2JBV

Crystal structure of choline oxidase reveals insights into the catalytic mechanism

Summary for 2JBV

• Entry DOI: 10.2210/pdb2jbv/pdb
• Descriptor: CHOLINE OXIDASE, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(4aS,10aR)-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: alcohol oxidation, flavoenyzme oxidase, covalently linked fad, arthrobacter globiformis, c4a-adduct, flavoprotein, oxidoreductase, glucose-methanol-choline oxidoreductase enzyme superfamily
• Biological source: ARTHROBACTER GLOBIFORMIS
• Total number of polymer chains: 2
• Total formula weight: 121532.94

Authors

Lountos, G.T.,Fan, F.,Gadda, G.,Orville, A.M. (deposition date: 2006-12-13, release date: 2007-12-25, Last modification date: 2023-12-13)

• Primary citation: Quaye, O.,Lountos, G.T.,Fan, F.,Orville, A.M.,Gadda, G.; Role of Glu312 in Binding and Positioning of the Substrate for the Hydride Transfer Reaction in Choline Oxidase.; Biochemistry, 47:243-, 2008; PubMed: 18072756; DOI: 10.1021/BI7017943

Experimental method

X-RAY DIFFRACTION (1.86 Å)