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1H8F
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BU of 1h8f by Molmil
Glycogen Synthase Kinase 3 beta.
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCOGEN SYNTHASE KINASE-3 BETA
著者Dajani, R, Pearl, L.H, Roe, S.M.
登録日2001-02-05
公開日2002-01-31
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Glycogen Synthase Kinase 3Beta . Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition
Cell(Cambridge,Mass.), 105, 2001
1GS0
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BU of 1gs0 by Molmil
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2
分子名称: POLY (ADP-RIBOSE) POLYMERASE-2
著者Oliver, A.W, Roe, S.M, Pearl, L.H.
登録日2001-12-19
公開日2002-12-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Catalytic Fragment of Murine Poly(Adp-Ribose) Polymerase-2
Nucleic Acids Res., 32, 2004
1GML
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BU of 1gml by Molmil
crystal structure of the mouse CCT gamma apical domain (triclinic)
分子名称: GLYCEROL, T-COMPLEX PROTEIN 1 SUBUNIT GAMMA
著者Pappenberger, G, Wilsher, J.A, Roe, S.M, Willison, K.R, Pearl, L.H.
登録日2001-09-17
公開日2002-06-18
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin
J.Mol.Biol., 318, 2002
1GN1
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BU of 1gn1 by Molmil
crystal structure of the mouse CCT gamma apical domain (monoclinic)
分子名称: CALCIUM ION, CCT-GAMMA
著者Pappenberger, G, Wilsher, J.A, Roe, S.M, Willison, K.R, Pearl, L.H.
登録日2001-10-01
公開日2002-06-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin
J.Mol.Biol., 318, 2002
1GEC
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BU of 1gec by Molmil
GLYCYL ENDOPEPTIDASE-COMPLEX WITH BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE COVALENTLY BOUND TO CYSTEINE 25
分子名称: BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE INHIBITOR, GLYCYL ENDOPEPTIDASE
著者Ohara, B.P, Hemmings, A.M, Buttle, D.J, Pearl, L.H.
登録日1995-05-25
公開日1995-12-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of glycyl endopeptidase from Carica papaya: a cysteine endopeptidase of unusual substrate specificity.
Biochemistry, 34, 1995
1HK7
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BU of 1hk7 by Molmil
Middle Domain of HSP90
分子名称: CADMIUM ION, HEAT SHOCK PROTEIN HSP82, MAGNESIUM ION
著者Meyer, P, Prodromou, C, Roe, S.M, Pearl, L.H.
登録日2003-03-06
公開日2004-01-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Mol.Cell, 11, 2003
2V74
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Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with S-adenosyl-homocysteine
分子名称: HISTONE-ARGININE METHYLTRANSFERASE CARM1, S-ADENOSYL-L-HOMOCYSTEINE
著者Yue, W.W, Hassler, M, Roe, S.M, Thompson-Vale, V, Pearl, L.H.
登録日2007-07-26
公開日2007-10-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insights Into Histone Code Syntax from Structural and Biochemical Studies of Carm1 Methyltransferase
Embo J., 26, 2007
2V7E
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BU of 2v7e by Molmil
Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), unliganded
分子名称: HISTONE-ARGININE METHYLTRANSFERASE CARM1, MERCURY (II) ION
著者Yue, W.W, Hassler, M, Roe, S.M, Thompson-Vale, V, Pearl, L.H.
登録日2007-07-30
公開日2007-10-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insights Into Histone Code Syntax from Structural and Biochemical Studies of Carm1 Methyltransferase
Embo J., 26, 2007
2VXC
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BU of 2vxc by Molmil
Structure of the Crb2-BRCT2 domain complex with phosphopeptide.
分子名称: DNA REPAIR PROTEIN RHP9, H2A1 PEPTIDE, PRASEODYMIUM ION
著者Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2008-07-03
公開日2008-08-12
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural and Functional Analysis of the Crb2-Brct2 Domain Reveals Distinct Roles in Checkpoint Signaling and DNA Damage Repair.
Genes Dev., 22, 2008
2W2T
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BU of 2w2t by Molmil
Rac2 (G12V) in complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2W2V
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Rac2 (G12V) in complex with GTPgS
分子名称: GUANOSINE-5'-TRIPHOSPHATE, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2WEQ
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BU of 2weq by Molmil
Yeast Hsp90 N-terminal domain LI-IV mutant with Geldanamycin
分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN, GLYCEROL
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2009-04-01
公開日2009-04-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90
Acs Chem.Biol., 4, 2009
2WEP
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BU of 2wep by Molmil
Yeast Hsp90 N-terminal domain LI-IV mutant with ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2009-04-01
公開日2009-04-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90.
Acs Chem.Biol., 4, 2009
2W18
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Crystal structure of the C-terminal WD40 domain of human PALB2
分子名称: GLYCEROL, PARTNER AND LOCALIZER OF BRCA2
著者Oliver, A.W, Pearl, L.H.
登録日2008-10-15
公開日2009-07-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Recruitment of Brca2 by Palb2
Embo Rep., 10, 2009
2WTJ
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
分子名称: 1,2-ETHANEDIOL, 2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE, CHECKPOINT KINASE 2, ...
著者Hilton, S, Naud, S, Caldwell, J.J, Boxall, K, Burns, S, Anderson, V.E, Antoni, L, Allen, C.E, Pearl, L.H, Oliver, A.W, Aherne, G.W, Garrett, M.D, Collins, I.
登録日2009-09-16
公開日2009-12-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2VXB
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Structure of the Crb2-BRCT2 domain
分子名称: DNA REPAIR PROTEIN RHP9, PRASEODYMIUM ION
著者Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2008-07-03
公開日2008-08-12
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Functional Analysis of the Crb2-Brct2 Domain Reveals Distinct Roles in Checkpoint Signaling and DNA Damage Repair.
Genes Dev., 22, 2008
2XNH
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BU of 2xnh by Molmil
Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1
分子名称: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, IODIDE ION
著者Rappas, M, Oliver, A.W, Pearl, L.H.
登録日2010-08-02
公開日2010-09-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
2WER
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Yeast Hsp90 N-terminal domain LI-IV mutant with Radicicol
分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, RADICICOL
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2009-04-01
公開日2009-04-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90.
Acs Chem.Biol., 4, 2009
2W2W
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BU of 2w2w by Molmil
PLCg2 Split Pleckstrin Homology (PH) Domain
分子名称: 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2W3O
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Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide
分子名称: BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, CALCIUM ION, DNA REPAIR PROTEIN XRCC1
著者Oliver, A.W, Ali, A.A.E, Pearl, L.H.
登録日2008-11-13
公開日2009-02-03
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Nucleic Acids Res., 37, 2009
2XNK
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Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1
分子名称: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, GLYCEROL
著者Rappas, M, Oliver, A.W, Pearl, L.H.
登録日2010-08-03
公開日2010-09-01
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
2WTD
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Crystal structure of Chk2 in complex with an inhibitor
分子名称: 1,2-ETHANEDIOL, 4-[2-AMINO-5-(1,3-BENZODIOXOL-4-YL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, ...
著者Hilton, S, Naud, S, Caldwell, J.J, Boxall, K, Burns, S, Anderson, V.E, Antoni, L, Allen, C.E, Pearl, L.H, Oliver, A.W, Aherne, G.W, Garrett, M.D, Collins, I.
登録日2009-09-15
公開日2009-12-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2WTC
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CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR
分子名称: 4-[2-AMINO-5-(4-HYDROXY-3-METHOXYPHENYL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
著者Hilton, S, Naud, S, Caldwell, J.J, Boxall, K, Burns, S, Anderson, V.E, Antoni, L, Allen, C.E, Pearl, L.H, Oliver, A.W, Aherne, G.W, Garrett, M.D, Collins, I.
登録日2009-09-15
公開日2009-12-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2
Bioorg.Med.Chem., 18, 2010
2W2X
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Complex of Rac2 and PLCg2 spPH Domain
分子名称: 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ...
著者Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H.
登録日2008-11-04
公開日2009-05-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2.
Mol.Cell, 34, 2009
2VWC
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STRUCTURE OF THE HSP90 INHIBITOR MACBECIN BOUND TO THE N-TERMINUS OF YEAST HSP90.
分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GLYCEROL, MACBECIN
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2008-06-20
公開日2008-07-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular Characterisation of Macbecin as an Hsp90 Inhibitor
J.Med.Chem., 51, 2008

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