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1WYW
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BU of 1wyw by Molmil
Crystal Structure of SUMO1-conjugated thymine DNA glycosylase
分子名称: CHLORIDE ION, G/T mismatch-specific thymine DNA glycosylase, MAGNESIUM ION, ...
著者Baba, D, Maita, N, Jee, J.G, Uchimura, Y, Saitoh, H, Sugasawa, K, Hanaoka, F, Tochio, H, Hiroaki, H, Shirakawa, M.
登録日2005-02-17
公開日2005-06-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.
Nature, 435, 2005
1WR1
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BU of 1wr1 by Molmil
The complex structure of Dsk2p UBA with ubiquitin
分子名称: Ubiquitin, Ubiquitin-like protein DSK2
著者Ohno, A, Jee, J.G, Fujiwara, K, Tenno, T, Goda, N, Tochio, H, Hiroaki, H, kobayashi, H, Shirakawa, M.
登録日2004-10-08
公開日2005-04-19
最終更新日2023-09-27
実験手法SOLUTION NMR
主引用文献Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition.
Structure, 13, 2005
1X0K
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BU of 1x0k by Molmil
Crystal Structure of Bacteriorhodopsin at pH 10
分子名称: 2,3-DI-O-PHYTANLY-3-SN-GLYCERO-1-PHOSPHORYL-3'-SN-GLYCEROL-1'-PHOSPHATE, 2,3-DI-PHYTANYL-GLYCEROL, Bacteriorhodopsin, ...
著者Okumura, H, Murakami, M, Kouyama, T.
登録日2005-03-23
公開日2005-08-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structures of Acid Blue and Alkaline Purple Forms of Bacteriorhodopsin
J.Mol.Biol., 351, 2005
1WR0
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BU of 1wr0 by Molmil
Structural characterization of the MIT domain from human Vps4b
分子名称: SKD1 protein
著者Takasu, H, Jee, J.G, Ohno, A, Goda, N, Fujiwara, K, Tochio, H, Shirakawa, M, Hiroaki, H, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-10-07
公開日2005-08-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Structural characterization of the MIT domain from human Vps4b
Biochem.Biophys.Res.Commun., 334, 2005
1WNJ
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BU of 1wnj by Molmil
NMR structure of human coactosin-like protein
分子名称: Coactosin-like protein
著者Liepinsh, E, Rakonjac, M, Boissonneault, V, Provost, P, Samuelsson, B, Radmark, O, Otting, G.
登録日2004-08-05
公開日2004-08-17
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献NMR structure of human coactosin-like protein
J.Biomol.Nmr, 30, 2004
1X0I
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BU of 1x0i by Molmil
Crystal Structure of the Acid Blue Form of Bacteriorhodopsin
分子名称: 2,3-DI-O-PHYTANLY-3-SN-GLYCERO-1-PHOSPHORYL-3'-SN-GLYCEROL-1'-PHOSPHATE, 2,3-DI-PHYTANYL-GLYCEROL, Bacteriorhodopsin, ...
著者Okumura, H, Murakami, M, Kouyama, T.
登録日2005-03-23
公開日2005-08-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structures of Acid Blue and Alkaline Purple Forms of Bacteriorhodopsin
J.Mol.Biol., 351, 2005
1VGO
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BU of 1vgo by Molmil
Crystal Structure of Archaerhodopsin-2
分子名称: Archaerhodopsin 2, RETINAL, SULFATE ION, ...
著者Yoshimura, K, Enami, N, Murakami, M, Okumura, H, Ihara, K, Kouyama, T.
登録日2004-04-28
公開日2005-10-04
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of archaerhodopsin-1 and -2: Common structural motif in archaeal light-driven proton pumps
J.Mol.Biol., 358, 2006
2D07
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BU of 2d07 by Molmil
Crystal Structure of SUMO-3-modified Thymine-DNA Glycosylase
分子名称: G/T mismatch-specific thymine DNA glycosylase, Ubiquitin-like protein SMT3B
著者Baba, D, Maita, N, Jee, J.G, Uchimura, Y, Saitoh, H, Sugasawa, K, Hanaoka, F, Tochio, H, Hiroaki, H, Shirakawa, M.
登録日2005-07-26
公開日2006-06-06
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of SUMO-3-modified Thymine-DNA Glycosylase
J.Mol.Biol., 359, 2006
2D2P
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BU of 2d2p by Molmil
The solution structure of micelle-bound peptide
分子名称: Pituitary adenylate cyclase activating polypeptide-38
著者Tateishi, Y, Jee, J.G, Inooka, H, Tochio, H, Hiroaki, H, Shirakawa, M.
登録日2005-09-14
公開日2006-09-26
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献The solution structure of micelle-bound peptide
To be Published
2DHT
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BU of 2dht by Molmil
Crystal structure of isocitrate dehydrogenase from Sulfolobus tokodaii strain7
分子名称: 409aa long hypothetical NADP-dependent isocitrate dehydrogenase
著者Kondo, H, Murakami, M, Ihara, K, Suzuki, S, Kouyama, T.
登録日2006-03-25
公開日2007-03-27
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of isocitrate dehydrogenase of Sulfolobus tokodaii strain7
To be Published
3WA0
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BU of 3wa0 by Molmil
Crystal structure of merlin complexed with DCAF1/VprBP
分子名称: Merlin, Protein VPRBP
著者Mori, T, Gotoh, S, Shirakawa, M, Hakoshima, T.
登録日2013-04-20
公開日2014-05-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function.
Genes Cells, 19, 2014
2Z5V
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BU of 2z5v by Molmil
Solution structure of the TIR domain of human MyD88
分子名称: Myeloid differentiation primary response protein MyD88
著者Ohnishi, H, Tochio, H, Hiroaki, H, Kondo, N, Kato, Z, Shirakawa, M.
登録日2007-07-19
公開日2008-08-05
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.
Proc.Natl.Acad.Sci.USA, 2009
7ATH
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BU of 7ath by Molmil
Crystal structure of UipA
分子名称: UipA, ZINC ION
著者Bremond, N, Gallois, N, Legrand, P, Chapon, V, Arnoux, P.
登録日2020-10-30
公開日2021-10-06
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.343 Å)
主引用文献Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria.
Isme J, 16, 2022
7ATK
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BU of 7atk by Molmil
Crystal structure of UipA in complex with Uranium
分子名称: URANIUM ATOM, UipA, ZINC ION
著者Bremond, N, Gallois, N, Legrand, P, Chapon, V, Arnoux, P.
登録日2020-10-30
公開日2021-10-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.855 Å)
主引用文献Discovery and characterization of UipA, a uranium- and iron-binding PepSY protein involved in uranium tolerance by soil bacteria.
Isme J, 16, 2022
5BCA
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BU of 5bca by Molmil
BETA-AMYLASE FROM BACILLUS CEREUS VAR. MYCOIDES
分子名称: CALCIUM ION, PROTEIN (1,4-ALPHA-D-GLUCAN MALTOHYDROLASE.)
著者Oyama, T, Kusunoki, M, Kishimoto, Y, Takasaki, Y, Nitta, Y.
登録日1999-03-12
公開日2000-03-15
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of beta-amylase from Bacillus cereus var. mycoides at 2.2 A resolution.
J.Biochem.(Tokyo), 125, 1999
8H7X
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BU of 8h7x by Molmil
Crystal structure of EGFR T790M/C797S mutant in complex with brigatinib
分子名称: 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine, Epidermal growth factor receptor
著者Kukimoto-Niino, M, Shirouzu, M.
登録日2022-10-21
公開日2023-10-25
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.404 Å)
主引用文献A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer.
NPJ Precis Oncol, 8, 2024
5B3H
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BU of 5b3h by Molmil
The crystal structure of the JACKDAW/IDD10 bound to the heterodimeric SHR-SCR complex
分子名称: Protein SCARECROW, Protein SHORT-ROOT, ZINC ION, ...
著者Hirano, Y, Suyama, T, Nakagawa, M, Hakoshima, T.
登録日2016-02-29
公開日2017-03-01
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD
Nat Plants, 3, 2017
6FEK
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BU of 6fek by Molmil
Oncogenic point mutation of RET receptor tyrosine kinase
分子名称: ADENOSINE, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret
著者McDonald, N.Q, Kohno, T.
登録日2018-01-02
公開日2018-02-28
最終更新日2018-05-02
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A secondary RET mutation in the activation loop conferring resistance to vandetanib.
Nat Commun, 9, 2018
6CKX
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BU of 6ckx by Molmil
Structure of CDK12/CycK in complex with a small molecule inhibitor N-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-((1r,4r)-4-(quinazolin-2-ylamino)cyclohexyl)acetamide
分子名称: Cyclin-K, Cyclin-dependent kinase 12, MAGNESIUM ION, ...
著者Klein, M.G.
登録日2018-03-01
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
J. Med. Chem., 61, 2018
4J19
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Structure of a novel telomere repeat binding protein bound to DNA
分子名称: CHLORIDE ION, DNA (5'-D(*CP*TP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*AP*AP*CP*A)-3'), ...
著者Kappei, D, Butter, F, Benda, C, Scheibe, M, Draskovic, I, Stevense, M, Lopes Novo, C, Basquin, C, Krastev, D.B, Kittler, R, Jessberger, R, Londono-Vallejo, A.J, Mann, M, Buchholz, F.
登録日2013-02-01
公開日2013-05-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.
Embo J., 32, 2013
5IJC
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The crystal structure of mouse TLR4/MD-2/neoseptin-3 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte antigen 96, ...
著者Wang, Y, Su, L, Morin, M.D, Jones, B.T, Whitby, L.R, Surakattula, M, Huang, H, Shi, H, Choi, J.H, Wang, K, Moresco, E.M, Berger, M, Zhan, X, Zhang, H, Boger, D.L, Beutler, B.
登録日2016-03-01
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IJB
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The ligand-free structure of the mouse TLR4/MD-2 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte antigen 96, ...
著者Wang, Y, Su, L, Morin, M.D, Jones, B.T, Whitby, L.R, Surakattula, M, Huang, H, Shi, H, Choi, J.H, Wang, K, Moresco, E.M, Berger, M, Zhan, X, Zhang, H, Boger, D.L, Beutler, B.
登録日2016-03-01
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IJD
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The crystal structure of mouse TLR4/MD-2/lipid A complex
分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wang, Y, Su, L, Morin, M.D, Jones, B.T, Whitby, L.R, Surakattula, M, Huang, H, Shi, H, Choi, J.H, Wang, K, Moresco, E.M, Berger, M, Zhan, X, Zhang, H, Boger, D.L, Beutler, B.
登録日2016-03-01
公開日2016-04-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Proc.Natl.Acad.Sci.USA, 113, 2016
6EDL
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hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine
分子名称: ALK tyrosine kinase receptor, N-[(1S)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine
著者Lane, W, Saikatendu, K.
登録日2018-08-09
公開日2019-05-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.799 Å)
主引用文献Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
J.Med.Chem., 62, 2019
6EBW
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hALK in complex with compound 9 (6-(((1S)-1-(5-Fluoropyridin-2-yl)ethyl)amino)-1-(3-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)(morpholin-4-yl)methanone
分子名称: ALK tyrosine kinase receptor, [6-{[(1S)-1-(5-fluoropyridin-2-yl)ethyl]amino}-1-(5-methyl-1H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl](morpholin-4-yl)methanone
著者Lane, W, Saikatendu, K.
登録日2018-08-07
公開日2019-05-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.455 Å)
主引用文献Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
J.Med.Chem., 62, 2019

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