5Z36
 
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3T4H
 | | Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(3-nitrobenzyl)-L-cysteine | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, ... | | 著者 | Ma, J, Aik, W.S, McDonough, M.A, Schofield, C.J. | | 登録日 | 2011-07-26 | | 公開日 | 2012-03-07 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase.
J.Med.Chem., 55, 2012
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5Z8O
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7XBZ
 | | Crystal structure of Staphylococcus aureus ClpP in complex with R-ZG197 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (6S,9aS)-6-[(2S)-butan-2-yl]-8-[(1R)-1-naphthalen-1-ylethyl]-4,7-bis(oxidanylidene)-N-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit, ... | | 著者 | Wei, B.Y, Gan, J.H, Yang, C.-G. | | 登録日 | 2022-03-22 | | 公開日 | 2022-11-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP.
Nat Commun, 13, 2022
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7CE2
 | | The Crystal structure of TeNT Hc complexed with neutralizing antibody | | 分子名称: | Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain | | 著者 | Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H. | | 登録日 | 2020-06-21 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Structural basis of tetanus toxin neutralization by native human monoclonal antibodies.
Cell Rep, 35, 2021
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8CVN
 | | Cryo-EM Structure of Human 15-PGDH in Complex with Small Molecule SW209415 | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 2-[butyl(oxidanyl)-$l^{3}-sulfanyl]-4-(2,3-dimethylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine | | 著者 | Huang, W, Taylor, D.J. | | 登録日 | 2022-05-18 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.
Nat Commun, 14, 2023
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8CWL
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7CQP
 | | Complex of TRPC4 and Calmodulin_Nlobe | | 分子名称: | CALCIUM ION, Calmodulin-1, Peptide from Short transient receptor potential channel 4 | | 著者 | Shen, Z.S. | | 登録日 | 2020-08-11 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Calmodulin binds to Drosophila TRP with an unexpected mode.
Structure, 29, 2021
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7CQH
 | | Complex of TRP_CBS2 and Calmodulin_Clobe | | 分子名称: | AT15141p, CALCIUM ION, Transient receptor potential protein | | 著者 | Shen, Z.S. | | 登録日 | 2020-08-10 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Calmodulin binds to Drosophila TRP with an unexpected mode.
Structure, 29, 2021
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7CQV
 | | Complex of TRP_CBS1 and Calmodulin_Nlobe | | 分子名称: | AT15141p, CALCIUM ION, Transient receptor potential protein | | 著者 | Shen, Z.S. | | 登録日 | 2020-08-11 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Calmodulin binds to Drosophila TRP with an unexpected mode.
Structure, 29, 2021
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2LY3
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2JBV
 | | Crystal structure of choline oxidase reveals insights into the catalytic mechanism | | 分子名称: | CHOLINE OXIDASE, DIMETHYL SULFOXIDE, UNKNOWN ATOM OR ION, ... | | 著者 | Lountos, G.T, Fan, F, Gadda, G, Orville, A.M. | | 登録日 | 2006-12-13 | | 公開日 | 2007-12-25 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Role of Glu312 in Binding and Positioning of the Substrate for the Hydride Transfer Reaction in Choline Oxidase.
Biochemistry, 47, 2008
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7MU6
 | | Ask1 bound to compound 28 | | 分子名称: | 2-methoxy-N-(6-{4-[(2S)-1,1,1-trifluoropropan-2-yl]-4H-1,2,4-triazol-3-yl}pyridin-2-yl)pyridine-3-carboxamide, Mitogen-activated protein kinase kinase kinase 5 | | 著者 | Chodaparambil, J.V, Marcotte, D.J. | | 登録日 | 2021-05-14 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.165 Å) | | 主引用文献 | Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.
J.Med.Chem., 64, 2021
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5NX7
 | | Crystal structure of 1,8-cineole synthase from Streptomyces clavuligerus in complex with 2-fluoroneryl diphosphate and 2-fluorogeranyl diphosphate | | 分子名称: | (2E)-2-fluoro-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate, (2Z)-2-fluoro-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate, 2-ethyl-2-(hydroxymethyl)propane-1,3-diol, ... | | 著者 | Karuppiah, V, Leys, D, Scrutton, N.S. | | 登録日 | 2017-05-09 | | 公開日 | 2017-09-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.
ACS Catal, 7, 2017
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3Q8T
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2Q2O
 | | Crystal structure of H183C Bacillus subtilis ferrochelatase in complex with deuteroporphyrin IX 2,4-disulfonic acid dihydrochloride | | 分子名称: | Ferrochelatase, MAGNESIUM ION, PROTOPORPHYRIN IX 2,4-DISULFONIC ACID | | 著者 | Karlberg, T, Thorvaldsen, O.H, Al-Karadaghi, S. | | 登録日 | 2007-05-29 | | 公開日 | 2008-06-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Porphyrin binding and distortion and substrate specificity in the ferrochelatase reaction: the role of active site residues
J.Mol.Biol., 378, 2008
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2Q3J
 | | Crystal structure of the His183Ala variant of Bacillus subtilis ferrochelatase in complex with N-Methyl Mesoporphyrin | | 分子名称: | Ferrochelatase, MAGNESIUM ION, N-METHYL PROTOPORPHYRIN IX 2,4-DISULFONIC ACID | | 著者 | Karlberg, T, Thorvaldsen, O.H, Al-Karadaghi, S. | | 登録日 | 2007-05-30 | | 公開日 | 2008-04-22 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Porphyrin binding and distortion and substrate specificity in the ferrochelatase reaction: the role of active site residues
J.Mol.Biol., 378, 2008
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3T4V
 | | Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(2-napthalenemethyl)-L-cysteine | | 分子名称: | Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, GLYCEROL, ... | | 著者 | Aik, W.S, McDonough, M.A, Schofield, C.J. | | 登録日 | 2011-07-26 | | 公開日 | 2012-03-07 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.732 Å) | | 主引用文献 | Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase.
J.Med.Chem., 55, 2012
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7EKI
 | | human alpha 7 nicotinic acetylcholine receptor in apo-form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | 著者 | Liu, S, Zhao, Y, Sun, D, Tian, C. | | 登録日 | 2021-04-05 | | 公開日 | 2021-05-19 | | 最終更新日 | 2021-06-16 | | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | | 主引用文献 | Structural basis of human alpha 7 nicotinic acetylcholine receptor activation.
Cell Res., 31, 2021
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7EKP
 | | human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, ... | | 著者 | Liu, S, Zhao, Y, Sun, D, Tian, C. | | 登録日 | 2021-04-06 | | 公開日 | 2021-05-19 | | 最終更新日 | 2021-06-16 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural basis of human alpha 7 nicotinic acetylcholine receptor activation.
Cell Res., 31, 2021
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7EKT
 | | human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, ... | | 著者 | Liu, S, Zhao, Y, Sun, D, Tian, C. | | 登録日 | 2021-04-06 | | 公開日 | 2021-05-19 | | 最終更新日 | 2021-06-16 | | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | | 主引用文献 | Structural basis of human alpha 7 nicotinic acetylcholine receptor activation.
Cell Res., 31, 2021
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7ZCS
 | | Nitrite-bound MSOX movie series dataset 65 (52 MGy) of the copper nitrite reductase from Bradyrhizobium sp. ORS 375 (two-domain) - water ligand (final) | | 分子名称: | COPPER (II) ION, Copper-containing nitrite reductase, GLYCEROL, ... | | 著者 | Rose, S.L, Baba, S, Okumura, H, Antonyuk, S.V, Sasaki, D, Tosha, T, Kumasaka, T, Eady, R.R, Yamamoto, M, Hasnain, S.S. | | 登録日 | 2022-03-28 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7ZCP
 | | Nitrite-bound MSOX movie series dataset 17 (13.6 MGy) of the copper nitrite reductase from Bradyrhizobium sp. ORS 375 (two-domain) - nitric oxide (NO) intermediate | | 分子名称: | COPPER (II) ION, Copper-containing nitrite reductase, GLYCEROL, ... | | 著者 | Rose, S.L, Baba, S, Okumura, H, Antonyuk, S.V, Sasaki, D, Tosha, T, Kumasaka, T, Eady, R.R, Yamamoto, M, Hasnain, S.S. | | 登録日 | 2022-03-28 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7ZCR
 | | Nitrite-bound MSOX movie series dataset 38 (30.4 MGy) of the copper nitrite reductase from Bradyrhizobium sp. ORS 375 (two-domain) - water ligand | | 分子名称: | COPPER (II) ION, Copper-containing nitrite reductase, GLYCEROL, ... | | 著者 | Rose, S.L, Baba, S, Okumura, H, Antonyuk, S.V, Sasaki, D, Tosha, T, Kumasaka, T, Eady, R.R, Yamamoto, M, Hasnain, S.S. | | 登録日 | 2022-03-28 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7ZCO
 | | Nitrite-bound MSOX movie series dataset 8 (6.4 MGy) of the copper nitrite reductase from Bradyrhizobium sp. ORS 375 (two-domain) - nitrite/NO intermediate | | 分子名称: | COPPER (II) ION, Copper-containing nitrite reductase, GLYCEROL, ... | | 著者 | Rose, S.L, Baba, S, Okumura, H, Antonyuk, S.V, Sasaki, D, Tosha, T, Kumasaka, T, Eady, R.R, Yamamoto, M, Hasnain, S.S. | | 登録日 | 2022-03-28 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases.
Proc.Natl.Acad.Sci.USA, 119, 2022
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