2IJA
| Human N-acetyltransferase 1 F125S mutant | 分子名称: | ACETAMIDE, Arylamine N-acetyltransferase 1, SODIUM ION, ... | 著者 | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2006-09-29 | 公開日 | 2006-11-28 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | 主引用文献 | The Crystal Structure of Human N-acetyltransferase 1 mutant, F125S To be Published
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2GIV
| Human MYST histone acetyltransferase 1 | 分子名称: | ACETYL COENZYME *A, CHLORIDE ION, Probable histone acetyltransferase MYST1, ... | 著者 | Min, J, Wu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2006-03-29 | 公開日 | 2006-04-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | The Crystal Structure of Human MYST histone acetyltransferase 1 in complex with acetylcoenzyme A To be Published
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9BJU
| Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5 | 分子名称: | 1,2-ETHANEDIOL, 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE, ACETATE ION, ... | 著者 | Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A. | 登録日 | 2024-04-25 | 公開日 | 2024-05-29 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability. J.Med.Chem., 67, 2024
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9BOL
| Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5 | 分子名称: | (4R)-1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Murray, J.M, Wu, H, Fuhrmann, J, Fairbrother, W.J, DiPasquale, A. | 登録日 | 2024-05-03 | 公開日 | 2024-05-29 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability. J.Med.Chem., 67, 2024
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4U6V
| Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody | 分子名称: | Alpha-hemolysin, Fab, antigen binding fragment, ... | 著者 | Oganesyan, V.Y, Peng, L, Damschroder, M.M, Cheng, L, Sadowska, A, Tkaczyk, C, Sellman, B, Wu, H, Dall'Acqua, W.F. | 登録日 | 2014-07-29 | 公開日 | 2014-09-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody. J.Biol.Chem., 289, 2014
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1S8K
| Solution Structure of BmKK4, A Novel Potassium Channel Blocker from Scorpion Buthus martensii Karsch, 25 structures | 分子名称: | Toxin BmKK4 | 著者 | Zhang, N, Chen, X, Li, M, Cao, C, Wang, Y, Hu, G, Wu, H. | 登録日 | 2004-02-02 | 公開日 | 2005-02-08 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of BmKK4, the first member of subfamily alpha-KTx 17 of scorpion toxins Biochemistry, 43, 2004
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2BW7
| A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen | 分子名称: | 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE, ADENYLATE CYCLASE, CALCIUM ION, ... | 著者 | Steegborn, C, Litvin, T.N, Hess, K.C, Capper, A.B, Taussig, R, Buck, J, Levin, L.R, Wu, H. | 登録日 | 2005-07-12 | 公開日 | 2005-07-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of its Complex with Catechol Estrogen J.Biol.Chem., 280, 2005
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1CA4
| STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2) | 分子名称: | PROTEIN (TNF RECEPTOR ASSOCIATED FACTOR 2) | 著者 | Park, Y.C, Burkitt, V, Villa, A.R, Tong, L, Wu, H. | 登録日 | 1999-02-23 | 公開日 | 1999-04-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for self-association and receptor recognition of human TRAF2. Nature, 398, 1999
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3DB5
| Crystal structure of methyltransferase domain of human PR domain-containing protein 4 | 分子名称: | PR domain zinc finger protein 4 | 著者 | Amaya, M.F, Zeng, H, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2008-05-30 | 公開日 | 2008-08-12 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The crystal structure of methyltransferase domain of human PR domain-containing protein 4. To be Published
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3DAL
| Methyltransferase domain of human PR domain-containing protein 1 | 分子名称: | PR domain zinc finger protein 1 | 著者 | Amaya, M.F, Zeng, H, Antoshenko, T, Dong, A, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2008-05-29 | 公開日 | 2008-08-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The crystal structure
of methyltransferase domain of human PR domain-containing protein 1 To be Published
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7SEK
| Solution structure of the zinc finger domain of murine MetAP1, complexed with ZNG N-terminal peptide | 分子名称: | COBW domain-containing protein 1,Methionine aminopeptidase 1 fusion, ZINC ION | 著者 | Edmonds, K.A, Jordan, M.R, Thalluri, K, Wu, H, Di Marchi, R, Giedroc, D.P. | 登録日 | 2021-09-30 | 公開日 | 2022-06-01 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Cell, 185, 2022
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5HEC
| CgT structure in dimer | 分子名称: | Putative glycosyltransferase (GalT1) | 著者 | Zhang, H, Wu, H. | 登録日 | 2016-01-05 | 公開日 | 2016-08-31 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.395 Å) | 主引用文献 | New Helical Binding Domain Mediates a Glycosyltransferase Activity of a Bifunctional Protein. J.Biol.Chem., 291, 2016
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1SO8
| Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)] | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type II, CHLORIDE ION, SODIUM ION | 著者 | Lustbader, J.W, Cirilli, M, Wu, H. | 登録日 | 2004-03-13 | 公開日 | 2004-05-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science, 304, 2004
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3M0A
| Crystal structure of TRAF2:cIAP2 complex | 分子名称: | Baculoviral IAP repeat-containing protein 3, TNF receptor-associated factor 2, ZINC ION | 著者 | Kabaleeswaran, V, Wu, H. | 登録日 | 2010-03-02 | 公開日 | 2010-04-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Mol.Cell, 38, 2010
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4WUW
| Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D) Complexed with Inositol | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, CALCIUM ION, Pulmonary surfactant-associated protein A | 著者 | Rynkiewicz, M.J, Wu, H, Cafarella, T.R, Nikolaidis, N.M, Head, J.F, Seaton, B.A, McCormack, F.X. | 登録日 | 2014-11-03 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | 主引用文献 | Differential ligand binding specificities of the pulmonary collectins are determined by the conformational freedom of a surface loop To be published
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3MEK
| Crystal Structure of Human Histone-Lysine N-methyltransferase SMYD3 in Complex with S-adenosyl-L-methionine | 分子名称: | S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ZINC ION | 著者 | Lam, R, Dombrovski, L, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-03-31 | 公開日 | 2010-04-14 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of Human Histone-Lysine N-methyltransferase SMYD3 in Complex with S-adenosyl-L-methionine To be Published
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4WRF
| Crystal Structure of Surfactant Protein-A DEDN Mutant (E171D/P175E/R197N/K203D) Complexed with Mannose | 分子名称: | CALCIUM ION, CHLORIDE ION, HEXANE-1,6-DIOL, ... | 著者 | Rynkiewicz, M.J, Wu, H, Cafarella, T.R, Nikolaidis, N.M, Head, J.F, Seaton, B.A, McCormack, F.X. | 登録日 | 2014-10-23 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Differential ligand binding specificities of the pulmonary collectins are determined by the conformational freedom of a surface loop To be published
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4WR9
| Crystal Structure of Surfactant Protein-A DED Mutant (E171D/P175E/K203D) | 分子名称: | CALCIUM ION, Pulmonary surfactant-associated protein A | 著者 | Rynkiewicz, M.J, Wu, H, Cafarella, T.R, Nikolaidis, N.M, Head, J.F, Seaton, B.A, McCormack, F.X. | 登録日 | 2014-10-23 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Differential ligand binding specificities of the pulmonary collectins are determined by the conformational freedom of a surface loop To be published
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4WRC
| Crystal Structure of Surfactant Protein-A DEDN Mutant (E171D/P175E/R197N/K203D) | 分子名称: | CALCIUM ION, CHLORIDE ION, HEXANE-1,6-DIOL, ... | 著者 | Rynkiewicz, M.J, Wu, H, Cafarella, T.R, Nikolaidis, N.M, Head, J.F, Seaton, B.A, McCormack, F.X. | 登録日 | 2014-10-23 | 公開日 | 2016-02-10 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Differential ligand binding specificities of the pulmonary collectins are determined by the conformational freedom of a surface loop to be published
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3MOP
| The ternary Death Domain complex of MyD88, IRAK4, and IRAK2 | 分子名称: | Interleukin-1 receptor-associated kinase 4, Interleukin-1 receptor-associated kinase-like 2, Myeloid differentiation primary response protein MyD88 | 著者 | Lin, S.-C, Lo, Y.-C, Wu, H. | 登録日 | 2010-04-23 | 公開日 | 2010-06-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature, 465, 2010
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5Z8I
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4KFP
| Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | 分子名称: | 1,2-ETHANEDIOL, N-(4-{[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]sulfonyl}benzyl)-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Dragovich, P.S, Bair, K.W, Baumeister, T, Ho, Y, Liederer, B.M, Liu, X, O'Brien, T, Oeh, J, Sampath, D, Skelton, N, Wang, L, Wang, W, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X. | 登録日 | 2013-04-27 | 公開日 | 2013-08-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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4W6Q
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4U97
| Crystal Structure of Asymmetric IRAK4 Dimer | 分子名称: | Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION | 著者 | Ferrao, R, Wu, H. | 登録日 | 2014-08-05 | 公開日 | 2014-09-24 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly. Mol.Cell, 55, 2014
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4U9A
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