6SJA
 
 | | Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | | 著者 | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | | 登録日 | 2019-08-13 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Deciphering de molecular and structural interaction between IRF3 and HPV16 E6
To be published
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8IMS
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6SMV
 | | Structure of HPV49 E6 protein in complex with MAML1 LxxLL motif | | 分子名称: | DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein,Protein E6,Mastermind-like protein 1, ZINC ION, ... | | 著者 | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Kostmann, C, Mitschler, A, Podjarny, A, Trave, G. | | 登録日 | 2019-08-22 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Cellular target recognition by HPV18 and HPV49 oncoproteins
To be published
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5GO3
 | | Crystal structure of a di-nucleotide cyclase Vibrio mutant | | 分子名称: | Cyclic GMP-AMP synthase | | 著者 | Ming, Z.H, Wang, W, Xie, Y.C, Chen, Y.C, Yan, L.M, Lou, Z.Y. | | 登録日 | 2016-07-26 | | 公開日 | 2016-11-02 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of a di-nucleotide cyclase Vibrio mutant
To Be Published
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8IJS
 | | anti-VEGF nanobody mutant | | 分子名称: | ZINC ION, anti-VEGF nanobody | | 著者 | Qian, F, Zhu, S.Q. | | 登録日 | 2023-02-28 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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8IIU
 | | anti-VEGF nanobody | | 分子名称: | SULFATE ION, anti-VEGF nanobody | | 著者 | Qian, F, Zhu, S.Q. | | 登録日 | 2023-02-24 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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8IJZ
 | | anti-VEGF mutant | | 分子名称: | anti-VEGF nanobody | | 著者 | Qian, F, Zhu, S.Q. | | 登録日 | 2023-02-28 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | | 主引用文献 | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration.
Bioeng Transl Med, 8, 2023
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4GQG
 | | Crystal structure of AKR1B10 complexed with NADP+ | | 分子名称: | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zhang, L, Zheng, X, Chen, S, Zhai, J, Hu, X. | | 登録日 | 2012-08-23 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587, 2013
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8WA3
 | | Cryo-EM structure of peptide free and Gs-coupled GIPR | | 分子名称: | Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... | | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | 登録日 | 2023-09-06 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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8WG7
 | | Cryo-EM structures of peptide free and Gs-coupled GLP-1R | | 分子名称: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | 登録日 | 2023-09-20 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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8WG8
 | | Cryo-EM structures of peptide free and Gs-coupled GCGR | | 分子名称: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | | 登録日 | 2023-09-20 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
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5H3R
 | | Crystal Structure of mutant MarR C80S from E.coli complexed with operator DNA | | 分子名称: | DNA (5'-D(*CP*AP*TP*AP*CP*TP*TP*GP*CP*CP*TP*GP*GP*GP*CP*AP*AP*TP*AP*TP*T)-3'), DNA (5'-D(*GP*AP*AP*TP*AP*TP*TP*GP*CP*CP*CP*AP*GP*GP*CP*AP*AP*GP*TP*AP*T)-3'), Multiple antibiotic resistance protein MarR | | 著者 | Zhu, R, Lou, H, Hao, Z. | | 登録日 | 2016-10-26 | | 公開日 | 2017-08-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator.
J. Biol. Inorg. Chem., 22, 2017
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6J75
 | | Structure of 3,6-anhydro-L-galactose Dehydrogenase | | 分子名称: | Aldehyde dehydrogenase A | | 著者 | Li, P.Y, Wang, Y, Chen, X.L, Zhang, Y.Z. | | 登録日 | 2019-01-17 | | 公開日 | 2020-01-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.695 Å) | | 主引用文献 | 3,6-Anhydro-L-Galactose Dehydrogenase VvAHGD is a Member of a New Aldehyde Dehydrogenase Family and Catalyzes by a Novel Mechanism with Conformational Switch of Two Catalytic Residues Cysteine 282 and Glutamate 248.
J.Mol.Biol., 432, 2020
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8WI0
 | | wt-hMRP5 inward-open | | 分子名称: | ATP-binding cassette sub-family C member 5 | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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8JBR
 | | Structure of McyA2-CAPCP | | 分子名称: | 4'-PHOSPHOPANTETHEINE, ADENOSINE-5'-TRIPHOSPHATE, McyA protein | | 著者 | Peng, Y.J. | | 登録日 | 2023-05-09 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains.
Structure, 32, 2024
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3J3W
 | | Atomic model of the immature 50S subunit from Bacillus subtilis (state II-a) | | 分子名称: | 50S ribosomal protein L1, 50S ribosomal protein L11, 50S ribosomal protein L13, ... | | 著者 | Li, N, Guo, Q, Zhang, Y, Yuan, Y, Ma, C, Lei, J, Gao, N. | | 登録日 | 2013-04-28 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (10.7 Å) | | 主引用文献 | Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit
Nucleic Acids Res., 41, 2013
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8WI5
 | | M5PI-bound hMRP5 | | 分子名称: | ATP-binding cassette sub-family C member 5 | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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8WI2
 | | RD-hMRP5-inward open | | 分子名称: | ATP-binding cassette sub-family C member 5, CYS-GLN-ASP-ALA-LEU-GLU-THR-ALA-ALA-ARG-ALA-GLU-GLY-LEU-SER-LEU-ASP-ALA-SER | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4.06 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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7WWM
 | | S protein of Delta variant in complex with ZWC6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | | 登録日 | 2022-02-13 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination.
Signal Transduct Target Ther, 7, 2022
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8WI3
 | | ND-hMRP5-inward open | | 分子名称: | ATP-binding cassette sub-family C member 5 | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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8WI4
 | | m6-hMRP5 inward open | | 分子名称: | ATP-binding cassette sub-family C member 5 | | 著者 | Liu, Z.M, Huang, Y. | | 登録日 | 2023-09-24 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5.
Nat Commun, 15, 2024
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7WWL
 | | S protein of Delta variant in complex with ZWD12 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | | 登録日 | 2022-02-13 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination.
Signal Transduct Target Ther, 7, 2022
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6CDX
 | | High-resolution crystal structure of fluoropropylated cystine knot, binding to alpha-5 beta-6 integrin | | 分子名称: | cystine knot (fluoropropylated) | | 著者 | Kimura, R, Nix, J, Bongura, C, Chakraborti, S, Gambhir, S, Filipp, F.V. | | 登録日 | 2018-02-09 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Evaluation of integrin alpha v beta6cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis.
Nat Commun, 10, 2019
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6GG4
 | | Crystal structure of M2 PYK in complex with Phenyalanine. | | 分子名称: | PHENYLALANINE, PHOSPHATE ION, POTASSIUM ION, ... | | 著者 | McNae, I.W, Yuan, M, Walkinshaw, M.D. | | 登録日 | 2018-05-02 | | 公開日 | 2018-05-23 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
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6SIV
 | | Structure of HPV16 E6 oncoprotein in complex with mutant IRF3 LxxLL motif | | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... | | 著者 | Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. | | 登録日 | 2019-08-12 | | 公開日 | 2019-08-21 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | | 主引用文献 | Deciphering the molecular and structural interaction between IRF3 and HPV16 E6
To be published
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