8E3Z
Cryo-EM structure of the VPAC1R-VIP-Gs complex
Summary for 8E3Z
Entry DOI | 10.2210/pdb8e3z/pdb |
EMDB information | 27874 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | membrane protein, drug discovery, g protein coupled receptor, signalling |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 163188.90 |
Authors | Piper, S.J.,Danev, R.,Sexton, P.,Wootten, D. (deposition date: 2022-08-17, release date: 2022-11-23, Last modification date: 2024-05-01) |
Primary citation | Piper, S.J.,Deganutti, G.,Lu, J.,Zhao, P.,Liang, Y.L.,Lu, Y.,Fletcher, M.M.,Hossain, M.A.,Christopoulos, A.,Reynolds, C.A.,Danev, R.,Sexton, P.M.,Wootten, D. Understanding VPAC receptor family peptide binding and selectivity. Nat Commun, 13:7013-7013, 2022 Cited by PubMed: 36385145DOI: 10.1038/s41467-022-34629-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.7 Å) |
Structure validation
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