8OV7

Crystal structure of D1228V c-MET bound by compound 10

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	DIAMOND BEAMLINE I03
Synchrotron site	Diamond
Beamline	I03
Temperature [K]	100
Detector technology	PIXEL
Collection date	2017-07-07
Detector	DECTRIS PILATUS 6M
Wavelength(s)	0.97625
Spacegroup name	P 41 21 2
Unit cell lengths	111.645, 111.645, 130.432
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	28.270 - 1.950
R-factor	0.2737
Rwork	0.273
R-free	0.28700
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.008
RMSD bond angle	0.900
Data reduction software	DIALS
Data scaling software	DIALS
Phasing software	PHASER
Refinement software	BUSTER (2.11.8 (8-JUN-2022))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	78.940	1.980
High resolution limit [Å]	1.950	1.950
Number of reflections	60639	2948
<I/σ(I)>	9.6
Completeness [%]	100.0
Redundancy	12.5
CC(1/2)	0.998	0.512

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION		293	1.5 M LiCl, 0.1 M Na HEPES pH 7.5