8OV7

Crystal structure of D1228V c-MET bound by compound 10

Summary for 8OV7

Entry DOI	10.2210/pdb8ov7/pdb
Descriptor	Hepatocyte growth factor receptor, 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-[3-(1H-imidazol-5-yl)phenyl]ethyl]pyrimidine-2,4-dione (3 entities in total)
Functional Keywords	kinase, inhibitor, cancer research, drug discovery, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35220.74
Authors	Collie, G.W. (deposition date: 2023-04-25, release date: 2023-07-05, Last modification date: 2023-07-26)
Primary citation	Michaelides, I.N.,Collie, G.W.,Borjesson, U.,Vasalou, C.,Alkhatib, O.,Barlind, L.,Cheung, T.,Dale, I.L.,Embrey, K.J.,Hennessy, E.J.,Khurana, P.,Koh, C.M.,Lamb, M.L.,Liu, J.,Moss, T.A.,O'Neill, D.J.,Phillips, C.,Shaw, J.,Snijder, A.,Storer, R.I.,Stubbs, C.J.,Han, F.,Li, C.,Qiao, J.,Sun, D.Q.,Wang, J.,Wang, P.,Yang, W. Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J.Med.Chem., 66:8782-8807, 2023 Cited by PubMed: 37343272 DOI: 10.1021/acs.jmedchem.3c00401 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation