7UKC
| Human Kv4.2-KChIP2 channel complex in an inactivated state, class 1, transmembrane region | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | 著者 | Zhao, H, Dai, Y, Lee, C.H. | 登録日 | 2022-04-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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7UKH
| Human Kv4.2-KChIP2-DPP6 channel complex in an open state, intracellular region | 分子名称: | CALCIUM ION, Isoform 2 of Kv channel-interacting protein 2, Potassium voltage-gated channel subfamily D member 2, ... | 著者 | Zhao, H, Dai, Y, Lee, C.H. | 登録日 | 2022-04-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | 主引用文献 | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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7UKE
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7UKG
| Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region | 分子名称: | Dipeptidyl-peptidase 6, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | 著者 | Zhao, H, Dai, Y, Lee, C.H. | 登録日 | 2022-04-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.24 Å) | 主引用文献 | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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7UK5
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7UKD
| Human Kv4.2-KChIP2 channel complex in an inactivated state, class 2, transmembrane region | 分子名称: | POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | 著者 | Zhao, H, Dai, Y, Lee, C.H. | 登録日 | 2022-04-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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7UKF
| Human Kv4.2-KChIP2 channel complex in a putative resting state, transmembrane region | 分子名称: | MERCURY (II) ION, POTASSIUM ION, Potassium voltage-gated channel subfamily D member 2 | 著者 | Zhao, H, Dai, Y, Lee, C.H. | 登録日 | 2022-04-01 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Activation and closed-state inactivation mechanisms of the human voltage-gated K V 4 channel complexes. Mol.Cell, 82, 2022
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5AYW
| Structure of a membrane complex | 分子名称: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | 著者 | Huang, Y, Han, L, Zheng, J. | 登録日 | 2015-09-14 | 公開日 | 2016-02-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.555 Å) | 主引用文献 | Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins Nat.Struct.Mol.Biol., 23, 2016
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5GJA
| Crystal structure of Arabidopsis thaliana ACO2 in complex with 2-PA | 分子名称: | 1-aminocyclopropane-1-carboxylate oxidase 2, PYRIDINE-2-CARBOXYLIC ACID, ZINC ION | 著者 | Sun, X.Z, Li, Y.X, He, W.R, Ji, C.G, Xia, P.X, Wang, Y.C, Du, S, Li, H.J, Raikhel, N, Xiao, J.Y, Guo, H.W. | 登録日 | 2016-06-28 | 公開日 | 2017-05-10 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nat Commun, 8, 2017
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6KJY
| Galectin-13 variant C136S/C138S | 分子名称: | Galactoside-binding soluble lectin 13 | 著者 | Su, J. | 登録日 | 2019-07-23 | 公開日 | 2019-10-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution. Glycobiology, 30, 2020
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6KJW
| Galectin-13 variant C136S | 分子名称: | Galactoside-binding soluble lectin 13 | 著者 | Su, J. | 登録日 | 2019-07-23 | 公開日 | 2019-10-16 | 最終更新日 | 2020-02-19 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution. Glycobiology, 30, 2020
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4JH0
| Crystal structure of dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) (DPP-IV-WT) complex with bms-767778 AKA 2-(3-(aminomethyl)-4-(2,4- dichlorophenyl)-2-methyl-5-oxo-5,7-dihydro-6h-pyrrolo[3,4- b]pyridin-6-yl)-n,n-dimethylacetamide | 分子名称: | 2-[3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-N,N-dimethylacetamide, Dipeptidyl peptidase 4 | 著者 | Klei, H.E. | 登録日 | 2013-03-04 | 公開日 | 2013-09-04 | 最終更新日 | 2013-10-09 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778). J.Med.Chem., 56, 2013
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5HN7
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5HNA
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6KJX
| Galectin-13 variant C138S | 分子名称: | Galactoside-binding soluble lectin 13 | 著者 | Su, J. | 登録日 | 2019-07-23 | 公開日 | 2019-10-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution. Glycobiology, 30, 2020
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5HN8
| Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1182 | 分子名称: | 2-{[3-hydroxy-5-(octyloxy)benzyl]sulfanyl}benzoic acid, Farnesyl pyrophosphate synthase, putative, ... | 著者 | Liu, Y.-L, Zhang, Y, Oldfield, E. | 登録日 | 2016-01-18 | 公開日 | 2016-09-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase. Biochemistry, 55, 2016
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5HN9
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6KXS
| Cryo-EM structure of human IgM-Fc in complex with the J chain and the ectodomain of pIgR | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | 著者 | Li, Y, Wang, G, Xiao, J. | 登録日 | 2019-09-12 | 公開日 | 2020-02-05 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural insights into immunoglobulin M. Science, 367, 2020
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6KPP
| BNC105 in complex with tubulin | 分子名称: | (6-methoxy-2-methyl-7-oxidanyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Wang, T, Wu, C, Pu, D. | 登録日 | 2019-08-15 | 公開日 | 2020-08-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.74524117 Å) | 主引用文献 | Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design. Biochem.Biophys.Res.Commun., 2020
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5XLZ
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2DHO
| Crystal structure of human IPP isomerase I in space group P212121 | 分子名称: | CHLORIDE ION, Isopentenyl-diphosphate delta-isomerase 1, MANGANESE (II) ION, ... | 著者 | Zhang, C, Wei, Z, Gong, W. | 登録日 | 2006-03-24 | 公開日 | 2007-06-05 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structures of human IPP isomerase: new insights into the catalytic mechanism J.Mol.Biol., 366, 2007
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7CJT
| Crystal Structure of SETDB1 Tudor domain in complexed with (R,R)-59 | 分子名称: | 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one, Histone-lysine N-methyltransferase SETDB1 | 著者 | Guo, Y.P, Liang, X, Mao, X, Wu, C, Luyi, H, Yang, S. | 登録日 | 2020-07-13 | 公開日 | 2021-04-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.474 Å) | 主引用文献 | Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60, 2021
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7CAJ
| Crystal structure of SETDB1 Tudor domain in complexed with Compound 2. | 分子名称: | 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-5H-pyrrolo[3,2-d]pyrimidin-4-one, Histone-lysine N-methyltransferase SETDB1 | 著者 | Guo, Y.P, Liang, X, Xin, M, Luyi, H, Chengyong, W, Yang, S.Y. | 登録日 | 2020-06-08 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60, 2021
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7S0J
| Crystal structure of Epstein-Barr virus gH/gL targeting antibody 769B10 | 分子名称: | 769B10 Fab Heavy chain, 769B10 Fab Light chain, GLYCEROL | 著者 | Chen, W.-H, Kanekiyo, M, Cohen, J.I, Joyce, M.G. | 登録日 | 2021-08-30 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. Immunity, 55, 2022
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7S08
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