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Schmallenberg virus nucleoprotein-RNA complex
分子名称:	Nucleocapsid protein, RNA (42-MER)
著者	Dong, H.H, Li, P, Bottcher, B, Elliott, R.M, Dong, C.J.
登録日	2013-03-15
公開日	2013-07-31
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.12 Å)
主引用文献	Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism. Rna, 19, 2013

7F09

Crystal structure of the HLH-Lz domain of human TFE3
分子名称:	1,2-ETHANEDIOL, Transcription factor E3, ZINC ION
著者	Yang, G, Li, P, Liu, Z, Wu, S, Zhuang, C, Qiao, H, Fang, P, Wang, J.
登録日	2021-06-03
公開日	2021-07-21
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Structural basis for the dimerization mechanism of human transcription factor E3. Biochem.Biophys.Res.Commun., 569, 2021

2AYN

Structure of USP14, a proteasome-associated deubiquitinating enzyme
分子名称:	Ubiquitin carboxyl-terminal hydrolase 14
著者	Hu, M, Li, P, Jeffrey, P.D, Shi, Y.
登録日	2005-09-07
公開日	2005-10-18
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. Embo J., 24, 2005

2AYO

Structure of USP14 bound to ubquitin aldehyde
分子名称:	Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 14
著者	Hu, M, Li, P, Jeffrey, P.D, Shi, Y.
登録日	2005-09-07
公開日	2005-10-18
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (3.5 Å)
主引用文献	Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. Embo J., 24, 2005

7WQY

Crystal structure of grass carp ARF1-GDP complex
分子名称:	ARF1, GUANOSINE-5'-DIPHOSPHATE
著者	Ouyang, S, Chang, M, Li, P.
登録日	2022-01-26
公開日	2023-03-01
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Crystal structure of grass carp ARF1 To Be Published

7W3S

The complex structure of Larg1-ADPr from Legionella pneumophila
分子名称:	Type IV secretion protein Dot, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
著者	Ouyang, S, Guan, H, Li, P.
登録日	2021-11-26
公開日	2022-04-06
最終更新日	2022-05-18
実験手法	X-RAY DIFFRACTION (2.324 Å)
主引用文献	Legionella pneumophila temporally regulates the activity of ADP/ATP translocases by reversible ADP-ribosylation. mLife, 2022

5KEV

Vibrio parahaemolyticus VtrA/VtrC complex
分子名称:	SULFATE ION, VtrA Protein, VtrC Protein
著者	Tomchick, D.R, Orth, K, Rivera-Cancel, G.
登録日	2016-06-10
公開日	2016-07-20
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	Bile salt receptor complex activates a pathogenic type III secretion system. Elife, 5, 2016

5KEW

Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt taurodeoxycholate
分子名称:	1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ...
著者	Tomchick, D.R, Orth, K, Rivera-Cancel, G.
登録日	2016-06-10
公開日	2016-07-20
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (2.103 Å)
主引用文献	Bile salt receptor complex activates a pathogenic type III secretion system. Elife, 5, 2016

5B25

Crystal structure of human PDE1B with inhibitor 3
分子名称:	(11R,15S)-4-{[4-(6-fluoropyridin-2-yl)phenyl]methyl}-8-methyl-5-(phenylamino)-1,3,4,8,10-pentaazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, GLYCEROL, ...
著者	Ida, K, Lane, W, Snell, G, Sogabe, S.
登録日	2016-01-07
公開日	2016-02-03
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases J.Med.Chem., 59, 2016

6KZ5

Crystal Structure Analysis of the Csn-B-bounded NUR77 Ligand binding Domain
分子名称:	Nuclear receptor subfamily 4 group A member 1, ethyl 2-[2-octanoyl-3,5-bis(oxidanyl)phenyl]ethanoate
著者	Hong, W, Chen, H, Wu, Q, Lin, T.
登録日	2019-09-23
公開日	2020-10-14
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (4.45 Å)
主引用文献	Blocking PPAR gamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. Proc.Natl.Acad.Sci.USA, 117, 2020

6WO6

Structure of RavA (lpp0008) E38A/K39A surface entropy reduction mutant
分子名称:	RavA
著者	Cygler, M, Chung, I.Y.W.
登録日	2020-04-24
公開日	2021-03-17
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Structural and functional study of Legionella pneumophila effector RavA. Protein Sci., 30, 2021

3KY9

Autoinhibited Vav1
分子名称:	Proto-oncogene vav, ZINC ION
著者	Tomchick, D.R, Rosen, M.K, Machius, M, Yu, B.
登録日	2009-12-04
公開日	2010-02-23
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.731 Å)
主引用文献	Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1 Cell(Cambridge,Mass.), 140, 2010

5JAN

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	1,3-dimethyl-6-(2-methylpropoxy)pyrimidine-2,4(1H,3H)-dione, CALCIUM ION, CHLORIDE ION, ...
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.12 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAT

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	3-{2-[(2',6-dimethyl[1,1'-biphenyl]-3-yl)amino]-1,3-thiazol-4-yl}propan-1-ol, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.04 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAU

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	(2S)-3-(3-{[4-(2-aminoethoxy)-2',6-dimethyl[1,1'-biphenyl]-3-yl]amino}-1H-pyrazol-1-yl)-2-methoxypropan-1-ol, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAR

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	(2',6-dimethyl[1,1'-biphenyl]-3-yl)(1,3-thiazol-2-yl)methanone, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.11 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAL

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	(2,5-dihydro-1H-pyrrol-1-yl)(3-fluorophenyl)methanone, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAS

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	CHLORIDE ION, DIMETHYL SULFOXIDE, N-(2',6-dimethyl[1,1'-biphenyl]-3-yl)-1,3-thiazol-2-amine, ...
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAD

Compound binding to Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)discovered through fragment screening
分子名称:	CHLORIDE ION, DIMETHYL SULFOXIDE, MAGNESIUM ION, ...
著者	Day, P.J, Woolford, A.J.-A.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.05 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAH

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	1,5,5-trimethylimidazolidine-2,4-dione, CHLORIDE ION, Platelet-activating factor acetylhydrolase
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAP

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	(2,5-dihydro-1H-pyrrol-1-yl)(2',6-dimethyl[1,1'-biphenyl]-3-yl)methanone, CALCIUM ION, CHLORIDE ION, ...
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.46 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

5JAO

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) Discovered Through X-Ray Fragment Screening
分子名称:	2'-chloro-6-methyl[1,1'-biphenyl]-3-amine, CALCIUM ION, CHLORIDE ION, ...
著者	Day, P.J.
登録日	2016-04-12
公開日	2016-05-25
最終更新日	2024-05-08
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J.Med.Chem., 59, 2016

4F2L

Structure of a regulatory domain of AMPK
分子名称:	5'-AMP-activated protein kinase catalytic subunit alpha-1, MAGNESIUM ION
著者	Xin, F.J, Zhang, Y.Y, Wang, J, Wang, Z.X, Wu, J.W.
登録日	2012-05-08
公開日	2013-06-26
最終更新日	2017-11-15
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Conserved regulatory elements in AMPK Nature, 498, 2013

5S9R

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH BMS-986158, 2-{3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-7-yl}propan-2-ol
分子名称:	1,2-ETHANEDIOL, 2-{3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-[(S)-(oxan-4-yl)(phenyl)methyl]-5H-pyrido[3,2-b]indol-7-yl}propan-2-ol, Bromodomain-containing protein 4, ...
著者	Sheriff, S.
登録日	2021-04-01
公開日	2021-09-29
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design. J.Med.Chem., 64, 2021

5S9P

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 9-benzyl-2-(3,5-dimethyl-1,2-oxazol-4-yl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-4-carboxamide
分子名称:	1,2-ETHANEDIOL, 9-benzyl-2-(3,5-dimethyl-1,2-oxazol-4-yl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-4-carboxamide, Bromodomain-containing protein 4
著者	Sheriff, S.
登録日	2021-04-01
公開日	2021-09-29
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design. J.Med.Chem., 64, 2021

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