5VGO

Bruton's tyrosine kinase (BTK) with compound G-744

Summary for 5VGO

• Entry DOI: 10.2210/pdb5vgo/pdb
• Related: 5VFI
• Descriptor: Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total)
• Functional Keywords: protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q06187
• Total number of polymer chains: 1
• Total formula weight: 32932.84

Authors

Yu, C.,Eigenbrot, C. (deposition date: 2017-04-11, release date: 2017-07-05, Last modification date: 2023-10-04)

• Primary citation: Wang, X.,Barbosa, J.,Blomgren, P.,Bremer, M.C.,Chen, J.,Crawford, J.J.,Deng, W.,Dong, L.,Eigenbrot, C.,Gallion, S.,Hau, J.,Hu, H.,Johnson, A.R.,Katewa, A.,Kropf, J.E.,Lee, S.H.,Liu, L.,Lubach, J.W.,Macaluso, J.,Maciejewski, P.,Mitchell, S.A.,Ortwine, D.F.,DiPaolo, J.,Reif, K.,Scheerens, H.,Schmitt, A.,Wong, H.,Xiong, J.M.,Xu, J.,Zhao, Z.,Zhou, F.,Currie, K.S.,Young, W.B.; Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.; ACS Med Chem Lett, 8:608-613, 2017; PubMed: 28626519; DOI: 10.1021/acsmedchemlett.7b00103

Experimental method

X-RAY DIFFRACTION (1.621 Å)