3OOM
Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
Summary for 3OOM
Entry DOI | 10.2210/pdb3oom/pdb |
Related | 3MTF |
Descriptor | Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ... (5 entities in total) |
Functional Keywords | protein kinase, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q04771 |
Total number of polymer chains | 1 |
Total formula weight | 35994.98 |
Authors | Chaikuad, A.,Sanvitale, C.,Cooper, C.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Allerston, C.,Krojer, T.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-08-31, release date: 2010-10-13, Last modification date: 2023-11-01) |
Primary citation | Chaikuad, A.,Sanvitale, C.,Cooper, C.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Allerston, C.,Krojer, T.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507 To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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