7MXA
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![BU of 7mxa by Molmil](/molmil-images/mine/7mxa) | PRMT5:MEP50 complexed with inhibitor PF-06855800 | 分子名称: | 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2021-05-18 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.713 Å) | 主引用文献 | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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7MXC
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![BU of 7mxc by Molmil](/molmil-images/mine/7mxc) | PRMT5:MEP50 complexed with adenosine | 分子名称: | ADENOSINE, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2021-05-18 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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7MXG
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![BU of 7mxg by Molmil](/molmil-images/mine/7mxg) | PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06855800 | 分子名称: | 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 | 著者 | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | 登録日 | 2021-05-19 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.395 Å) | 主引用文献 | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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6LBC
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![BU of 6lbc by Molmil](/molmil-images/mine/6lbc) | shrimp ferritin-T158R | 分子名称: | FE (III) ION, Ferritin | 著者 | Zhao, G, Chen, H, Zhang, T. | 登録日 | 2019-11-14 | 公開日 | 2020-11-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Construction of thermally robust and porous shrimp ferritin crystalline for molecular encapsulation through intermolecular arginine-arginine attractions. Food Chem, 349, 2021
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6L5L
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![BU of 6l5l by Molmil](/molmil-images/mine/6l5l) | Crystal structure of human DEAD-box RNA helicase DDX21 at apo state | 分子名称: | MAGNESIUM ION, Nucleolar RNA helicase 2 | 著者 | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | 登録日 | 2019-10-24 | 公開日 | 2020-06-17 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci, 7, 2020
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6L5D
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![BU of 6l5d by Molmil](/molmil-images/mine/6l5d) | |
6L5N
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![BU of 6l5n by Molmil](/molmil-images/mine/6l5n) | Crystal structure of human DEAD-box RNA helicase DDX21 at post-unwound state | 分子名称: | MAGNESIUM ION, Nucleolar RNA helicase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | 登録日 | 2019-10-24 | 公開日 | 2020-06-17 | 最終更新日 | 2020-08-12 | 実験手法 | X-RAY DIFFRACTION (2.242 Å) | 主引用文献 | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci, 7, 2020
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5XEY
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![BU of 5xey by Molmil](/molmil-images/mine/5xey) | Discovery and structural analysis of a phloretin hydrolase from the opportunistic pathogen Mycobacterium abscessus | 分子名称: | 1-[2,4,6-tris(oxidanyl)phenyl]ethanone, phloretin hydrolase | 著者 | He, Y.X, Han, J.T, Jia, W.J, Zhang, Z. | 登録日 | 2017-04-06 | 公開日 | 2018-05-02 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus. FEBS J., 2019
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5XHZ
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![BU of 5xhz by Molmil](/molmil-images/mine/5xhz) | |
7YL7
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![BU of 7yl7 by Molmil](/molmil-images/mine/7yl7) | Structure of hIAPP-TF-type3 | 分子名称: | Islet amyloid polypeptide | 著者 | Li, D, Zhang, X. | 登録日 | 2022-07-25 | 公開日 | 2022-12-28 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A new polymorphism of human amylin fibrils with similar protofilaments and a conserved core. Iscience, 25, 2022
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7D39
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![BU of 7d39 by Molmil](/molmil-images/mine/7d39) | FLR-apo | 分子名称: | Cd1, FLAVIN MONONUCLEOTIDE | 著者 | Hong, S, Yang, G.H, Zhang, P. | 登録日 | 2020-09-18 | 公開日 | 2021-03-03 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria. Nat Commun, 12, 2021
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7D3B
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![BU of 7d3b by Molmil](/molmil-images/mine/7d3b) | flavone reductase | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, Cd1, FLAVIN MONONUCLEOTIDE | 著者 | Hong, S, Yang, G.H, Zhang, P. | 登録日 | 2020-09-18 | 公開日 | 2021-03-03 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria. Nat Commun, 12, 2021
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7D38
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![BU of 7d38 by Molmil](/molmil-images/mine/7d38) | flavone reductase | 分子名称: | Cd1, FLAVIN MONONUCLEOTIDE, chrysin | 著者 | Hong, S, Yang, G.H, Zhang, P. | 登録日 | 2020-09-18 | 公開日 | 2021-03-03 | 実験手法 | X-RAY DIFFRACTION (2.649 Å) | 主引用文献 | Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria. Nat Commun, 12, 2021
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7D3A
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![BU of 7d3a by Molmil](/molmil-images/mine/7d3a) | flavone reductase | 分子名称: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Cd1, FLAVIN MONONUCLEOTIDE | 著者 | Hong, S, Yang, G.H, Zhang, P. | 登録日 | 2020-09-18 | 公開日 | 2021-03-03 | 最終更新日 | 2021-09-29 | 実験手法 | X-RAY DIFFRACTION (2.552 Å) | 主引用文献 | Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria. Nat Commun, 12, 2021
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6L5O
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![BU of 6l5o by Molmil](/molmil-images/mine/6l5o) | Crystal structure of human DEAD-box RNA helicase DDX21 at post-hydrolysis state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Chen, Z.J, Hu, X.J, Zhou, Z, Li, J.X. | 登録日 | 2019-10-24 | 公開日 | 2020-06-17 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation. Adv Sci, 7, 2020
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6LBD
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![BU of 6lbd by Molmil](/molmil-images/mine/6lbd) | shrimp ferritin T158R G159R | 分子名称: | CHLORIDE ION, FE (III) ION, Ferritin | 著者 | Zhao, G, Chen, H. | 登録日 | 2019-11-14 | 公開日 | 2020-11-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.386 Å) | 主引用文献 | Construction of thermally robust and porous shrimp ferritin crystalline for molecular encapsulation through intermolecular arginine-arginine attractions. Food Chem, 349, 2021
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5XOO
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![BU of 5xoo by Molmil](/molmil-images/mine/5xoo) | The structure of hydra Fam20 with sugar | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE, Glycosaminoglycan xylosylkinase, ... | 著者 | Zhang, H, Xiao, J. | 登録日 | 2017-05-29 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structure and evolution of the Fam20 kinases Nat Commun, 9, 2018
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5XE5
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![BU of 5xe5 by Molmil](/molmil-images/mine/5xe5) | Discovery and structural analysis of a phloretin hydrolase from the opportunistic pathogen Mycobacterium abscessus | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, phloretin hydrolase | 著者 | He, Y.X, Han, J.T, Jia, W.J, Zhang, Z. | 登録日 | 2017-04-01 | 公開日 | 2018-05-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus. FEBS J., 2019
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7YSU
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![BU of 7ysu by Molmil](/molmil-images/mine/7ysu) | Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ... | 著者 | Mohammadi, M, Chen, L. | 登録日 | 2022-08-13 | 公開日 | 2023-04-19 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for FGF hormone signalling. Nature, 618, 2023
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7YSH
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![BU of 7ysh by Molmil](/molmil-images/mine/7ysh) | Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, COPPER (II) ION, Fibroblast growth factor 23, ... | 著者 | Mohammadi, M, Chen, L. | 登録日 | 2022-08-12 | 公開日 | 2023-04-19 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Structural basis for FGF hormone signalling. Nature, 618, 2023
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7YSW
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![BU of 7ysw by Molmil](/molmil-images/mine/7ysw) | Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ... | 著者 | Mohammadi, M, Chen, L. | 登録日 | 2022-08-13 | 公開日 | 2023-06-14 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural basis for FGF hormone signalling. Nature, 618, 2023
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6M11
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![BU of 6m11 by Molmil](/molmil-images/mine/6m11) | Crystal structure of Rnase L in complex with Sunitinib | 分子名称: | 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, PHOSPHATE ION, ... | 著者 | Tang, J, Huang, H. | 登録日 | 2020-02-24 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Sunitinib inhibits RNase L by destabilizing its active dimer conformation. Biochem.J., 477, 2020
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7D7F
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![BU of 7d7f by Molmil](/molmil-images/mine/7d7f) | Structure of PKD1L3-CTD/PKD2L1 in calcium-bound state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ... | 著者 | Su, Q, Shi, Y.G. | 登録日 | 2020-10-03 | 公開日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel. Nat Commun, 12, 2021
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5XZW
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![BU of 5xzw by Molmil](/molmil-images/mine/5xzw) | Crystal structure of Rad53 1-466 | 分子名称: | Serine/threonine-protein kinase RAD53 | 著者 | Weng, J.H, Tsai, M.D. | 登録日 | 2017-07-14 | 公開日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation Biochemistry, 56, 2017
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6LOZ
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![BU of 6loz by Molmil](/molmil-images/mine/6loz) | crystal structure of alpha-momorcharin in complex with adenine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENINE, Ribosome-inactivating protein momordin I | 著者 | Fan, X, Jin, T. | 登録日 | 2020-01-07 | 公開日 | 2020-11-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | Atomic-resolution structures of type I ribosome inactivating protein alpha-momorcharin with different substrate analogs. Int.J.Biol.Macromol., 164, 2020
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