8JT9
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![BU of 8jt9 by Molmil](/molmil-images/mine/8jt9) | Human VMAT2 complex with ketanserin | 分子名称: | 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione, Synaptic vesicular amine transporter | 著者 | Jiang, D.H, Wu, D. | 登録日 | 2023-06-21 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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7LDD
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![BU of 7ldd by Molmil](/molmil-images/mine/7ldd) | native AMPA receptor | 分子名称: | 11B8 scFv, 15F1 Fab heavy chain, 15F1 Fab light chain, ... | 著者 | Yu, J, Rao, P, Gouaux, E. | 登録日 | 2021-01-13 | 公開日 | 2021-05-12 | 最終更新日 | 2021-06-30 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. Nature, 594, 2021
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2B0R
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![BU of 2b0r by Molmil](/molmil-images/mine/2b0r) | Crystal Structure of Cyclase-Associated Protein from Cryptosporidium parvum | 分子名称: | UNKNOWN ATOM OR ION, possible adenyl cyclase-associated protein | 著者 | Tempel, W, Dong, A, Zhao, Y, Lew, J, Kozieradzki, I, Alam, Z, Melone, M, Wasney, G, Vedadi, M, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Hui, R, Bochkarev, A, Artz, J, Structural Genomics Consortium (SGC) | 登録日 | 2005-09-14 | 公開日 | 2005-09-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector J.Biol.Chem., 151, 2010
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2NPM
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![BU of 2npm by Molmil](/molmil-images/mine/2npm) | crystal structure of Cryptosporidium parvum 14-3-3 protein in complex with peptide | 分子名称: | 14-3-3 domain containing protein, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS | 著者 | Dong, A, Lew, J, Wasney, G, Ren, H, Lin, L, Hassanali, A, Qiu, W, Zhao, Y, Doyle, D, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) | 登録日 | 2006-10-27 | 公開日 | 2006-11-07 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
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3BYV
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![BU of 3byv by Molmil](/molmil-images/mine/3byv) | Crystal structure of Toxoplasma gondii specific rhoptry antigen kinase domain | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, Rhoptry kinase | 著者 | Wernimont, A.K, Lunin, V.V, Yang, C, Lew, J, Kozieradzki, I, Lin, Y.H, Sun, X, Khuu, C, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bochkarev, A, Hui, R, Sibley, D, Qiu, W, Structural Genomics Consortium (SGC) | 登録日 | 2008-01-16 | 公開日 | 2008-01-29 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii. Embo J., 28, 2009
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6CCW
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2O1O
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![BU of 2o1o by Molmil](/molmil-images/mine/2o1o) | Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with risedronate. | 分子名称: | 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, Putative farnesyl pyrophosphate synthase | 著者 | Chruszcz, M, Artz, J.D, Dong, A, Dunford, J, Lew, J, Zhao, Y, Kozieradski, I, Kavanaugh, K.L, Oppermann, U, Sundstrom, M, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Hui, R, Minor, W, Structural Genomics Consortium (SGC) | 登録日 | 2006-11-29 | 公開日 | 2006-12-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis Chem.Biol., 15, 2008
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2O8P
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![BU of 2o8p by Molmil](/molmil-images/mine/2o8p) | Crystal structure of a putative 14-3-3 protein from Cryptosporidium parvum, cgd7_2470 | 分子名称: | 14-3-3 domain containing protein | 著者 | Dong, A, Lew, J, Wasney, G, Lin, L, Hassanali, A, Zhao, Y, Vedadi, M, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Walker, J.R, Bochkarev, A, Hui, R, Brokx, S.J, Structural Genomics Consortium (SGC) | 登録日 | 2006-12-12 | 公開日 | 2007-01-09 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
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7VKA
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![BU of 7vka by Molmil](/molmil-images/mine/7vka) | Crystal Structure of GH3.6 in complex with an inhibitor | 分子名称: | ADENOSINE MONOPHOSPHATE, GLYCEROL, Indole-3-acetic acid-amido synthetase GH3.6, ... | 著者 | Wang, N, Luo, M, Bao, H, Huang, H. | 登録日 | 2021-09-29 | 公開日 | 2022-08-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation. Proc.Natl.Acad.Sci.USA, 119, 2022
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8UTA
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![BU of 8uta by Molmil](/molmil-images/mine/8uta) | yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N | 分子名称: | Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, MAGNESIUM ION, ... | 著者 | Krochmal, D, Lewicka, A, Piccirilli, J.A. | 登録日 | 2023-10-30 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structural basis for promiscuity in ligand recognition by yjdF riboswitch. Cell Discov, 10, 2024
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8UIW
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![BU of 8uiw by Molmil](/molmil-images/mine/8uiw) | yjdF riboswitch from R. gauvreauii in complex with chelerythrine bound to Fab BL3-6 S97N | 分子名称: | 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium, Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, ... | 著者 | Krochmal, D, Lewicka, A, Piccirilli, J.A. | 登録日 | 2023-10-10 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural basis for promiscuity in ligand recognition by yjdF riboswitch. Cell Discov, 10, 2024
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5CUJ
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![BU of 5cuj by Molmil](/molmil-images/mine/5cuj) | Crystal structure of Human Defensin-5 Y27A mutant crystal form 2. | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Tolbert, W.D, Gohain, N, Pazgier, M. | 登録日 | 2015-07-24 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity, 2018
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5CUM
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7EL5
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4L0W
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7WBI
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![BU of 7wbi by Molmil](/molmil-images/mine/7wbi) | BF2*1901-FLU | 分子名称: | Beta-2-microglobulin, ILE-ARG-HIS-GLU-ASN-ARG-MET-VAL-LEU, MHC class I alpha chain 2 | 著者 | Liu, W.J. | 登録日 | 2021-12-16 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease. J Immunol., 210, 2023
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7WBG
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![BU of 7wbg by Molmil](/molmil-images/mine/7wbg) | BF2*1901/RY8 | 分子名称: | ARG-ARG-ARG-GLU-GLN-THR-ASP-TYR, Beta-2-microglobulin, MHC class I alpha chain 2 | 著者 | Liu, W.J. | 登録日 | 2021-12-16 | 公開日 | 2022-12-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease. J Immunol., 210, 2023
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5CUI
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![BU of 5cui by Molmil](/molmil-images/mine/5cui) | Crystal structure of Human Defensin-5 R28A mutant. | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CHLORIDE ION, ... | 著者 | Tolbert, W.D, Gohain, N, Pazgier, M. | 登録日 | 2015-07-24 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | 主引用文献 | Human Enteric alpha-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion. Immunity, 2018
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7ELY
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7YC9
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![BU of 7yc9 by Molmil](/molmil-images/mine/7yc9) | Co-crystal structure of BTK kinase domain with inhibitor | 分子名称: | (7~{S})-2-(4-bromanyl-3,5-dimethoxy-phenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, Tyrosine-protein kinase BTK | 著者 | Zhou, X. | 登録日 | 2022-07-01 | 公開日 | 2023-05-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J.Med.Chem., 66, 2023
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7W7F
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![BU of 7w7f by Molmil](/molmil-images/mine/7w7f) | Cryo-EM structure of human NaV1.3/beta1/beta2-ICA121431 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2,2-diphenyl-~{N}-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D, Li, X. | 登録日 | 2021-12-04 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist. Nat Commun, 13, 2022
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7W77
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![BU of 7w77 by Molmil](/molmil-images/mine/7w77) | cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jiang, D, Li, X. | 登録日 | 2021-12-03 | 公開日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist. Nat Commun, 13, 2022
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8J5U
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![BU of 8j5u by Molmil](/molmil-images/mine/8j5u) | Crystal structure of Mycobacterium tuberculosis OppA complexed with an endogenous oligopeptide | 分子名称: | Endogenous oligopeptide, Uncharacterized protein Rv1280c | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 31, 2024
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8J5R
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![BU of 8j5r by Molmil](/molmil-images/mine/8j5r) | Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the resting state | 分子名称: | IRON/SULFUR CLUSTER, Putative peptide transport permease protein Rv1282c, Putative peptide transport permease protein Rv1283c, ... | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 31, 2024
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8J5S
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![BU of 8j5s by Molmil](/molmil-images/mine/8j5s) | Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the pre-catalytic intermediate state | 分子名称: | Endogenous oligopeptide, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 31, 2024
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