 | 2021-02-11 | 公開日 | 2021-10-20 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023
|
|
7NHJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nhj by Molmil](/molmil-images/mine/7nhj) | |
7NI8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ni8 by Molmil](/molmil-images/mine/7ni8) | |
6LSA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lsa by Molmil](/molmil-images/mine/6lsa) | Complex structure of bovine herpesvirus 1 glycoprotein D and bovine nectin-1 IgV | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein D, ... | 著者 | Yue, D, Chen, Z.J, Yang, F.L, Ye, F, Lin, S, Cheng, Y.W, Wang, J.C, Chen, Z.M, Lin, X, Yang, J, Chen, H, Zhang, Z.L, You, Y, Sun, H.L, Wen, A, Wang, L.L, Zheng, Y, Cao, Y, Li, Y.H, Lu, G.W. | 登録日 | 2020-01-17 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.204 Å) | 主引用文献 | Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor. Sci Adv, 6, 2020
|
|
4ER6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4er6 by Molmil](/molmil-images/mine/4er6) | Crystal structure of human DOT1L in complex with inhibitor SGC0946 | 分子名称: | 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, BROMIDE ION, Histone-lysine N-methyltransferase, ... | 著者 | Wernimont, A.K, Tempel, W, Yu, W, Scopton, A, Li, Y, Nguyen, K.T, Vedadi, M, Bradner, J.E, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2012-04-19 | 公開日 | 2012-05-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun, 3, 2012
|
|
7CZP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7czp by Molmil](/molmil-images/mine/7czp) | S protein of SARS-CoV-2 in complex bound with P2B-1A1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c181_light_IGLV2-14_IGLJ3,IGL@ protein, ... | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | 登録日 | 2020-09-09 | 公開日 | 2021-03-10 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
|
|
7CZQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7czq by Molmil](/molmil-images/mine/7czq) | S protein of SARS-CoV-2 in complex bound with P2B-1A10 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c642_heavy_IGHV3-53_IGHD1-26_IGHJ6,Chain H of P2B-1A10,Immunoglobulin gamma-1 heavy chain, ... | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | 登録日 | 2020-09-09 | 公開日 | 2021-03-10 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
|
|
7CZR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7czr by Molmil](/molmil-images/mine/7czr) | S protein of SARS-CoV-2 in complex bound with P5A-1B8_2B | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c542_heavy_IGHV3-53_IGHD3-10_IGHJ6,IGH@ protein, ... | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | 登録日 | 2020-09-09 | 公開日 | 2021-03-10 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
|
|
7CZT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7czt by Molmil](/molmil-images/mine/7czt) | S protein of SARS-CoV-2 in complex bound with P5A-2G9 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c689_light_IGLV5-37_IGLJ3,IGL@ protein, ... | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | 登録日 | 2020-09-09 | 公開日 | 2021-03-10 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
|
|
7CZS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7czs by Molmil](/molmil-images/mine/7czs) | S protein of SARS-CoV-2 in complex bound with P5A-1B8_3B | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c542_heavy_IGHV3-53_IGHD3-10_IGHJ6,IGH@ protein, ... | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | 登録日 | 2020-09-09 | 公開日 | 2021-03-10 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
|
|