8QYR
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![BU of 8qyr by Molmil](/molmil-images/mine/8qyr) | Beta-cardiac myosin motor domain in the pre-powerstroke state complexed to Mavacamten | 分子名称: | 1,2-ETHANEDIOL, 6-[[(1~{S})-1-phenylethyl]amino]-3-propan-2-yl-1~{H}-pyrimidine-2,4-dione, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A. | 登録日 | 2023-10-26 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction. Biorxiv, 2023
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6ZQU
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![BU of 6zqu by Molmil](/molmil-images/mine/6zqu) | Cryo-EM structure of mature Dengue virus 2 at 3.1 angstrom resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein | 著者 | Renner, M, Dejnirattisai, W, Carrique, L, Serna Martin, I, Karia, D, Ilca, S.L, Ho, S.F, Kotecha, A, Keown, J.R, Mongkolsapaya, J, Screaton, G.R, Grimes, J.M. | 登録日 | 2020-07-10 | 公開日 | 2021-01-20 | 最終更新日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins. Nat Commun, 12, 2021
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8QB3
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![BU of 8qb3 by Molmil](/molmil-images/mine/8qb3) | ADDobody zinc containing condition | 分子名称: | ADDobody, ZINC ION | 著者 | Buzas, D, Toelzer, C, Berger, I, Schaffitzel, C. | 登録日 | 2023-08-24 | 公開日 | 2023-12-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders. Structure, 32, 2024
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7BON
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![BU of 7bon by Molmil](/molmil-images/mine/7bon) | Crystal structure of recombinant horse spleen apo-R52C/E56C/R59C/E63C-Fr | 分子名称: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | 著者 | Hishikawa, Y, Maity, B, Ito, N, Abe, S, Lu, D, Ueno, T. | 登録日 | 2020-03-19 | 公開日 | 2021-01-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Design of Multinuclear Gold Binding Site at the Two-fold Symmetric Interface of the Ferritin Cage Chem Lett., 49, 2021
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8EDT
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8QBX
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![BU of 8qbx by Molmil](/molmil-images/mine/8qbx) | Chimeric Adenovirus-derived dodecamer | 分子名称: | Penton protein | 著者 | Buzas, D, Borucu, U, Bufton, J, Kapadalakere, S.Y, Toelzer, C. | 登録日 | 2023-08-25 | 公開日 | 2023-12-27 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Engineering the ADDobody protein scaffold for generation of high-avidity ADDomer super-binders. Structure, 32, 2024
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8E3X
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![BU of 8e3x by Molmil](/molmil-images/mine/8e3x) | Cryo-EM structure of the PAC1R-PACAP27-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Piper, S.J, Danev, R, Sexton, P, Wootten, D. | 登録日 | 2022-08-17 | 公開日 | 2022-11-23 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Understanding VPAC receptor family peptide binding and selectivity. Nat Commun, 13, 2022
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8EDS
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8EDR
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8DOF
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![BU of 8dof by Molmil](/molmil-images/mine/8dof) | Pseudomonas aeruginosa MurC with WYH9-2-P - OSA_001044 | 分子名称: | (2R)-2-cyclohexyl-2-[(4-{[5-(propan-2-yl)-1H-pyrazol-3-yl]amino}-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]ethan-1-ol, 1,2-ETHANEDIOL, SULFATE ION, ... | 著者 | Horanyi, P.S, Wang, Y, Todd, M.H, Abendroth, J, Edwards, T, Lorimer, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | 登録日 | 2022-07-13 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Pseudomonas aeruginosa MurC with WYH9-2-P - OSA_001044 To Be Published
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7C1K
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![BU of 7c1k by Molmil](/molmil-images/mine/7c1k) | Crystal structure of the starter condensation domain of rhizomide synthetase RzmA mutant R148A | 分子名称: | Non-ribosomal peptide synthetase modules | 著者 | Zhong, L, Diao, X, Zhang, N, Li, F.W, Zhou, H.B, Chen, H.N, Ren, X, Zhang, Y, Wu, D, Bian, X. | 登録日 | 2020-05-04 | 公開日 | 2020-11-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | 主引用文献 | Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis. Nat Commun, 12, 2021
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8E3Z
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![BU of 8e3z by Molmil](/molmil-images/mine/8e3z) | Cryo-EM structure of the VPAC1R-VIP-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Piper, S.J, Danev, R, Sexton, P, Wootten, D. | 登録日 | 2022-08-17 | 公開日 | 2022-11-23 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Understanding VPAC receptor family peptide binding and selectivity. Nat Commun, 13, 2022
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8E3Y
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![BU of 8e3y by Molmil](/molmil-images/mine/8e3y) | Cryo-EM structure of the VPAC1R-PACAP27-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Piper, S.J, Danev, R, Sexton, P, Wootten, D. | 登録日 | 2022-08-17 | 公開日 | 2022-11-23 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Understanding VPAC receptor family peptide binding and selectivity. Nat Commun, 13, 2022
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7B9O
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![BU of 7b9o by Molmil](/molmil-images/mine/7b9o) | Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with S169 inhibitor | 分子名称: | 3-(5-(3,5-bis(trifluoromethyl)phenyl)-4-phenyloxazol-2-yl)propanoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | 著者 | Ni, X, Chaikuad, A, Schierle, S, Merk, D, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-12-14 | 公開日 | 2021-02-10 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. J.Med.Chem., 64, 2021
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8R2I
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![BU of 8r2i by Molmil](/molmil-images/mine/8r2i) | Cryo-EM Structure of native Photosystem II assembly intermediate from Chlamydomonas reinhardtii | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, 2,3-DIMETHYL-5-(3,7,11,15,19,23,27,31,35-NONAMETHYL-2,6,10,14,18,22,26,30,34-HEXATRIACONTANONAENYL-2,5-CYCLOHEXADIENE-1,4-DIONE-2,3-DIMETHYL-5-SOLANESYL-1,4-BENZOQUINONE, ... | 著者 | Fadeeva, M, Klaiman, D, Kandiah, E, Nelson, N. | 登録日 | 2023-11-06 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure of native photosystem II assembly intermediate from Chlamydomonas reinhardtii . Front Plant Sci, 14, 2023
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7BUP
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8DPR
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![BU of 8dpr by Molmil](/molmil-images/mine/8dpr) | Crystal structure of SARS-CoV-2 main protease in complex with inhibitor TKB-248 | 分子名称: | 2,2,2-trifluoro-N-{(2S)-1-[(1R,2S,5S)-2-({(2S)-1-(4-fluoro-1,3-benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}carbamothioyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-3,3-dimethyl-1-oxobutan-2-yl}acetamide, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, ... | 著者 | Bulut, H, Hayashi, H, Tsuji, K, Kuwata, N, Das, D, Tamamura, H, Mitsuya, H. | 登録日 | 2022-07-16 | 公開日 | 2022-08-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of SARS-CoV-2 M pro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nat Commun, 14, 2023
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8DOY
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![BU of 8doy by Molmil](/molmil-images/mine/8doy) | Crystal structure of SARS-CoV-2 main protease in complex with an inhibitor TKB-198 | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3C-like proteinase nsp5, ... | 著者 | Bulut, H, Hayashi, H, Tsuji, K, Kuwata, N, Das, D, Tamamura, H, Mitsuya, H. | 登録日 | 2022-07-14 | 公開日 | 2022-08-24 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Potent and biostable inhibitors of the main protease of SARS-CoV-2. Iscience, 25, 2022
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8DTL
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![BU of 8dtl by Molmil](/molmil-images/mine/8dtl) | Cryo-EM structure of insulin receptor (IR) bound with S597 peptide | 分子名称: | Insulin mimetic peptide S597, Insulin receptor | 著者 | Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. | 登録日 | 2022-07-25 | 公開日 | 2022-09-07 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
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8DTM
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![BU of 8dtm by Molmil](/molmil-images/mine/8dtm) | Cryo-EM structure of insulin receptor (IR) bound with S597 component 2 | 分子名称: | Insulin mimetic peptide S597 component 2, Insulin receptor | 著者 | Park, J, Li, J, Mayer, J.P, Ball, K.A, Wu, J.Y, Hall, C, Accili, D, Stowell, M.H.B, Bai, X.C, Choi, E. | 登録日 | 2022-07-26 | 公開日 | 2022-09-07 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Activation of the insulin receptor by an insulin mimetic peptide. Nat Commun, 13, 2022
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7BDZ
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![BU of 7bdz by Molmil](/molmil-images/mine/7bdz) | X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (1) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Lysozyme, ... | 著者 | Loreto, D, Merlino, A, Ferraro, G. | 登録日 | 2020-12-22 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme. Int J Mol Sci, 22, 2021
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7BCM
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![BU of 7bcm by Molmil](/molmil-images/mine/7bcm) | The DDR1 Kinase Domain Bound To SR302 | 分子名称: | Epithelial discoidin domain-containing receptor 1, ~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{S})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide | 著者 | Mathea, S, Chatterjee, D, Preuss, F, Roehm, S, Joerger, A, Knapp, S. | 登録日 | 2020-12-20 | 公開日 | 2021-03-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. J.Med.Chem., 64, 2021
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7BEC
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![BU of 7bec by Molmil](/molmil-images/mine/7bec) | Unusual structural features in the adduct of dirhodium tetraacetate with lysozyme (5) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Lysozyme, ... | 著者 | Loreto, D, Ferraro, G, Merlino, A. | 登録日 | 2020-12-23 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme. Int J Mol Sci, 22, 2021
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7BEB
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![BU of 7beb by Molmil](/molmil-images/mine/7beb) | Unusual structural features in the adduct of dirhodium tetraacetate with lysozyme (4) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Lysozyme, ... | 著者 | Loreto, D, Ferraro, G, Merlino, A. | 登録日 | 2020-12-23 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme. Int J Mol Sci, 22, 2021
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7BE2
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![BU of 7be2 by Molmil](/molmil-images/mine/7be2) | X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (6) | 分子名称: | ACETATE ION, GLYCEROL, Lysozyme, ... | 著者 | Loreto, D, Merlino, A, Ferraro, G. | 登録日 | 2020-12-22 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme. Int J Mol Sci, 22, 2021
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