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AtOSCA1.1 extended state
分子名称:	Protein OSCA1, [1-MYRISTOYL-GLYCEROL-3-YL]PHOSPHONYLCHOLINE
著者	Zhang, M.F.
登録日	2022-09-02
公開日	2023-06-14
最終更新日	2023-07-26
実験手法	ELECTRON MICROSCOPY (2.5 Å)
主引用文献	A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity. Nat Commun, 14, 2023

8GSO

AtOSCA3.1 channel extended state
分子名称:	CSC1-like protein ERD4
著者	Zhang, M.F.
登録日	2022-09-06
公開日	2023-06-14
最終更新日	2023-07-26
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity. Nat Commun, 14, 2023

8GRO

AtOSCA3.1 contracted state
分子名称:	CSC1-like protein ERD4
著者	Zhang, M.F.
登録日	2022-09-02
公開日	2023-06-14
最終更新日	2023-07-26
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity. Nat Commun, 14, 2023

5L0A

Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with fructose-1,6-bisphosphate
分子名称:	1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2
著者	Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
登録日	2016-07-27
公開日	2017-08-16
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.302 Å)
主引用文献	Structural studies of human muscle FBPase To Be Published

7YR5

Embigin facilitates monocarboxylate transporter 1 localization to plasma membrane and transition to a decoupling state
分子名称:	Embigin, Monocarboxylate transporter 1
著者	Xu, B, Ye, S.
登録日	2022-08-08
公開日	2022-09-28
実験手法	ELECTRON MICROSCOPY (3.63 Å)
主引用文献	Embigin facilitates monocarboxylate transporter 1 localization to the plasma membrane and transition to a decoupling state. Cell Rep, 40, 2022

5K56

Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-1,6-bisphosphate
分子名称:	1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2
著者	Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
登録日	2016-05-23
公開日	2017-06-07
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.198 Å)
主引用文献	Structural studies of human muscle FBPase To Be Published

6JXT

Crystal structure of EGFR 696-1022 WT in complex with AZD9291 prepared by cocrystallization
分子名称:	CHLORIDE ION, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者	Yun, C.H, Zhu, S.J, Yan, X.E.
登録日	2019-04-25
公開日	2020-04-29
最終更新日	2020-11-04
実験手法	X-RAY DIFFRACTION (2.307 Å)
主引用文献	Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63, 2020

6JX0

Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by co-crystallization
分子名称:	CHLORIDE ION, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者	Yun, C.H, Yan, X.E, Zhu, S.J.
登録日	2019-04-21
公開日	2020-04-22
最終更新日	2020-11-04
実験手法	X-RAY DIFFRACTION (2.53 Å)
主引用文献	Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63, 2020

6JWL

Crystal structure of EGFR 696-1022 L858R in complex with AZD9291
分子名称:	Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者	Yun, C.H, Zhu, S.J, Yan, X.E.
登録日	2019-04-21
公開日	2020-04-22
最終更新日	2020-11-04
実験手法	X-RAY DIFFRACTION (2.551 Å)
主引用文献	Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63, 2020

6JX4

Crystal structure of EGFR 696-1022 T790M in complex with AZD9291 prepared by soaking
分子名称:	Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
著者	Zhu, S.J, Yan, X.E, Yun, C.H.
登録日	2019-04-22
公開日	2020-04-22
最終更新日	2020-11-04
実験手法	X-RAY DIFFRACTION (2.531 Å)
主引用文献	Structural Basis of AZD9291 Selectivity for EGFR T790M. J.Med.Chem., 63, 2020

6LTN

cryo-EM structure of C-terminal truncated human Pannexin1
分子名称:	Pannexin-1
著者	Mou, L.Q, Ke, M, Xiao, Q.J, Wu, J.P, Deng, D.
登録日	2020-01-23
公開日	2020-05-13
最終更新日	2020-05-27
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural basis for gating mechanism of Pannexin 1 channel. Cell Res., 30, 2020

6LTO

cryo-EM structure of full length human Pannexin1
分子名称:	Pannexin-1
著者	Mou, L.Q, Ke, M, Xiao, Q.J, Wu, J.P, Deng, D.
登録日	2020-01-23
公開日	2020-05-13
最終更新日	2020-05-27
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural basis for gating mechanism of Pannexin 1 channel. Cell Res., 30, 2020

7YIJ

Human KCNH5 pore dilation but the non-conducting state
分子名称:	POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5
著者	Zhang, M.F.
登録日	2022-07-16
公開日	2023-04-05
実験手法	ELECTRON MICROSCOPY (3.8 Å)
主引用文献	Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel. Nat Commun, 14, 2023

5ET5

Human muscle fructose-1,6-bisphosphatase in active R-state
分子名称:	Fructose-1,6-bisphosphatase isozyme 2
著者	Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
登録日	2015-11-17
公開日	2016-04-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.67 Å)
主引用文献	T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016

5ET8

Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate
分子名称:	6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2
著者	Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
登録日	2015-11-17
公開日	2016-11-23
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.92 Å)
主引用文献	T-to-R switch of muscle FBPase involves extreme changes of secondary and quaternary structure To Be Published

5ET6

Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP
分子名称:	ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase isozyme 2
著者	Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
登録日	2015-11-17
公開日	2016-04-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (1.845 Å)
主引用文献	T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016

5ET7

Human muscle fructose-1,6-bisphosphatase in inactive T-state
分子名称:	Fructose-1,6-bisphosphatase isozyme 2
著者	Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D.
登録日	2015-11-17
公開日	2016-04-13
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.989 Å)
主引用文献	T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016

6TWR

Structure of a constitutively active CAT-PRD1 mutant of the antiterminator LicT protein.
分子名称:	Beta-glucoside bgl operon antiterminator BglG family
著者	Demene, H, Declerck, N, Yinshan, Y.
登録日	2020-01-13
公開日	2021-04-14
最終更新日	2024-06-19
実験手法	SOLUTION NMR
主引用文献	Resolving the activation mechanism of the D99N antiterminator LicT protein. J.Struct.Biol., 213, 2021

8T51

Crystal structure of Fab 3.10C2 bound to TREM2
分子名称:	3.10C2 Fab heavy chain, 3.10C2 Fab light chain, ACETATE ION, ...
著者	Hsu, P.L, Wallweber, H.
登録日	2023-06-12
公開日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining To Be Published

5DLP

Acetylcholinesterase Methylene Blue no PEG
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, Acetylcholinesterase, ...
著者	Dym, O.
登録日	2015-09-07
公開日	2016-03-30
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex. Protein Sci., 25, 2016

5E4J

Acetylcholinesterase Methylene Blue no PEG
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, DECAMETHONIUM ION, ...
著者	Dym, O.
登録日	2015-10-06
公開日	2016-03-30
最終更新日	2021-05-12
実験手法	X-RAY DIFFRACTION (2.54 Å)
主引用文献	The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex. Protein Sci., 25, 2016

5E4T

Acetylcholinesterase Methylene Blue with PEG
分子名称:	1,2-ETHANEDIOL, 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM, Acetylcholinesterase, ...
著者	Dym, O.
登録日	2015-10-07
公開日	2016-03-30
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.43 Å)
主引用文献	The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex. Protein Sci., 25, 2016

5E2I

Acetylcholinesterase Methylene Blue no PEG
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, DECAMETHONIUM ION, ...
著者	Dym, O.
登録日	2015-10-01
公開日	2016-03-30
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex. Protein Sci., 25, 2016

5C5S

Crystal Structure of human Myosin 9b RhoGAP domain at 2.2 angstrom
分子名称:	Unconventional myosin-IXb
著者	Yi, F.S, Ren, J.Q, Feng, W.
登録日	2015-06-22
公開日	2015-11-25
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression J.Clin.Invest., 125, 2015

4LEX

Unliganded crystal structure of mAb7
分子名称:	FAB HEAVY CHAIN, FAB LIGHT CHAIN
著者	Murray, J.M, Mukund, S.
登録日	2013-06-26
公開日	2013-11-13
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.02 Å)
主引用文献	Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor. J.Biol.Chem., 288, 2013

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