7U1V
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![BU of 7u1v by Molmil](/molmil-images/mine/7u1v) | Structure of SPAC806.04c protein from fission yeast covalently bound to BeF3 | 分子名称: | Damage-control phosphatase SPAC806.04c, NICKEL (II) ION, PHOSPHATE ION, ... | 著者 | Jacewicz, A, Sanchez, A.M, Shuman, S. | 登録日 | 2022-02-22 | 公開日 | 2022-06-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. J.Biol.Chem., 298, 2022
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7U1X
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7TOO
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![BU of 7too by Molmil](/molmil-images/mine/7too) | Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | 分子名称: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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6VZS
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![BU of 6vzs by Molmil](/molmil-images/mine/6vzs) | Engineered TTLL6 mutant bound to gamma-elongation analog | 分子名称: | (2~{S})-2-[[[(3~{R})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | 著者 | Mahalingan, K.K, Keenen, E.K, Strickland, M, Li, Y, Liu, Y, Ball, H.L, Tanner, M.E, Tjandra, N, Roll-Mecak, A. | 登録日 | 2020-02-28 | 公開日 | 2020-08-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Nat.Struct.Mol.Biol., 27, 2020
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6W0H
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![BU of 6w0h by Molmil](/molmil-images/mine/6w0h) | Closed-gate KcsA soaked in 5mM KCl/5mM BaCl2 | 分子名称: | Fab Heavy Chain, Fab Light Chain, POTASSIUM ION, ... | 著者 | Rohaim, A, Gong, L, Li, J. | 登録日 | 2020-02-29 | 公開日 | 2020-07-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
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6VI5
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![BU of 6vi5 by Molmil](/molmil-images/mine/6vi5) | Observing a ring-cleaving dioxygenase in action through a crystalline lens - a resting state structure | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, CHLORIDE ION, ... | 著者 | Wang, Y, Liu, F, Yang, Y, Liu, A. | 登録日 | 2020-01-12 | 公開日 | 2020-07-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.604 Å) | 主引用文献 | Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens. Proc.Natl.Acad.Sci.USA, 117, 2020
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2PWP
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![BU of 2pwp by Molmil](/molmil-images/mine/2pwp) | Crystal structure of spermidine synthase from Plasmodium falciparum in complex with spermidine | 分子名称: | GLYCEROL, SPERMIDINE, SULFATE ION, ... | 著者 | Qiu, W, Dong, A, Ren, H, Wu, H, Zhao, Y, Schapira, M, Wasney, G, Vedadi, M, Lew, J, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Plotnikov, A.N, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC) | 登録日 | 2007-05-11 | 公開日 | 2007-05-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of spermidine synthase from Plasmodium falciparum in complex with spermidine. To be Published
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6VJ7
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![BU of 6vj7 by Molmil](/molmil-images/mine/6vj7) | Crystal structure of red kidney bean purple acid phosphatase in complex with adenosine 5'-(beta,gamma imido)triphosphate | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Feder, D, Schenk, G, Guddat, L.W, McGeary, R.P, Mitic, N, Furtado, A, Schulz, B.L, Henry, R.J, Schmidt, S. | 登録日 | 2020-01-15 | 公開日 | 2020-04-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural elements that modulate the substrate specificity of plant purple acid phosphatases: Avenues for improved phosphorus acquisition in crops. Plant Sci., 294, 2020
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6VLE
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![BU of 6vle by Molmil](/molmil-images/mine/6vle) | Crystal structure of human alpha 1,6-fucosyltransferase, FUT8 in its Apo-form | 分子名称: | Alpha-(1,6)-fucosyltransferase, SULFATE ION | 著者 | Jarva, M.A, Dramicanin, M, Lingford, J.P, Mao, R, John, A, Goddard-Borger, E.D. | 登録日 | 2020-01-23 | 公開日 | 2020-02-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structural basis of substrate recognition and catalysis by fucosyltransferase 8. J.Biol.Chem., 295, 2020
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5NMX
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![BU of 5nmx by Molmil](/molmil-images/mine/5nmx) | Crystal Structure of the pyrrolizidine alkaloid N-oxygenase from Zonocerus variegatus in complex with FAD and NADP+ | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Flavin-containing monooxygenase, MAGNESIUM ION, ... | 著者 | Scheidig, A, Kubitza, C, Faust, A, Ober, D. | 登録日 | 2017-04-07 | 公開日 | 2018-03-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus. Acta Crystallogr D Struct Biol, 74, 2018
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7TYG
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6VUU
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![BU of 6vuu by Molmil](/molmil-images/mine/6vuu) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1347 | 分子名称: | (7S)-7-methyl-2-{[3-(piperidin-1-yl)propyl]sulfanyl}-7,8-dihydro[1]benzothieno[2,3-d]pyrimidin-4-amine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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6VV1
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![BU of 6vv1 by Molmil](/molmil-images/mine/6vv1) | Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT384 | 分子名称: | 2-[(4-amino-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(piperidin-1-yl)ethyl]acetamide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2020-02-16 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
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7TXH
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![BU of 7txh by Molmil](/molmil-images/mine/7txh) | Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca | 分子名称: | GLYCEROL, Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, ... | 著者 | Hauseman, Z.J, Viscomi, J, Dhembi, A, Clark, K, King, D.A, Fodor, M. | 登録日 | 2022-02-09 | 公開日 | 2022-06-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure of the MRAS-SHOC2-PP1C phosphatase complex. Nature, 609, 2022
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6W2Z
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![BU of 6w2z by Molmil](/molmil-images/mine/6w2z) | Crystal Structure of the Beta Lactamase Class A PenP from Bacillus subtilis in the Complex with the Non-beta- lactam Beta-lactamase Inhibitor Avibactam | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, Beta-lactamase, ... | 著者 | Kim, Y, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-03-08 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structure of the Beta Lactamase Class A PenP from Bacillus subtilis in the Complex with the Non-beta- lactam Beta-lactamase Inhibitor Avibactam To Be Published
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2OME
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![BU of 2ome by Molmil](/molmil-images/mine/2ome) | Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H) | 分子名称: | C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Pilka, E.S, Guo, K, Rojkova, A, Debreczeni, J.E, Kavanagh, K.L, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2007-01-22 | 公開日 | 2007-02-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H) To be Published
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3Q4U
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![BU of 3q4u by Molmil](/molmil-images/mine/3q4u) | Crystal structure of the ACVR1 kinase domain in complex with LDN-193189 | 分子名称: | 1,2-ETHANEDIOL, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, Activin receptor type-1, ... | 著者 | Chaikuad, A, Sanvitale, C, Cooper, C.D.O, Mahajan, P, Daga, N, Petrie, K, Alfano, I, Gileadi, O, Fedorov, O, Allerston, C.K, Krojer, T, Vollmar, M, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) | 登録日 | 2010-12-24 | 公開日 | 2011-02-09 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | A new class of small molecule inhibitor of BMP signaling. Plos One, 8, 2013
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6W3H
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![BU of 6w3h by Molmil](/molmil-images/mine/6w3h) | Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATV Fc, Transferrin receptor protein 1,Transferrin receptor protein 1 | 著者 | Srivastava, A, Kariolis, M, Wells, R. | 登録日 | 2020-03-09 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.38 Å) | 主引用文献 | Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys. Sci Transl Med, 12, 2020
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6W3O
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![BU of 6w3o by Molmil](/molmil-images/mine/6w3o) | Crystal structure of ligand-binding domain of Campylobacter jejuni chemoreceptor Tlp3 in complex with 4-methylisoleucine | 分子名称: | 4-methylisoleucine, CHLORIDE ION, Methyl-accepting chemotaxis protein, ... | 著者 | Khan, M.F, Machuca, M.A, Rahman, M.M, Roujeinikova, A. | 登録日 | 2020-03-09 | 公開日 | 2020-05-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Structure-Activity Relationship Study Reveals the Molecular Basis for Specific Sensing of Hydrophobic Amino Acids by theCampylobacter jejuniChemoreceptor Tlp3. Biomolecules, 10, 2020
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6W0C
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![BU of 6w0c by Molmil](/molmil-images/mine/6w0c) | Open-gate KcsA soaked in 4 mM BaCl2 | 分子名称: | BARIUM ION, Fab Heavy Chain, Fab Light Chain, ... | 著者 | Rohaim, A, Gong, L, Li, J. | 登録日 | 2020-02-29 | 公開日 | 2020-07-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.556 Å) | 主引用文献 | Open and Closed Structures of a Barium-Blocked Potassium Channel. J.Mol.Biol., 432, 2020
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3PHD
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![BU of 3phd by Molmil](/molmil-images/mine/3phd) | Crystal structure of human HDAC6 in complex with ubiquitin | 分子名称: | Histone deacetylase 6, Polyubiquitin, ZINC ION | 著者 | Dong, A, Qui, W, Ravichandran, M, Schuetz, A, Loppnau, P, Li, F, Mackenzie, F, Kozieradzki, I, Ouyang, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-11-03 | 公開日 | 2011-02-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini. J.Biol.Chem., 287, 2012
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6W8M
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![BU of 6w8m by Molmil](/molmil-images/mine/6w8m) | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | 分子名称: | 2-oxo-1,2-dihydroquinazoline-4-carboxylic acid, Nonstructural polyprotein | 著者 | Zhang, S, Garzan, A, Pathak, A.K, Augelli-Szafran, C.E, Wu, M. | 登録日 | 2020-03-20 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design. Plos One, 16, 2021
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6W8K
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![BU of 6w8k by Molmil](/molmil-images/mine/6w8k) | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | 分子名称: | 5,6-dimethyl-2-oxo-2,3-dihydropyrimidine-4-carboxylic acid, Nonstructural polyprotein | 著者 | Zhang, S, Garzan, A, Augelli-Szafran, C.E, Pathak, A.K, Wu, M. | 登録日 | 2020-03-20 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design. Plos One, 16, 2021
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6VLG
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![BU of 6vlg by Molmil](/molmil-images/mine/6vlg) | Crystal structure of mouse alpha 1,6-fucosyltransferase, FUT8 bound to GDP | 分子名称: | Alpha-(1,6)-fucosyltransferase, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ... | 著者 | Jarva, M.A, Dramicanin, M, Lingford, J.P, Mao, R, John, A, Goddard-Borger, E.D. | 登録日 | 2020-01-23 | 公開日 | 2020-02-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of substrate recognition and catalysis by fucosyltransferase 8. J.Biol.Chem., 295, 2020
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2OMD
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![BU of 2omd by Molmil](/molmil-images/mine/2omd) | Crystal structure of molybdopterin converting factor subunit 2 (aq_2181) from aquifex aeolicus VF5 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, FORMIC ACID, ... | 著者 | Jeyakanthan, J, Kanaujia, S.P, Vasuki Ranjani, C, Sekar, K, Agari, Y, Ebihara, A, Kuramitsu, S, Shinkai, A, Shiro, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2007-01-22 | 公開日 | 2008-01-29 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of molybdopterin converting factor subunit 2 (aq_2181) from aquifex aeolicus VF5 To be Published
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