7XTT
| The structure of engineered TfCut S130A in complex with MHET | 分子名称: | 1,2-ETHANEDIOL, 4-(2-hydroxyethyloxycarbonyl)benzoic acid, SODIUM ION, ... | 著者 | Yang, Y, Jiang, P.C, Huang, J.W, Chen, C.-C, Guo, R.-T. | 登録日 | 2022-05-18 | 公開日 | 2023-03-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Complete bio-degradation of poly(butylene adipate-co-terephthalate) via engineered cutinases. Nat Commun, 14, 2023
|
|
2ZAK
| Orthorhombic crystal structure of precursor E. coli isoaspartyl peptidase/L-asparaginase (EcAIII) with active-site T179A mutation | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, L-asparaginase precursor, ... | 著者 | Michalska, K, Hernandez-Santoyo, A, Jaskolski, M. | 登録日 | 2007-10-07 | 公開日 | 2008-03-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Crystal packing of plant-type L-asparaginase from Escherichia coli Acta Crystallogr.,Sect.D, 64, 2008
|
|
6BB3
| |
2EW6
| Structure of Helicobacter Pylori peptide deformylase in complex with inhibitor | 分子名称: | (2E)-3-(3,4-DIHYDROXYPHENYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]ACRYLAMIDE, COBALT (II) ION, peptide deformylase | 著者 | Cai, J. | 登録日 | 2005-11-02 | 公開日 | 2006-10-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation Protein Sci., 15, 2006
|
|
2H42
| Crystal structure of PDE5 in complex with sildenafil | 分子名称: | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, MAGNESIUM ION, ZINC ION, ... | 著者 | Wang, H, Ke, H. | 登録日 | 2006-05-23 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
|
|
2H44
| Crystal structure of PDE5A1 in complex with icarisid II | 分子名称: | 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE, MAGNESIUM ION, ZINC ION, ... | 著者 | Wang, H, Ke, H. | 登録日 | 2006-05-23 | 公開日 | 2006-06-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
|
|
2H5E
| |
5GVA
| WD40 domain of human AND-1 | 分子名称: | WD repeat and HMG-box DNA-binding protein 1 | 著者 | Guan, C.C, Li, J. | 登録日 | 2016-09-04 | 公開日 | 2017-04-19 | 最終更新日 | 2017-06-21 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome J. Biol. Chem., 292, 2017
|
|
2EW7
| Crystal Structure of Helicobacter Pylori peptide deformylase | 分子名称: | COBALT (II) ION, peptide deformylase | 著者 | Cai, J. | 登録日 | 2005-11-02 | 公開日 | 2006-10-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation Protein Sci., 15, 2006
|
|
5GVB
| SepB domain of human AND-1 | 分子名称: | WD repeat and HMG-box DNA-binding protein 1 | 著者 | Guan, C.C, Li, J. | 登録日 | 2016-09-05 | 公開日 | 2017-04-19 | 最終更新日 | 2017-06-21 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome. J. Biol. Chem., 292, 2017
|
|
6JUJ
| Crystal structure of Formate dehydrogenase mutant V198I/C256I/P260S/E261P/S381N/S383F from Pseudomonas sp. 101in complex with non-natural cofactor Nicotinamide Cytosine Dinucleotide | 分子名称: | Formate dehydrogenase, GLYCEROL, [[(2S,3S,4R,5S)-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4R,5S)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | 著者 | Feng, Y, Guo, X, Xue, S, Zhao, Z. | 登録日 | 2019-04-14 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.183 Å) | 主引用文献 | Structure-Guided Design of Formate Dehydrogenase for Regeneration of a Non-Natural Redox Cofactor. Chemistry, 26, 2020
|
|
2GYX
| Crystal structure of DB884- D(CGCGAATTCGCG)2 complex at 1.86 A resolution. | 分子名称: | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, N,N'-(1H-PYRROLE-2,5-DIYLDI-4,1-PHENYLENE)DIBENZENECARBOXIMIDAMIDE | 著者 | Lee, M.P.H, Neidle, S. | 登録日 | 2006-05-10 | 公開日 | 2007-05-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. J.Am.Chem.Soc., 129, 2007
|
|
3TV3
| |
3L15
| |
7W7P
| |
7TEU
| Crystal structure of JAK2 JH1 with type II inhibitor YLIU-04-105-1 | 分子名称: | 3-{(4S)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, Tyrosine-protein kinase JAK2 | 著者 | Hubbard, S.R. | 登録日 | 2022-01-05 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. Cell Chem Biol, 30, 2023
|
|
5YYL
| Structure of Major Royal Jelly Protein 1 Oligomer | 分子名称: | (3beta,14beta,17alpha)-ergosta-5,24(28)-dien-3-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tian, W, Chen, Z. | 登録日 | 2017-12-10 | 公開日 | 2018-08-08 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Architecture of the native major royal jelly protein 1 oligomer. Nat Commun, 9, 2018
|
|
7UAD
| Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484 | 分子名称: | 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, Tyrosine-protein phosphatase non-receptor type 2 | 著者 | Longenecker, K.L, Qiu, W, Sun, Q, Frost, J.M. | 登録日 | 2022-03-12 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.044 Å) | 主引用文献 | The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, 622, 2023
|
|
7XG1
| CryoEM structure of type IV-A Csf-crRNA binary complex | 分子名称: | Csf1, Csf2, Csf3, ... | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | 登録日 | 2022-04-02 | 公開日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment Mol.Cell, 83, 2023
|
|
7XG3
| CryoEM structure of type IV-A CasDinG bound NTS-nicked Csf-crRNA-dsDNA quaternary complex | 分子名称: | Csf1, Csf2, Csf3, ... | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | 登録日 | 2022-04-02 | 公開日 | 2023-08-09 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
|
|
7XFZ
| CryoEM structure of type IV-A Csf-crRNAsp14-dsDNA ternary complex | 分子名称: | Csf1, Csf2, Csf3, ... | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | 登録日 | 2022-04-02 | 公開日 | 2023-08-09 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
|
|
7XG0
| CryoEM structure of type IV-A Csf-crRNA-dsDNA ternary complex | 分子名称: | Csf1, Csf2, Csf3, ... | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | 登録日 | 2022-04-02 | 公開日 | 2023-08-09 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
|
|
7XG4
| CryoEM structure of type IV-A CasDinG bound NTS-nicked Csf-crRNA-dsDNA quaternary complex in a second state | 分子名称: | Csf1, Csf2, Csf3, ... | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | 登録日 | 2022-04-02 | 公開日 | 2023-08-09 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
|
|
7XG2
| CryoEM structure of type IV-A NTS-nicked dsDNA bound Csf-crRNA ternary complex | 分子名称: | Csf1, Csf2, Csf3, ... | 著者 | Zhang, J.T, Cui, N, Huang, H.D, Jia, N. | 登録日 | 2022-04-02 | 公開日 | 2023-08-09 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment. Mol.Cell, 83, 2023
|
|
8GEL
| Cryo-EM structure of synthetic tetrameric building block sC4 | 分子名称: | sC4 | 著者 | Redler, R.L, Huddy, T.F, Hsia, Y, Baker, D, Ekiert, D, Bhabha, G. | 登録日 | 2023-03-07 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Blueprinting extendable nanomaterials with standardized protein blocks. Nature, 627, 2024
|
|