8WCF
 
 | | Crystal structure of EcThsB | | 分子名称: | Molecular chaperone Tir, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2023-09-12 | | 公開日 | 2024-09-18 | | 最終更新日 | 2025-07-02 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Self-association activates ThsB NAD + hydrolase for defense against phage infection.
Biochem.Biophys.Res.Commun., 776, 2025
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8WC0
 | | Crystal structure of EcThsA | | 分子名称: | GLYCEROL, NAD(+) hydrolase ThsA, SODIUM ION, ... | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2023-09-11 | | 公開日 | 2024-09-18 | | 最終更新日 | 2025-07-02 | | 実験手法 | X-RAY DIFFRACTION (2.249 Å) | | 主引用文献 | Self-association activates ThsB NAD + hydrolase for defense against phage infection.
Biochem.Biophys.Res.Commun., 776, 2025
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8J4U
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6LP7
 | | Crystal structure of human DHODH in complex with inhibitor 0944 | | 分子名称: | 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2020-01-09 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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6LP6
 | | Crystal structure of human DHODH in complex with inhibitor 1214 | | 分子名称: | 3-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2020-01-09 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | | 主引用文献 | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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6LP8
 | | Crystal structure of human DHODH in complex with inhibitor 1243 | | 分子名称: | 3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2020-01-09 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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6KNZ
 | | Crystal structure of T2R-TTL-KXO1 complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-~{N}-(phenylmethyl)ethanamide, CALCIUM ION, ... | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2019-08-07 | | 公開日 | 2019-10-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.475 Å) | | 主引用文献 | Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity.
J.Biol.Chem., 294, 2019
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8ZGI
 | | Crystal structure of DUF4297 from E.Coli | | 分子名称: | Restriction endonuclease | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2024-05-09 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | DUF4297 and HerA form abortosome to mediate bacterial immunity against phage infection.
Mol.Cell, 85, 2025
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8JKH
 | | CryoEM structure of sNS1 complexed with Fab 4B8 | | 分子名称: | NS1, the heavy chain of antibody 4B8, the light chain of antibody 4B8 | | 著者 | Chen, Q, Pan, Q. | | 登録日 | 2023-06-01 | | 公開日 | 2024-12-04 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8JQS
 | | CryoEM structure of sNS1 complexed with Fab 14G5 | | 分子名称: | 14G5 Fab Heavy Chain, 14G5 Fab Light Chain, Non-structural protein 1 | | 著者 | Chen, Q, Pan, Q. | | 登録日 | 2023-06-14 | | 公開日 | 2024-12-04 | | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | | 主引用文献 | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8JQN
 | | CryoEM structure of sNS1 complexed with Fab 2E11 | | 分子名称: | 2E11 Fab Heavy Chain, 2E11 Fab Light Chain, Non-structural protein 1 | | 著者 | Chen, Q, Qi, P. | | 登録日 | 2023-06-14 | | 公開日 | 2024-12-11 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8JKF
 | | CryoEM structure of sNS1 complexed with Fab 3G2 | | 分子名称: | NS1, the heavy chain of antibody 3G2, the light chain of antibody 3G2 | | 著者 | Chen, Q, Qi, P. | | 登録日 | 2023-06-01 | | 公開日 | 2024-12-11 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8JQM
 | | CryoEM structure of sNS1 complexed with Fab 4F10 | | 分子名称: | 4F10 Fab Heavy Chain, 4F10 Fab Light Chain, Non-structural protein 1 | | 著者 | Chen, Q, Qi, P. | | 登録日 | 2023-06-14 | | 公開日 | 2024-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
Hlife, 2, 2024
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8X4C
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8X4B
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8X4A
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8X49
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8X4D
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8X48
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8X4E
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3Q5Y
 | | V beta/V beta homodimerization-based pre-TCR model suggested by TCR beta crystal structures | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Chen, Q, Zhang, H, Wang, J.-H. | | 登録日 | 2010-12-30 | | 公開日 | 2011-03-09 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A conserved hydrophobic patch on Vbeta domains revealed by TCRbeta chain crystal structures: implications for pre-TCR dimerization
Front Immunol, 2, 2011
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3Q5T
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3EAO
 | | Crystal structure of recombinant rat selenoprotein thioredoxin reductase 1 with oxidized C-terminal tail | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin reductase 1, ... | | 著者 | Sandalova, T, Cheng, Q, Lindqvist, Y, Arner, E. | | 登録日 | 2008-08-26 | | 公開日 | 2008-12-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1.
J.Biol.Chem., 284, 2009
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3EAN
 | | Crystal structure of recombinant rat selenoprotein thioredoxin reductase 1 with reduced C-terminal tail | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Thioredoxin reductase 1 | | 著者 | Sandalova, T, Cheng, Q, Lindqvist, Y, Arner, E. | | 登録日 | 2008-08-26 | | 公開日 | 2008-12-02 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1.
J.Biol.Chem., 284, 2009
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7RPM
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