6ZE1
| human NBD1 of CFTR in complex with nanobody G11a | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, ... | 著者 | Garcia-Pino, A, Govaerts, C, Scholl, D, Sigoillot, M. | 登録日 | 2020-06-15 | 公開日 | 2021-06-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.705 Å) | 主引用文献 | A topological switch in CFTR modulates channel activity and sensitivity to unfolding. Nat.Chem.Biol., 17, 2021
|
|
6XS6
| SARS-CoV-2 Spike D614G variant, minus RBD | 分子名称: | Spike glycoprotein | 著者 | Wang, X, Egri, S.B, Dudkina, N, Luban, J, Shen, K. | 登録日 | 2020-07-15 | 公開日 | 2020-07-22 | 最終更新日 | 2020-11-11 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell, 183, 2020
|
|
3N9N
| ceKDM7A from C.elegans, complex with H3K4me3K9me2 peptide and NOG | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | 登録日 | 2010-05-31 | 公開日 | 2010-06-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res., 20, 2010
|
|
3N9L
| ceKDM7A from C.elegans, complex with H3K4me3 peptide and NOG | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | 登録日 | 2010-05-31 | 公開日 | 2010-06-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res., 20, 2010
|
|
3N9P
| ceKDM7A from C.elegans, complex with H3K4me3K27me2 peptide and NOG | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | 登録日 | 2010-05-31 | 公開日 | 2010-06-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.388 Å) | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res., 20, 2010
|
|
3N9O
| ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K9me2 peptide and NOG | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | 登録日 | 2010-05-31 | 公開日 | 2010-06-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.309 Å) | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res., 20, 2010
|
|
3N9M
| ceKDM7A from C.elegans, alone | 分子名称: | FE (II) ION, Putative uncharacterized protein, ZINC ION | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | 登録日 | 2010-05-31 | 公開日 | 2010-06-30 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.493 Å) | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res., 20, 2010
|
|
3N9Q
| ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K27me2 peptide and NOG | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | 登録日 | 2010-05-31 | 公開日 | 2010-06-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans Cell Res., 20, 2010
|
|
8H59
| A fungal MAP kinase in complex with an inhibitor | 分子名称: | Mitogen-activated protein kinase MPS1, ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide | 著者 | Kong, Z, Zhang, X, Wang, D, Liu, J. | 登録日 | 2022-10-12 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi. Mbio, 14, 2023
|
|
6NF2
| |
6OSY
| |
6OT1
| |
6PM9
| Crystal structure of the core catalytic domain of human O-GlcNAcase bound to MK-8719 | 分子名称: | (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol, O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain | 著者 | Klein, D.J, Selnick, H.G, Duffy, J.L, McEachern, E.J. | 登録日 | 2019-07-01 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J.Med.Chem., 62, 2019
|
|
7V9M
| Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Chen, X, Yang, D.H, Wang, M.W. | 登録日 | 2021-08-26 | 公開日 | 2021-10-20 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
5I86
| Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02778174 | 分子名称: | (4R)-N-benzyl-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-6-carboxamide, 1,2-ETHANEDIOL, CREB-binding protein, ... | 著者 | Jayaram, H, Poy, F, Setser, J.W, Bellon, S.F. | 登録日 | 2016-02-18 | 公開日 | 2016-04-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett., 7, 2016
|
|
7KLZ
| |
6WXL
| |
3JCO
| Structure of yeast 26S proteasome in M1 state derived from Titan dataset | 分子名称: | 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... | 著者 | Luan, B, Huang, X.L, Wu, J.P, Shi, Y.G, Wang, F. | 登録日 | 2016-01-06 | 公開日 | 2016-06-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structure of an endogenous yeast 26S proteasome reveals two major conformational states. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
1QT1
| |
5I8G
| CBP in complex with Cpd637 ((R)-4-methyl-6-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-1,3,4,5-tetrahydro-2H-benzo[b][1,4]diazepin-2-one) | 分子名称: | (4R)-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Murray, J.M. | 登録日 | 2016-02-18 | 公開日 | 2016-04-20 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). Acs Med.Chem.Lett., 7, 2016
|
|
5KIT
| |
6C0S
| |
6NIH
| Crystal structure of human TLR1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Su, L, Zhang, H. | 登録日 | 2018-12-27 | 公開日 | 2019-04-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim. J. Med. Chem., 62, 2019
|
|
8HE4
| The structure of chitin deacetylase Pst_13661 from Puccinia striiformis f. sp. tritici | 分子名称: | Chitin deacetylase, ZINC ION, ~{N}-oxidanylnaphthalene-1-carboxamide | 著者 | Liu, L, Li, Y.C, Zhou, Y, Yang, Q. | 登録日 | 2022-11-07 | 公開日 | 2023-05-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Inhibition of chitin deacetylases to attenuate plant fungal diseases. Nat Commun, 14, 2023
|
|
8HE2
| The structure of chitin deacetylase Pst_13661 from Puccinia striiformis f. sp. tritici | 分子名称: | Chitin deacetylase, ZINC ION, tert-butyl N-[3-[[4-(oxidanylcarbamoyl)phenyl]methylamino]-3-oxidanylidene-propyl]carbamate | 著者 | Liu, L, Li, Y.C, Zhou, Y, Yang, Q. | 登録日 | 2022-11-07 | 公開日 | 2023-05-31 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Inhibition of chitin deacetylases to attenuate plant fungal diseases. Nat Commun, 14, 2023
|
|