6Q0S
 
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2K9R
 | | Enhancing the activity of insulin by stereospecific unfolding | | 分子名称: | Insulin | | 著者 | Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2008-10-23 | | 公開日 | 2008-11-11 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
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4JO1
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2K91
 | | Enhancing the activity of insulin by stereospecific unfolding | | 分子名称: | Insulin | | 著者 | Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2008-09-29 | | 公開日 | 2008-11-18 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
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8T87
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4JO4
 | | Crystal structure of rabbit mAb R20 Fab | | 分子名称: | PENTAETHYLENE GLYCOL, SULFATE ION, monoclonal anti-HIV-1 gp120 V3 antibody R20 heavy chain, ... | | 著者 | Pan, R.M, Kong, X.P. | | 登録日 | 2013-03-16 | | 公開日 | 2013-07-31 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Rabbit Anti-HIV-1 Monoclonal Antibodies Raised by Immunization Can Mimic the Antigen-Binding Modes of Antibodies Derived from HIV-1-Infected Humans.
J.Virol., 87, 2013
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7T63
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6TOJ
 | | Crystal structure of human BCL6 BTB domain in complex with compound 17a | | 分子名称: | 1,2-ETHANEDIOL, 2-chloranyl-4-[[1-methyl-3-(3-methyl-3-oxidanyl-butyl)-2-oxidanylidene-benzimidazol-5-yl]amino]pyridine-3-carbonitrile, B-cell lymphoma 6 protein | | 著者 | Rodrigues, M.J, Le Bihan, Y.-V, van Montfort, R.L.M. | | 登録日 | 2019-12-11 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | AchievingIn VivoTarget Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
J.Med.Chem., 63, 2020
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8T88
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4JL7
 | | Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1 | | 分子名称: | CHLORIDE ION, Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | | 著者 | Lu, G, Wu, Y, Jiang, Y, Brunzelle, J, Sirinupong, N, Li, C, Yang, Z. | | 登録日 | 2013-03-12 | | 公開日 | 2013-10-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1.
Plos One, 8, 2013
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7JZI
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7JZ4
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7JZK
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7JZ1
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4CHK
 | | Crystal Structure of the ARF5 oligomerization domain | | 分子名称: | AUXIN RESPONSE FACTOR 5 | | 著者 | Nanao, M.H, Mazzoleni, M, Thevenon, E, Brunoud, G, Vernoux, T, Parcy, F, Dumas, R. | | 登録日 | 2013-12-03 | | 公開日 | 2014-04-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural Basis for Oligomerisation of Auxin Transcriptional Regulators
Nat.Commun., 5, 2014
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5HA9
 | | Crystal structure-based design and disovery of a novel PARP1 antiagonist (BL-PA10) that induces apoptosis and inhibits metastasis in triple negative breast cancer | | 分子名称: | Amitriptyline, GLYCEROL, Poly [ADP-ribose] polymerase 1, ... | | 著者 | Fu, L, Peng, H, Zhang, L, Ouyang, L. | | 登録日 | 2015-12-30 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (4.01 Å) | | 主引用文献 | Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer.
Sci Rep, 6, 2016
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7MTD
 | | Structure of aged SARS-CoV-2 S2P spike at pH 7.4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Tsybovsky, Y, Olia, A.S, Kwong, P.D. | | 登録日 | 2021-05-13 | | 公開日 | 2021-09-15 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | SARS-CoV-2 S2P spike ages through distinct states with altered immunogenicity.
J.Biol.Chem., 297, 2021
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7MTC
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8C78
 | | Crystal structure of human BCL6 BTB domain in complex with compound CCT374705 | | 分子名称: | (2~{S})-10-[(3-chloranyl-2-fluoranyl-pyridin-4-yl)amino]-2-cyclopropyl-3,3-bis(fluoranyl)-7-methyl-2,4-dihydro-1~{H}-[1,4]oxazepino[2,3-c]quinolin-6-one, 1,2-ETHANEDIOL, B-cell lymphoma 6 protein, ... | | 著者 | Le Bihan, Y.-V, van Montfort, R.L.M. | | 登録日 | 2023-01-13 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.
J.Med.Chem., 66, 2023
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7MTE
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7L9P
 | | Structure of human SHLD2-SHLD3-REV7-TRIP13(E253Q) complex | | 分子名称: | Mitotic spindle assembly checkpoint protein MAD2B, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Pachytene checkpoint protein 2 homolog, ... | | 著者 | Xie, W, Patel, D.J. | | 登録日 | 2021-01-04 | | 公開日 | 2021-03-03 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
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4JO2
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6A2F
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7D6B
 | | Crystal structure of Oryza sativa Os4BGlu18 monolignol beta-glucosidase with delta-gluconolactone | | 分子名称: | Beta-glucosidase 18, D-glucono-1,5-lactone, GLYCEROL, ... | | 著者 | Baiya, S, Pengthaisong, S, Ketudat Cairns, J.R. | | 登録日 | 2020-09-29 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural analysis of rice Os4BGlu18 monolignol beta-glucosidase.
Plos One, 16, 2021
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7DK3
 | | SARS-CoV-2 S trimer, S-open | | 分子名称: | Spike glycoprotein | | 著者 | Xu, C, Cong, Y. | | 登録日 | 2020-11-23 | | 公開日 | 2020-12-16 | | 最終更新日 | 2021-02-17 | | 実験手法 | ELECTRON MICROSCOPY (6 Å) | | 主引用文献 | Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.
Sci Adv, 7, 2021
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