2LNW
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![BU of 2lnw by Molmil](/molmil-images/mine/2lnw) | Identification and structural basis for a novel interaction between Vav2 and Arap3 | 分子名称: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2 | 著者 | Wu, B, Zhang, J, Wu, J, Shi, Y. | 登録日 | 2012-01-05 | 公開日 | 2012-11-21 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
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5EYC
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![BU of 5eyc by Molmil](/molmil-images/mine/5eyc) | Crystal structure of c-Met in complex with naphthyridinone inhibitor 5 | 分子名称: | 6-[(1~{R})-1-[8-fluoranyl-6-(3-methyl-1,2-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-1,6-naphthyridin-5-one, Hepatocyte growth factor receptor | 著者 | Whittington, D.A, Long, A.M. | 登録日 | 2015-11-24 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity. J.Med.Chem., 59, 2016
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5EYD
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![BU of 5eyd by Molmil](/molmil-images/mine/5eyd) | Crystal structure of c-Met in complex with AMG 337 | 分子名称: | 6-[(1~{R})-1-[8-fluoranyl-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one, Hepatocyte growth factor receptor | 著者 | Whittington, D.A, Long, A.M. | 登録日 | 2015-11-24 | 公開日 | 2016-02-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity. J.Med.Chem., 59, 2016
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7X08
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![BU of 7x08 by Molmil](/molmil-images/mine/7x08) | S protein of SARS-CoV-2 in complex with 2G1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | 著者 | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | 登録日 | 2022-02-21 | 公開日 | 2022-03-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD. Cell Discov, 8, 2022
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8IYX
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![BU of 8iyx by Molmil](/molmil-images/mine/8iyx) | Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365 | 分子名称: | 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365 | 著者 | Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M. | 登録日 | 2023-04-06 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
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2HC5
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![BU of 2hc5 by Molmil](/molmil-images/mine/2hc5) | Solution NMR Structure of Protein yvyC from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR482. | 分子名称: | Hypothetical protein yvyC | 著者 | Eletsky, A, Liu, G, Atreya, H.S, Sukumaran, D.K, Wang, D, Cunningham, K, Janjua, H, Ma, L.-C, Xiao, R, Liu, J, Baran, M, Acton, T.B, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-06-15 | 公開日 | 2006-08-15 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of protein YvyC from Bacillus subtilis reveals unexpected structural similarity between two PFAM families. Proteins, 76, 2009
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7Y3G
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![BU of 7y3g by Molmil](/molmil-images/mine/7y3g) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | G-protein coupled receptor 12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Li, H, Zhang, J.Y, Luo, F. | 登録日 | 2022-06-10 | 公開日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structural insight into the constitutive activity of human orphan receptor GPR12. Sci Bull (Beijing), 68, 2023
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8XB4
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![BU of 8xb4 by Molmil](/molmil-images/mine/8xb4) | |
8XB3
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8OVZ
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![BU of 8ovz by Molmil](/molmil-images/mine/8ovz) | Crystal structure of D1228V c-MET bound by compound 16 | 分子名称: | 1-[(1S)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl]-5-(1H-indazol-7-yl)pyrimidine-2,4-dione, Hepatocyte growth factor receptor, IODIDE ION | 著者 | Collie, G.W. | 登録日 | 2023-04-26 | 公開日 | 2023-07-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
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8OUU
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![BU of 8ouu by Molmil](/molmil-images/mine/8ouu) | Crystal structure of D1228V c-MET bound by compound 29 | 分子名称: | 1,2-ETHANEDIOL, 5-(3-ethynyl-5-fluoranyl-1H-indazol-7-yl)-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, FORMIC ACID, ... | 著者 | Collie, G.W. | 登録日 | 2023-04-24 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
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8OUV
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![BU of 8ouv by Molmil](/molmil-images/mine/8ouv) | Crystal structure of D1228V c-MET bound by compound 15 | 分子名称: | 5-(1H-indazol-7-yl)-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, CHLORIDE ION, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2023-04-24 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.783 Å) | 主引用文献 | Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
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8OW3
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![BU of 8ow3 by Molmil](/molmil-images/mine/8ow3) | Crystal structure of wild-type c-MET bound by compound 2 | 分子名称: | 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2023-04-26 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
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8OV7
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![BU of 8ov7 by Molmil](/molmil-images/mine/8ov7) | Crystal structure of D1228V c-MET bound by compound 10 | 分子名称: | 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-[3-(1H-imidazol-5-yl)phenyl]ethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2023-04-25 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
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8XB2
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![BU of 8xb2 by Molmil](/molmil-images/mine/8xb2) | Structure of radafaxine-bound state of the human Norepinephrine Transporter | 分子名称: | (2~{S},3~{S})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholin-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter | 著者 | Wu, J.X, Ji, W.M. | 登録日 | 2023-12-05 | 公開日 | 2024-07-10 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Substrate binding and inhibition mechanism of norepinephrine transporter. Nature, 2024
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8OWG
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![BU of 8owg by Molmil](/molmil-images/mine/8owg) | Crystal structure of D1228V c-MET bound by compound 2 | 分子名称: | 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2023-04-27 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.631 Å) | 主引用文献 | Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66, 2023
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2JN0
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![BU of 2jn0 by Molmil](/molmil-images/mine/2jn0) | Solution NMR structure of the ygdR protein from Escherichia coli. Northeast Structural Genomics target ER382A. | 分子名称: | Hypothetical lipoprotein ygdR | 著者 | Rossi, P, Chen, C.X, Jiang, M, Cunningham, K, Ma, L, Xiao, R, Liu, J.C, Baran, M, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-12-15 | 公開日 | 2007-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR structure of the ygdR protein from Escherichia coli. Northeast Structural Genomics target ER382A. To be Published
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5WQ4
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7Y90
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![BU of 7y90 by Molmil](/molmil-images/mine/7y90) | Crystal Structure Analysis of cp1 bound BCL2 | 分子名称: | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide | 著者 | Li, F.W. | 登録日 | 2022-06-24 | 公開日 | 2023-11-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy. Nat Commun, 15, 2024
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2KCV
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![BU of 2kcv by Molmil](/molmil-images/mine/2kcv) | Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c | 分子名称: | Tetratricopeptide repeat domain protein | 著者 | Liu, G, Rossi, P, Wang, D, Nwosu, C, Owens, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-12-29 | 公開日 | 2009-01-20 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution nmr structure of tetratricopeptide repeat domain protein sru_0103 from salinibacter ruber, northeast structural genomics consortium (nesg) target srr115c To be Published
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3GZ9
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![BU of 3gz9 by Molmil](/molmil-images/mine/3gz9) | Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd) in Complex with a Full Agonist | 分子名称: | (2,3-dimethyl-4-{[2-(prop-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}phenoxy)acetic acid, Peroxisome proliferator-activated receptor delta, heptyl beta-D-glucopyranoside | 著者 | Wang, Z, Sudom, A, Walker, N.P. | 登録日 | 2009-04-06 | 公開日 | 2009-06-30 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma. Bioorg.Med.Chem.Lett., 19, 2009
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3FYE
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![BU of 3fye by Molmil](/molmil-images/mine/3fye) | Catalytic core subunits (I and II) of cytochrome c oxidase from Rhodobacter sphaeroides in the reduced state | 分子名称: | CADMIUM ION, CALCIUM ION, COPPER (I) ION, ... | 著者 | Qin, L, Mills, D.A, Proshlyakov, D.A, Hiser, C, Ferguson-Miller, S. | 登録日 | 2009-01-22 | 公開日 | 2009-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Redox dependent conformational changes in cytochrome c oxidase suggest a gating mechanism for proton uptake. Biochemistry, 48, 2009
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6MTY
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![BU of 6mty by Molmil](/molmil-images/mine/6mty) | Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 isolated following ZPIV vaccination | 分子名称: | MZ4 Heavy Chain, MZ4 Light Chain | 著者 | Sankhala, R.S, Dussupt, V, Donofrio, G, Choe, M, Modjarrad, K, Michael, N.L, Krebs, S.J, Joyce, M.G. | 登録日 | 2018-10-22 | 公開日 | 2019-12-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.951 Å) | 主引用文献 | Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. Nat Med, 26, 2020
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3FYI
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![BU of 3fyi by Molmil](/molmil-images/mine/3fyi) | Catalytic core subunits (I and II) of cytochrome C oxidase from Rhodobacter sphaeroides in the reduced state bound with cyanide | 分子名称: | CADMIUM ION, CALCIUM ION, COPPER (I) ION, ... | 著者 | Qin, L, Mills, D.A, Proshlyakov, D.A, Hiser, C, Ferguson-Miller, S. | 登録日 | 2009-01-22 | 公開日 | 2009-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Redox dependent conformational changes in cytochrome c oxidase suggest a gating mechanism for proton uptake. Biochemistry, 48, 2009
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3HQM
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