6WVA
 
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6WVF
 | | E.coli DsbB C104S with ubiquinone | | 分子名称: | Green fluorescent protein,Disulfide bond formation protein B,Green fluorescent protein, UBIQUINONE-1 | | 著者 | Liu, S, Li, W. | | 登録日 | 2020-05-05 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Termini restraining of small membrane proteins enables structure determination at near-atomic resolution.
Sci Adv, 6, 2020
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6WVI
 | | VKOR-like from Takifugu rubripes | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Vitamin K epoxide reductase-like protein, termini restrained by green fluorescent protein | | 著者 | Liu, S, Sukumar, N, Li, W. | | 登録日 | 2020-05-06 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.
Science, 371, 2021
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6WVE
 | | Chicken SPCS1 | | 分子名称: | Green fluorescent protein,Chicken Signal Peptidase Complex Subunit 1,Green fluorescent protein | | 著者 | Liu, S, Li, W. | | 登録日 | 2020-05-05 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.429 Å) | | 主引用文献 | Termini restraining of small membrane proteins enables structure determination at near-atomic resolution.
Sci Adv, 6, 2020
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6WV7
 | | Human VKOR with Chlorophacinone | | 分子名称: | Chlorophacinone, Vitamin K epoxide reductase, termini restrained by green fluorescent protein | | 著者 | Liu, S, Sukumar, N, Li, W. | | 登録日 | 2020-05-05 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.483 Å) | | 主引用文献 | Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.
Science, 371, 2021
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6WVD
 | | Human JAGN1 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Green fluorescent protein, Protein jagunal homolog 1 chimera | | 著者 | Yang, Y, Liu, S, Li, W. | | 登録日 | 2020-05-05 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Termini restraining of small membrane proteins enables structure determination at near-atomic resolution.
Sci Adv, 6, 2020
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6SF3
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6SF2
 | | Ternary complex of human bone morphogenetic protein 9 (BMP9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (ALK1). | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 2, Serine/threonine-protein kinase receptor R3 | | 著者 | Salmon, R.M, Guo, J, Yu, M, Li, W. | | 登録日 | 2019-07-31 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.
Nat Commun, 11, 2020
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6SF1
 | | Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like kinase 1 (ALK1). | | 分子名称: | Bone morphogenetic protein 10, NICKEL (II) ION, Serine/threonine-protein kinase receptor R3 | | 著者 | Salmon, R.M, Guo, J, Yu, M, Li, W. | | 登録日 | 2019-07-30 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.
Nat Commun, 11, 2020
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2AJF
 | | Structure of SARS coronavirus spike receptor-binding domain complexed with its receptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme-Related Carboxypeptidase (Ace2), CHLORIDE ION, ... | | 著者 | Li, F, Li, W, Farzan, M, Harrison, S.C. | | 登録日 | 2005-08-01 | | 公開日 | 2005-09-20 | | 最終更新日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.
Science, 309, 2005
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2OB7
 | | Structure of tmRNA-(SmpB)2 complex as inferred from cryo-EM | | 分子名称: | 16S ribosomal RNA, SsrA-binding protein, transfer-messenger RNA | | 著者 | Frank, J, Felden, B, Gillet, R, Li, W. | | 登録日 | 2006-12-18 | | 公開日 | 2007-01-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (13.6 Å) | | 主引用文献 | Scaffolding as an organizing principle in trans-translation. The roles of small protein B and ribosomal protein S1.
J.Biol.Chem., 282, 2007
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6O5M
 | | Tubulin-RB3_SLD-TTL in complex with compound 10bb | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2019-03-04 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
J.Med.Chem., 62, 2019
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6O5N
 | | Tubulin-RB3_SLD-TTL in complex with compound 10ab | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2019-03-04 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.003 Å) | | 主引用文献 | Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
J.Med.Chem., 62, 2019
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4EL1
 | | Crystal structure of oxidized hPDI (abb'xa') | | 分子名称: | Protein disulfide-isomerase | | 著者 | Wang, C, Li, W, Ren, J, Ke, H, Gong, W, Feng, W, Wang, C.-C. | | 登録日 | 2012-04-10 | | 公開日 | 2013-04-10 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.883 Å) | | 主引用文献 | Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase
Antioxid Redox Signal, 19, 2013
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4EKZ
 | | Crystal structure of reduced hPDI (abb'xa') | | 分子名称: | Protein disulfide-isomerase | | 著者 | Wang, C, Li, W, Ren, J, Ke, H, Gong, W, Feng, W, Wang, C.-C. | | 登録日 | 2012-04-10 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase
Antioxid Redox Signal, 19, 2013
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6KZI
 | | Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine derivatives | | 分子名称: | 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, Serine/threonine-protein kinase pim-1 | | 著者 | Zhang, W, Wan, X, Li, W, Xie, Y, Huang, N. | | 登録日 | 2019-09-24 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors.
J.Chem.Inf.Model., 60, 2020
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3JA8
 | | Cryo-EM structure of the MCM2-7 double hexamer | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Minichromosome Maintenance 2, Minichromosome Maintenance 3, ... | | 著者 | Li, N, Zhai, Y, Zhang, Y, Li, W, Yang, M, Lei, J, Tye, B.K, Gao, N. | | 登録日 | 2015-05-09 | | 公開日 | 2015-08-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of the eukaryotic MCM complex at 3.8 angstrom
Nature, 524, 2015
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6BR1
 | | Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[2,3-d]pyrimidine, CALCIUM ION, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2017-11-29 | | 公開日 | 2018-06-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.304 Å) | | 主引用文献 | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
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3D94
 | | Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP | | 分子名称: | 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine, CALCIUM ION, Insulin-like growth factor 1 receptor beta chain | | 著者 | Wu, J, Li, W, Miller, W.T, Hubbard, S.R. | | 登録日 | 2008-05-26 | | 公開日 | 2008-07-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
Embo J., 27, 2008
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3KBH
 | | Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein | | 著者 | Wu, K, Li, W, Peng, G, Li, F. | | 登録日 | 2009-10-20 | | 公開日 | 2009-12-15 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor.
Proc.Natl.Acad.Sci.USA, 106, 2009
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6BRF
 | | Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4b | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[3,2-d]pyrimidine, CALCIUM ION, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2017-11-30 | | 公開日 | 2018-06-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
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6BRY
 | | Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 6a | | 分子名称: | 1-(2-chlorofuro[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2017-12-01 | | 公開日 | 2018-06-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
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6BS2
 | | Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 8b | | 分子名称: | 1-(3,6-dimethyl[1,2]oxazolo[5,4-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2017-12-01 | | 公開日 | 2018-06-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
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4NV5
 | | C50A mutant of Synechococcus VKOR, C2 crystal form (dehydrated) | | 分子名称: | UBIQUINONE-10, VKORC1/thioredoxin domain protein | | 著者 | Liu, S, Cheng, W, Fowle Grider, R, Shen, G, Li, W. | | 登録日 | 2013-12-04 | | 公開日 | 2014-02-12 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer.
Nat Commun, 5, 2014
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4NV6
 | | C212A mutant of Synechococcus VKOR | | 分子名称: | UBIQUINONE-10, VKORC1/thioredoxin domain protein | | 著者 | Liu, S, Cheng, W, Fowle Grider, R, Shen, G, Li, W. | | 登録日 | 2013-12-04 | | 公開日 | 2014-02-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (4.19 Å) | | 主引用文献 | Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer.
Nat Commun, 5, 2014
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