Summary for 5VGO
| Related | 5VFI |
|---|---|
| Descriptor | Tyrosine-protein kinase BTK, SULFATE ION, GLYCEROL, ... (6 entities in total) |
| Functional Keywords | protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm Q06187 |
| Total number of polymer chains | 1 |
| Total molecular weight | 32932.84 |
| Authors | |
| Primary citation | Wang, X.,Barbosa, J.,Blomgren, P.,Bremer, M.C.,Chen, J.,Crawford, J.J.,Deng, W.,Dong, L.,Eigenbrot, C.,Gallion, S.,Hau, J.,Hu, H.,Johnson, A.R.,Katewa, A.,Kropf, J.E.,Lee, S.H.,Liu, L.,Lubach, J.W.,Macaluso, J.,Maciejewski, P.,Mitchell, S.A.,Ortwine, D.F.,DiPaolo, J.,Reif, K.,Scheerens, H.,Schmitt, A.,Wong, H.,Xiong, J.M.,Xu, J.,Zhao, Z.,Zhou, F.,Currie, K.S.,Young, W.B. Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties. ACS Med Chem Lett, 8:608-613, 2017 PubMed: 28626519 (PDB entries with the same primary citation) DOI: 10.1021/acsmedchemlett.7b00103  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.621 Å) |
