3SOA
 
 | | Full-length human CaMKII | | 分子名称: | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Calcium/calmodulin-dependent protein kinase type II subunit alpha with a beta 7 linker | | 著者 | Chao, L.H, Kuriyan, J. | | 登録日 | 2011-06-30 | | 公開日 | 2011-08-31 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.5501 Å) | | 主引用文献 | A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme.
Cell(Cambridge,Mass.), 146, 2011
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3ET6
 | | The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase | | 分子名称: | PHOSPHATE ION, Soluble guanylyl cyclase beta | | 著者 | Winger, J.A, Derbyshire, E.R, Lamers, M.H, Marletta, M.A, Kuriyan, J. | | 登録日 | 2008-10-07 | | 公開日 | 2008-10-14 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.
Bmc Struct.Biol., 8, 2008
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3FW1
 | | Quinone Reductase 2 | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Winger, J.A, Hantschel, O, Superti-Furga, G, Kuriyan, J. | | 登録日 | 2009-01-16 | | 公開日 | 2009-03-10 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
Bmc Struct.Biol., 9, 2009
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1X11
 | | X11 PTB DOMAIN | | 分子名称: | 13-MER PEPTIDE, X11 | | 著者 | Lee, C.-H, Zhang, Z, Kuriyan, J. | | 登録日 | 1997-07-28 | | 公開日 | 1998-01-14 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.
EMBO J., 16, 1997
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3F6X
 | | c-Src kinase domain in complex with small molecule inhibitor | | 分子名称: | Proto-oncogene tyrosine-protein kinase Src, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile | | 著者 | Seeliger, M.A, Statsuk, A.V, Maly, D.J, Patrick, P.Z, Kuriyan, J, Shokat, K.M. | | 登録日 | 2008-11-06 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Tuning a three-component reaction for trapping kinase substrate complexes.
J.Am.Chem.Soc., 130, 2008
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3DQW
 | | c-Src kinase domain Thr338Ile mutant in complex with ATPgS | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | | 登録日 | 2008-07-09 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.017 Å) | | 主引用文献 | Activation of tyrosine kinases by mutation of the gatekeeper threonine.
Nat.Struct.Mol.Biol., 15, 2008
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3G6H
 | | Src Thr338Ile inhibited in the DFG-Asp-Out conformation | | 分子名称: | N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J. | | 登録日 | 2009-02-06 | | 公開日 | 2009-03-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
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3DQX
 | | chicken c-Src kinase domain in complex with ATPgS | | 分子名称: | ADENOSINE MONOPHOSPHATE, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | | 登録日 | 2008-07-09 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Activation of tyrosine kinases by mutation of the gatekeeper threonine.
Nat.Struct.Mol.Biol., 15, 2008
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3GLG
 | | Crystal Structure of a Mutant (gammaT157A) E. coli Clamp Loader Bound to Primer-Template DNA | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ... | | 著者 | Simonetta, K.R, Seyedin, S.N, Kuriyan, J. | | 登録日 | 2009-03-12 | | 公開日 | 2009-05-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
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3GLF
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3GT8
 | | Crystal structure of the inactive EGFR kinase domain in complex with AMP-PNP | | 分子名称: | Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Jura, N, Endres, N.F, Engel, K, Deindl, S, Das, R, Lamers, M.H, Wemmer, D.E, Zhang, X, Kuriyan, J. | | 登録日 | 2009-03-27 | | 公開日 | 2009-07-21 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.955 Å) | | 主引用文献 | Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment.
Cell(Cambridge,Mass.), 137, 2009
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3G6G
 | | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations | | 分子名称: | GLYCEROL, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J. | | 登録日 | 2009-02-06 | | 公開日 | 2009-03-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
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3EEE
 | | Probing the function of heme distortion in the H-NOX family | | 分子名称: | CHLORIDE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | | 著者 | Olea Jr, C, Boon, E.M, Pellicena, P, Kuriyan, J, Marletta, M.A. | | 登録日 | 2008-09-04 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Probing the function of heme distortion in the H-NOX family.
Acs Chem.Biol., 3, 2008
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3GLI
 | | Crystal Structure of the E. coli clamp loader bound to Primer-Template DNA and Psi Peptide | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (5'-D(*CP*TP*GP*GP*CP*CP*TP*AP*TP*A)-3'), ... | | 著者 | Simonetta, K.R, Cantor, A.J, Kuriyan, J. | | 登録日 | 2009-03-12 | | 公開日 | 2009-05-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
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3GLH
 | | Crystal Structure of the E. coli clamp loader bound to Psi Peptide | | 分子名称: | DNA polymerase III subunit delta, DNA polymerase III subunit delta', DNA polymerase III subunit tau | | 著者 | Kazmirski, S.L, Simonetta, K.R, Kuriyan, J. | | 登録日 | 2009-03-12 | | 公開日 | 2009-05-26 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.891 Å) | | 主引用文献 | The mechanism of ATP-dependent primer-template recognition by a clamp loader complex.
Cell(Cambridge,Mass.), 137, 2009
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3TF1
 | | Crystal structure of an H-NOX protein from T. tengcongensis under 6 atm of xenon | | 分子名称: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.0369 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFF
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L67W mutant | | 分子名称: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9401 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF0
 | | Crystal structure of an H-NOX protein from T. tengcongensis | | 分子名称: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.743 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFE
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant under 6 atm of xenon | | 分子名称: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.991 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFD
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant | | 分子名称: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFG
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W/L67W double mutant | | 分子名称: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9003 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFA
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 6 atm of xenon | | 分子名称: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, XENON | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2711 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF8
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 | | 分子名称: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1302 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF9
 | | Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 1 atm of xenon | | 分子名称: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ... | | 著者 | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2011-08-15 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5901 Å) | | 主引用文献 | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3U5Z
 | | Structure of T4 Bacteriophage clamp loader bound to the T4 clamp, primer-template DNA, and ATP analog | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase accessory protein 44, DNA polymerase accessory protein 62, ... | | 著者 | Kelch, B.A, Makino, D.L, O'Donnell, M, Kuriyan, J. | | 登録日 | 2011-10-11 | | 公開日 | 2012-01-04 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | How a DNA polymerase clamp loader opens a sliding clamp.
Science, 334, 2011
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