3Q4U
Crystal structure of the ACVR1 kinase domain in complex with LDN-193189
Summary for 3Q4U
Entry DOI | 10.2210/pdb3q4u/pdb |
Related | 3MTF 3OOM |
Descriptor | Activin receptor type-1, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | structural genomics consortium, sgc, protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q04771 |
Total number of polymer chains | 4 |
Total formula weight | 142914.61 |
Authors | Chaikuad, A.,Sanvitale, C.,Cooper, C.D.O.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Allerston, C.K.,Krojer, T.,Vollmar, M.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-12-24, release date: 2011-02-09, Last modification date: 2023-09-13) |
Primary citation | Sanvitale, C.E.,Kerr, G.,Chaikuad, A.,Ramel, M.C.,Mohedas, A.H.,Reichert, S.,Wang, Y.,Triffitt, J.T.,Cuny, G.D.,Yu, P.B.,Hill, C.S.,Bullock, A.N. A new class of small molecule inhibitor of BMP signaling. Plos One, 8:e62721-e62721, 2013 Cited by PubMed: 23646137DOI: 10.1371/journal.pone.0062721 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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