8OKH

Crystal structure of Bdellovibrio bacteriovorus Bd1399

Summary for 8OKH

• Entry DOI: 10.2210/pdb8okh/pdb
• Descriptor: DUF2807 domain-containing protein, GLYCEROL, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: unknown function
• Biological source: Bdellovibrio bacteriovorus HD100
• Total number of polymer chains: 2
• Total formula weight: 38259.24

Authors

Caulton, S.G.,Lovering, A.L. (deposition date: 2023-03-28, release date: 2023-10-25, Last modification date: 2024-11-20)

Primary citation

Alexander, L.T.,Durairaj, J.,Kryshtafovych, A.,Abriata, L.A.,Bayo, Y.,Bhabha, G.,Breyton, C.,Caulton, S.G.,Chen, J.,Degroux, S.,Ekiert, D.C.,Erlandsen, B.S.,Freddolino, P.L.,Gilzer, D.,Greening, C.,Grimes, J.M.,Grinter, R.,Gurusaran, M.,Hartmann, M.D.,Hitchman, C.J.,Keown, J.R.,Kropp, A.,Kursula, P.,Lovering, A.L.,Lemaitre, B.,Lia, A.,Liu, S.,Logotheti, M.,Lu, S.,Markusson, S.,Miller, M.D.,Minasov, G.,Niemann, H.H.,Opazo, F.,Phillips Jr., G.N.,Davies, O.R.,Rommelaere, S.,Rosas-Lemus, M.,Roversi, P.,Satchell, K.,Smith, N.,Wilson, M.A.,Wu, K.L.,Xia, X.,Xiao, H.,Zhang, W.,Zhou, Z.H.,Fidelis, K.,Topf, M.,Moult, J.,Schwede, T.
Protein target highlights in CASP15: Analysis of models by structure providers.
Proteins, 91:1571-1599, 2023

PubMed Abstract: We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.

PubMed: 37493353
DOI: 10.1002/prot.26545

Experimental method

X-RAY DIFFRACTION (2.17 Å)