5GVK
 
 | | Plasmodium vivax SHMT bound with PLP-glycine and GS256 | | 分子名称: | 5-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-cyano-phenyl]-~{N},~{N}-dimethyl-thiophene-2-sulfonamide, CHLORIDE ION, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], ... | | 著者 | Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U, Schwertz, G. | | 登録日 | 2016-09-06 | | 公開日 | 2017-07-12 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures
J. Med. Chem., 60, 2017
|
|
8OKH
 | |
5V2H
 | | RNA octamer containing glycol nucleic acid, SgnT | | 分子名称: | COBALT HEXAMMINE(III), MAGNESIUM ION, RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3') | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2017-03-04 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.080013 Å) | | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
|
|
4ZMJ
 | | Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Kwon, Y.D, Kwong, P.D. | | 登録日 | 2015-05-04 | | 公開日 | 2015-06-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.
Nat.Struct.Mol.Biol., 22, 2015
|
|
6CVZ
 | | Crystal structure of the WD40-repeat of RFWD3 | | 分子名称: | E3 ubiquitin-protein ligase RFWD3, MAGNESIUM ION | | 著者 | DONG, A, LOPPNAU, P, SEITOVA, A, HUTCHINSON, A, TEMPEL, W, WEI, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, TONG, Y, Structural Genomics Consortium (SGC) | | 登録日 | 2018-03-29 | | 公開日 | 2018-06-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Target highlights in CASP13: Experimental target structures through the eyes of their authors.
Proteins, 87, 2019
|
|
5V1K
 | | Structure of R-GNA dodecamer | | 分子名称: | RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3') | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2017-03-02 | | 公開日 | 2017-06-21 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
|
|
5V1L
 | | Structure of S-GNA dodecamer | | 分子名称: | RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), SPERMINE, STRONTIUM ION | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2017-03-02 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
|
|
6WEZ
 | | Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H3 Hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hemagglutinin, ... | | 著者 | Harshbarger, W.D, Lockbaum, G.J, Deming, D.T, Attatippaholkun, N, Schiffer, C.A, Marasco, W.A. | | 登録日 | 2020-04-03 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | | 主引用文献 | Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Nat Commun, 12, 2021
|
|
6WF0
 | | Crystal Structure of Broadly Neutralizing Antibody 3I14 Bound to the Influenza A H3 Hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Harshbarger, W.D, Lockbaum, G.J, Deming, D.T, Attatippaholkun, N, Schiffer, C.A, Marasco, W.A. | | 登録日 | 2020-04-03 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.46 Å) | | 主引用文献 | Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Nat Commun, 12, 2021
|
|
6WF1
 | | Crystal Structure of Broadly Neutralizing Antibody 3I14 Bound to the Influenza A H10 Hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Hemagglutinin HA2 chain, ... | | 著者 | Harshbarger, W.D, Lockbaum, G.J, Deming, D.T, Attatippaholkun, N, Schiffer, C.A, Marasco, W.A. | | 登録日 | 2020-04-03 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (4.19 Å) | | 主引用文献 | Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Nat Commun, 12, 2021
|
|
6VEM
 | | Structure of RNA octamer | | 分子名称: | COBALT HEXAMMINE(III), Modified Octamer RNA | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2020-01-02 | | 公開日 | 2020-11-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine.
Nucleic Acids Res., 48, 2020
|
|
6WEX
 | | Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H6 Hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Hemagglutinin HA2 chain, ... | | 著者 | Harshbarger, W.D, Lockbaum, G.J, Deming, D.T, Attatippaholkun, N, Schiffer, C.A, Marasco, W.A. | | 登録日 | 2020-04-03 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | | 主引用文献 | Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Nat Commun, 12, 2021
|
|
6XSK
 | | Cryo-EM Structure of Vaccine-Elicited Rhesus Antibody 789-203-3C12 in Complex with Stabilized SI06 (A/Solomon Islands/3/06) Influenza Hemagglutinin Trimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 789-203-3C12 Fab Heavy Chain, ... | | 著者 | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | | 登録日 | 2020-07-15 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | | 主引用文献 | Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
Immunity, 55, 2022
|
|
7AC0
 | |
2JN0
 | | Solution NMR structure of the ygdR protein from Escherichia coli. Northeast Structural Genomics target ER382A. | | 分子名称: | Hypothetical lipoprotein ygdR | | 著者 | Rossi, P, Chen, C.X, Jiang, M, Cunningham, K, Ma, L, Xiao, R, Liu, J.C, Baran, M, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2006-12-15 | | 公開日 | 2007-05-01 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR structure of the ygdR protein from Escherichia coli. Northeast Structural Genomics target ER382A.
To be Published
|
|
8THQ
 | | Nonamer RNA bound to hAgo2-PAZ | | 分子名称: | Protein argonaute-2, RNA (5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3') | | 著者 | Pallan, P.S, Harp, J.M, Egli, M. | | 登録日 | 2023-07-17 | | 公開日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway.
J.Am.Chem.Soc., 2024
|
|
1WV6
 | | X-ray structure of the A-decamer GCGTATACGC with a single 2'-O-butyl thymine in place of T6, Sr-form | | 分子名称: | 5'-D(*GP*CP*GP*TP*AP*(2BT)P*AP*CP*GP*C)-3', STRONTIUM ION | | 著者 | Egli, M, Minasov, G, Tereshko, V, Pallan, P.S, Teplova, M, Inamati, G.B, Lesnik, E.A, Owens, S.R, Ross, B.S, Prakash, T.P, Manoharam, M. | | 登録日 | 2004-12-11 | | 公開日 | 2005-06-28 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Biochemistry, 44, 2005
|
|
6CY2
 | | RNA octamer containing 2'-OMe, 4'Calpha-OMe U. | | 分子名称: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3') | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2018-04-04 | | 公開日 | 2018-08-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
|
|
6CXZ
 | | RNA octamer containing 2'-F, 4'-Calpha-Me U. | | 分子名称: | CACODYLATE ION, COBALT HEXAMMINE(III), RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3') | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2018-04-04 | | 公開日 | 2018-08-29 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
|
|
8VUE
 | | L5A7 Fab bound to Indonesia2005 Hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, ... | | 著者 | Olia, A.S, Gorman, J, Kwong, P.D. | | 登録日 | 2024-01-29 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.
Front Immunol, 15, 2024
|
|
8VUZ
 | | L5A7 Fab bound to 28H6E11 anti-idiotype Fab | | 分子名称: | 28H6E11 Fab Heavy Chain, 28H6E11 Fab Light Chain, L5A7 Fab Heavy Chain, ... | | 著者 | Olia, A.S, Morano, N.C, Kwong, P.D. | | 登録日 | 2024-01-30 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | | 主引用文献 | Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.
Front Immunol, 15, 2024
|
|
8VVB
 | | Influenza antibody L5A7 Fab | | 分子名称: | L5A7 Heavy Chain, L5A7 Light Chain | | 著者 | Harris, D.R, Olia, A.S, Kwong, P.D. | | 登録日 | 2024-01-30 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.
Front Immunol, 15, 2024
|
|
6CP8
 | | Contact-dependent growth inhibition toxin-immunity protein complex from from E. coli 3006 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CdiA, CdiI, ... | | 著者 | Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI) | | 登録日 | 2018-03-13 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | | 主引用文献 | Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.
Structure, 27, 2019
|
|
6CP9
 | | Contact-dependent growth inhibition toxin - immunity protein complex from Klebsiella pneumoniae 342 | | 分子名称: | CdiA, CdiI | | 著者 | Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI) | | 登録日 | 2018-03-13 | | 公開日 | 2019-03-13 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.
Structure, 27, 2019
|
|
6CY0
 | | RNA octamer containing 2'-F, 4'-Cbeta-OMe U. | | 分子名称: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3') | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2018-04-04 | | 公開日 | 2018-08-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.398 Å) | | 主引用文献 | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
|
|
