7Y64
 
 | | Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | | 分子名称: | C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | 登録日 | 2022-06-18 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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7Y65
 | | Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein | | 分子名称: | C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | 登録日 | 2022-06-18 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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7Y66
 | | Cryo-EM structure of BM213-bound C5aR1 in complex with Gi protein | | 分子名称: | BM213 peptide, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | 登録日 | 2022-06-18 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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7Y56
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7Y57
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8JZ7
 | | Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein | | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H. | | 登録日 | 2023-07-04 | | 公開日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2.
Signal Transduct Target Ther, 8, 2023
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4WD5
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5VGO
 | | Bruton's tyrosine kinase (BTK) with compound G-744 | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-[2-(hydroxymethyl)-3-{1-methyl-6-oxo-5-[(pyrimidin-4-yl)amino]-1,6-dihydropyridin-3-yl}phenyl]-6,6-dimethyl-3,4,6,7-tetrahydro-2H-cyclopenta[4,5]thieno[2,3-c]pyridin-1(5H)-one, GLYCEROL, ... | | 著者 | Yu, C, Eigenbrot, C. | | 登録日 | 2017-04-11 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.621 Å) | | 主引用文献 | Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.
ACS Med Chem Lett, 8, 2017
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5VJS
 | | De Novo Photosynthetic Reaction Center Protein Equipped with Heme B, a synthetic Zn porphyrin, and Zn(II) cations | | 分子名称: | CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, Reaction Center Maquette, ... | | 著者 | Ennist, N.M, Dutton, P.L, Stayrook, S.E, Moser, C.C. | | 登録日 | 2017-04-19 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | De novo protein design of photochemical reaction centers.
Nat Commun, 13, 2022
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5VJU
 | | De Novo Photosynthetic Reaction Center Protein Variant Equipped with His-Tyr H-bond, Heme B, and Cd(II) ions | | 分子名称: | CADMIUM ION, PROTOPORPHYRIN IX CONTAINING FE, Reaction Center Maquette Leu71His variant | | 著者 | Ennist, N.M, Stayrook, S.E, Dutton, P.L, Moser, C.C. | | 登録日 | 2017-04-19 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | De novo protein design of photochemical reaction centers.
Nat Commun, 13, 2022
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3V5L
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8JLP
 | | Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex | | 分子名称: | 5-ethyl-4-methyl-~{N}-[4-[(2~{S})-morpholin-2-yl]phenyl]-1~{H}-pyrazole-3-carboxamide, Gs, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLK
 | | Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex | | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLQ
 | | Fenoldopam-bound hTAAR1-Gs protein complex | | 分子名称: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLN
 | | T1AM-bound hTAAR1-Gs protein complex | | 分子名称: | 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLO
 | | Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex | | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLJ
 | | T1AM-bound mTAAR1-Gs protein complex | | 分子名称: | 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JLR
 | | A77636-bound hTAAR1-Gs protein complex | | 分子名称: | (1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-02 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JSO
 | | AMPH-bound hTAAR1-Gs protein complex | | 分子名称: | (2S)-1-phenylpropan-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-20 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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8JSP
 | | Ulotaront(SEP-363856)-bound Serotonin 1A (5-HT1A) receptor-Gi complex | | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, 5-hydroxytryptamine receptor 1A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | | 登録日 | 2023-06-20 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-01-03 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
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7LGU
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7LGW
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7LH2
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7LH3
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5GUT
 | | The crystal structure of mouse DNMT1 (731-1602) mutant - N1248A | | 分子名称: | DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | | 著者 | Chen, S.J, Ye, F. | | 登録日 | 2016-08-31 | | 公開日 | 2017-09-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
ACS Chem. Biol., 13, 2018
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